ATE381963T1 - METHOD FOR PRODUCING PURIFIED PARTICLES - Google Patents
METHOD FOR PRODUCING PURIFIED PARTICLESInfo
- Publication number
- ATE381963T1 ATE381963T1 AT01204096T AT01204096T ATE381963T1 AT E381963 T1 ATE381963 T1 AT E381963T1 AT 01204096 T AT01204096 T AT 01204096T AT 01204096 T AT01204096 T AT 01204096T AT E381963 T1 ATE381963 T1 AT E381963T1
- Authority
- AT
- Austria
- Prior art keywords
- microparticles
- producing purified
- purified particles
- carry
- purifying
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000011859 microparticle Substances 0.000 abstract 3
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009295 crossflow filtration Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/08—Specific process operations in the concentrate stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00004—Scale aspects
- B01J2219/00006—Large-scale industrial plants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/0004—Processes in series
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention is directed to a method for purifying microparticles. These microparticles are prepared in a liquid medium and are recovered free from impurities and undesirable reaction products by tangential flow filtration. In addition, an apparatus has been claimed to carry out the method of the invention. Since the microparticles are essentially intended to carry drugs or other biologically active compounds, the entire process can be carried out aseptically. <IMAGE>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01204096A EP1306127B2 (en) | 2001-10-26 | 2001-10-26 | Method for the preparation of purified microparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE381963T1 true ATE381963T1 (en) | 2008-01-15 |
Family
ID=8181147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01204096T ATE381963T1 (en) | 2001-10-26 | 2001-10-26 | METHOD FOR PRODUCING PURIFIED PARTICLES |
Country Status (6)
Country | Link |
---|---|
US (1) | US7468151B2 (en) |
EP (2) | EP1306127B2 (en) |
AT (1) | ATE381963T1 (en) |
CA (1) | CA2464668C (en) |
DE (1) | DE60132094T3 (en) |
WO (1) | WO2003035244A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
DE10205362A1 (en) * | 2002-02-08 | 2003-08-21 | Abbott Gmbh & Co Kg | Process for the preparation of water-dispersible dry powder of water-poorly soluble compounds |
EP1595534A1 (en) | 2004-05-13 | 2005-11-16 | Universiteit Utrecht Holding B.V. | Gel composition comprising charged polymers |
US8846102B2 (en) | 2006-03-30 | 2014-09-30 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
CA2656411A1 (en) * | 2006-06-28 | 2008-01-03 | Surmodics, Inc. | Combination degradable and non-degradable matrices for active agent delivery |
ATE475686T1 (en) * | 2006-10-31 | 2010-08-15 | Surmodics Pharmaceuticals Inc | SPHERICAL POLYMER PARTICLES |
PT2195035T (en) | 2007-09-28 | 2018-03-07 | Engene Inc | High concentration chitosan-nucleic acid polyplex compositions |
US7988859B2 (en) * | 2009-02-05 | 2011-08-02 | Chromatan Inc. | Countercurrent tangential chromatography methods, systems, and apparatus |
WO2010102065A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
CN102458117B (en) * | 2009-05-01 | 2015-11-25 | 阿普塔利斯医药科技公司 | The Orally disintegrating tablet compositions of the combination containing non-opium sample and opium sample analgesic |
SG178195A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Long acting insulin composition |
WO2011012718A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Prodrugs comprising an insulin linker conjugate |
JP5893566B2 (en) | 2009-10-29 | 2016-03-23 | アセンディス ファーマ エー/エス | Sterilization of biodegradable hydrogels |
CA2787656A1 (en) * | 2010-01-22 | 2011-07-28 | Lonza Walkersville, Inc. | High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration |
WO2011100458A2 (en) * | 2010-02-10 | 2011-08-18 | Bioo Scientific Corporation | Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery |
EP2555752B1 (en) | 2010-04-09 | 2019-06-26 | Pacira Pharmaceuticals, Inc. | Method for formulating multivesicular liposomes |
US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
US9084727B2 (en) | 2011-05-10 | 2015-07-21 | Bend Research, Inc. | Methods and compositions for maintaining active agents in intra-articular spaces |
DK2773326T3 (en) * | 2011-11-04 | 2019-04-15 | Nitto Denko Corp | PROCEDURE FOR STERILE PREPARATION OF LIPID NUCLEIC ACID PARTICLES |
EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
EP2730333A1 (en) | 2012-11-08 | 2014-05-14 | Sanofi-Aventis Deutschland GmbH | Mixing system for processing sensitive substances |
KR102274714B1 (en) | 2013-03-13 | 2021-07-09 | 씨젠 인크. | Cyclodextrin and antibody-drug conjugate formulations |
MX2016014863A (en) | 2014-05-27 | 2017-06-21 | Artificial Cell Tech Inc | Automated layer by layer construction of multilayer coated cores by tff. |
US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
PT108368B (en) * | 2015-03-31 | 2018-11-05 | Hovione Farm S A | Continuous production of particles |
EP3589666B1 (en) * | 2017-02-28 | 2021-01-13 | Total Research & Technology Feluy | Process for producing monovinylaromatic polymer incorporating post-consumer recycled polystyrene and installation to produce a monovinylaromatic polymer comprising post-consumer recycled polystyrene |
JP7432511B2 (en) | 2018-03-08 | 2024-02-16 | レプリゲン・コーポレイション | Tangential flow depth filtration system and filtration method using the same |
EP3801844A4 (en) | 2018-05-25 | 2022-07-13 | Repligen Corporation | Tangential flow filtration systems and methods |
CN110038350A (en) * | 2019-04-18 | 2019-07-23 | 苏州星烁纳米科技有限公司 | The device and purification process of purified nanotubes crystalline substance solution |
CN112870533B (en) * | 2020-12-21 | 2022-06-14 | 科塞尔医疗科技(苏州)有限公司 | Medicine carrying microsphere preparation device |
WO2023099536A1 (en) * | 2021-12-02 | 2023-06-08 | Microcaps Ag | Capsule gelation quenching unit |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS56133302A (en) * | 1980-03-25 | 1981-10-19 | Nippon Zeon Co Ltd | Production of high-purity polymer by emulsion polymerization |
JPS60100516A (en) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | Preparation of sustained release microcapsule |
US5264988A (en) * | 1986-07-19 | 1993-11-23 | Ken Hayashibara | Circuit to limit surges into a dc-operated lamp |
US5069936A (en) | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
FR2651680B1 (en) | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | NOVEL PROCESS FOR THE PREPARATION OF LIPID MICROPARTICLES. |
PT752245E (en) * | 1995-07-05 | 2002-09-30 | Europ Economic Community | BIOCOMPATIBLE AND BIODEGRADABLE NANOPARTICLES FOR THE ABSORPTION AND ADMINISTRATION OF PROTEINACEAL DRUGS |
DE19545257A1 (en) * | 1995-11-24 | 1997-06-19 | Schering Ag | Process for the production of morphologically uniform microcapsules and microcapsules produced by this process |
DE19611769A1 (en) | 1996-03-14 | 1997-09-18 | Schering Ag | Microparticles, processes for their production and their use in ultrasound diagnostics |
ES2198579T3 (en) | 1996-07-01 | 2004-02-01 | Universiteit Utrecht | HYDROGELS HYDROLIZABLE FOR CONTROLLED RELEASE. |
EP0842657A1 (en) * | 1996-11-19 | 1998-05-20 | OctoPlus B.V. | Microspheres for controlled release and processes to prepare these microspheres |
ATE322890T1 (en) | 1996-11-19 | 2006-04-15 | Octoplus B V | METHOD FOR PRODUCING A CONTROLLED RELEASE SYSTEM |
US5945126A (en) † | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
US5947689A (en) | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
JP2002503254A (en) | 1997-06-05 | 2002-01-29 | ヘモスフィア,インコーポレイテッド | Microspheres coated with fibrinogen |
IL135989A0 (en) † | 1997-11-14 | 2001-05-20 | Skyepharma Inc | Processes for the production of multivesicular liposomes |
US6270802B1 (en) † | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
FR2806005B1 (en) * | 2000-03-10 | 2002-06-14 | Univ Claude Bernard Lyon | PROCESS FOR THE PREPARATION OF COLLOIDAL PARTICLES IN THE FORM OF NANOCAPSULES |
-
2001
- 2001-10-26 AT AT01204096T patent/ATE381963T1/en active
- 2001-10-26 EP EP01204096A patent/EP1306127B2/en not_active Expired - Lifetime
- 2001-10-26 DE DE60132094T patent/DE60132094T3/en not_active Expired - Lifetime
-
2002
- 2002-10-23 WO PCT/NL2002/000672 patent/WO2003035244A1/en not_active Application Discontinuation
- 2002-10-23 US US10/493,906 patent/US7468151B2/en active Active
- 2002-10-23 CA CA2464668A patent/CA2464668C/en not_active Expired - Lifetime
- 2002-10-23 EP EP02770308A patent/EP1444033A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1306127B2 (en) | 2011-09-07 |
DE60132094T2 (en) | 2008-12-11 |
WO2003035244A1 (en) | 2003-05-01 |
DE60132094D1 (en) | 2008-02-07 |
CA2464668A1 (en) | 2003-05-01 |
EP1306127B1 (en) | 2007-12-26 |
US20050084536A1 (en) | 2005-04-21 |
EP1444033A1 (en) | 2004-08-11 |
EP1306127A1 (en) | 2003-05-02 |
DE60132094T3 (en) | 2012-02-02 |
CA2464668C (en) | 2011-06-14 |
US7468151B2 (en) | 2008-12-23 |
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