ATE384129T1 - Künstliche antikörperbibliothek mit super- repertoire - Google Patents
Künstliche antikörperbibliothek mit super- repertoireInfo
- Publication number
- ATE384129T1 ATE384129T1 AT02803566T AT02803566T ATE384129T1 AT E384129 T1 ATE384129 T1 AT E384129T1 AT 02803566 T AT02803566 T AT 02803566T AT 02803566 T AT02803566 T AT 02803566T AT E384129 T1 ATE384129 T1 AT E384129T1
- Authority
- AT
- Austria
- Prior art keywords
- library
- region
- repertoire
- super
- artificial antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Applications Or Details Of Rotary Compressors (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001358602 | 2001-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE384129T1 true ATE384129T1 (de) | 2008-02-15 |
Family
ID=19169753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02803566T ATE384129T1 (de) | 2001-11-22 | 2002-11-22 | Künstliche antikörperbibliothek mit super- repertoire |
Country Status (7)
Country | Link |
---|---|
US (1) | US8178320B2 (de) |
EP (1) | EP1457559B1 (de) |
JP (1) | JP4171844B2 (de) |
AT (1) | ATE384129T1 (de) |
AU (1) | AU2002366039A1 (de) |
DE (1) | DE60224720D1 (de) |
WO (1) | WO2003044198A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005021719A2 (en) | 2003-08-27 | 2005-03-10 | Proterec Ltd | Libraries of recombinant chimeric proteins |
JP4524414B2 (ja) * | 2004-08-24 | 2010-08-18 | 学校法人東海大学 | 糖結合性ファージ提示型抗体の解析方法 |
JP2006055141A (ja) * | 2004-08-24 | 2006-03-02 | Tokai Univ | 糖鎖構造に特異的な抗体の同定方法 |
JP2007306828A (ja) * | 2006-05-17 | 2007-11-29 | Tokai Univ | 非還元マンノース残基を認識するファージ提示型単鎖抗体 |
JP5239766B2 (ja) | 2008-11-14 | 2013-07-17 | 富士通セミコンダクター株式会社 | レイアウト設計方法 |
EP2578682B1 (de) * | 2010-06-04 | 2016-07-27 | Toagosei Co., Ltd. | Antikörper und verwendung davon |
US10309969B2 (en) | 2013-01-24 | 2019-06-04 | Abtlas Co., Ltd. | Protein combination-based FV library, and preparation method therefor |
WO2016114567A1 (ko) * | 2015-01-13 | 2016-07-21 | 이화여자대학교 산학협력단 | 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리 |
JP6867302B2 (ja) * | 2015-05-21 | 2021-04-28 | フル スペクトラム ジェネティクス, インコーポレイテッド | タンパク質の特徴を改善する方法 |
WO2019036856A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | DYNAMIC BANKS OF LIGHT CHAIN OF HUMAN ANTIBODY |
CN111279024A (zh) * | 2017-08-21 | 2020-06-12 | 天演药业公司 | 动态人重链抗体文库 |
CN112557644B (zh) * | 2020-12-21 | 2024-03-22 | 珠海碳云智能科技有限公司 | 用于对目标抗体进行检测的多肽的筛选方法及其筛选的多肽的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
AU695406B2 (en) | 1994-03-30 | 1998-08-13 | Igen International, Inc. | The isolation and production of catalytic antibodies using phage technology |
ATE222289T1 (de) | 1995-06-07 | 2002-08-15 | Invitrogen Corp | Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte |
EP0996718B1 (de) | 1997-03-18 | 2008-12-24 | Novozymes A/S | Methode zur herstellung einer bibliothek mittels dna-shuffling |
JP4206154B2 (ja) | 1997-11-13 | 2009-01-07 | 大日本住友製薬株式会社 | 変異型loxP配列とその応用 |
WO1999031270A1 (fr) | 1997-12-15 | 1999-06-24 | Fujisawa Pharmaceutical Co., Ltd. | Tri par hybridation numerique |
IT1303776B1 (it) * | 1998-11-19 | 2001-02-23 | S I S S A Scuola Internaz Supe | Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti. |
US6410317B1 (en) | 1999-07-14 | 2002-06-25 | Clontech Laboratories, Inc. | Recombinase-based methods for producing expression vectors and compositions for use in practicing the same |
EP1092768A1 (de) * | 1999-10-16 | 2001-04-18 | ARTEMIS Pharmaceuticals GmbH | Konstrukt zum bedingten einfangen und Disruption von Genen |
GB0008419D0 (en) * | 2000-04-05 | 2000-05-24 | Bioinvent Int Ab | A method for invitro molecular evolution of antibody function |
US6912504B1 (en) * | 2000-04-28 | 2005-06-28 | Blackarrow, Inc. | Distributing television advertisements over the internet |
AU2001271912A1 (en) * | 2000-07-07 | 2002-01-21 | Maxygen, Inc. | Molecular breeding of transposable elements |
AU2002219841A1 (en) | 2000-11-16 | 2002-05-27 | Cornell Research Foundation Inc. | Vectors for conditional gene inactivation |
-
2002
- 2002-11-22 AU AU2002366039A patent/AU2002366039A1/en not_active Abandoned
- 2002-11-22 US US10/496,349 patent/US8178320B2/en not_active Expired - Lifetime
- 2002-11-22 DE DE60224720T patent/DE60224720D1/de not_active Expired - Lifetime
- 2002-11-22 JP JP2003545819A patent/JP4171844B2/ja not_active Expired - Fee Related
- 2002-11-22 AT AT02803566T patent/ATE384129T1/de not_active IP Right Cessation
- 2002-11-22 EP EP02803566A patent/EP1457559B1/de not_active Expired - Lifetime
- 2002-11-22 WO PCT/JP2002/012236 patent/WO2003044198A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US8178320B2 (en) | 2012-05-15 |
JPWO2003044198A1 (ja) | 2005-03-24 |
JP4171844B2 (ja) | 2008-10-29 |
AU2002366039A1 (en) | 2003-06-10 |
EP1457559B1 (de) | 2008-01-16 |
WO2003044198A1 (fr) | 2003-05-30 |
US20060057632A1 (en) | 2006-03-16 |
DE60224720D1 (en) | 2008-03-06 |
EP1457559A1 (de) | 2004-09-15 |
EP1457559A4 (de) | 2005-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |