ATE379990T1 - Verfahren zur darstellung von abgestorbenen zellen in-vivo - Google Patents
Verfahren zur darstellung von abgestorbenen zellen in-vivoInfo
- Publication number
- ATE379990T1 ATE379990T1 AT98920065T AT98920065T ATE379990T1 AT E379990 T1 ATE379990 T1 AT E379990T1 AT 98920065 T AT98920065 T AT 98920065T AT 98920065 T AT98920065 T AT 98920065T AT E379990 T1 ATE379990 T1 AT E379990T1
- Authority
- AT
- Austria
- Prior art keywords
- vivo
- dead cells
- displaying
- displaying dead
- cells
- Prior art date
Links
- 238000001727 in vivo Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000000412 Annexin Human genes 0.000 abstract 1
- 108050008874 Annexin Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4057—Arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/425—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hydroponics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4539997P | 1997-04-30 | 1997-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE379990T1 true ATE379990T1 (de) | 2007-12-15 |
Family
ID=21937648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98920065T ATE379990T1 (de) | 1997-04-30 | 1998-04-28 | Verfahren zur darstellung von abgestorbenen zellen in-vivo |
Country Status (16)
Country | Link |
---|---|
US (3) | US6197278B1 (de) |
EP (1) | EP1017318B1 (de) |
JP (1) | JP4963748B2 (de) |
KR (1) | KR20010020443A (de) |
CN (1) | CN1265572A (de) |
AT (1) | ATE379990T1 (de) |
AU (1) | AU754577B2 (de) |
CA (1) | CA2288131A1 (de) |
DE (1) | DE69838811T2 (de) |
ES (1) | ES2398118T3 (de) |
HU (1) | HUP0001261A3 (de) |
NZ (1) | NZ500598A (de) |
PL (1) | PL336571A1 (de) |
RU (1) | RU2228765C2 (de) |
TW (1) | TW541184B (de) |
WO (1) | WO1998048699A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0001261A3 (en) * | 1997-04-30 | 2001-11-28 | Univ Washington Seattle | Method of imaging cell death in vivo |
US7736651B1 (en) * | 2000-11-24 | 2010-06-15 | Sloan-Kettering Institute For Cancer Research | Alpha emitting constructs and uses thereof |
US6818213B1 (en) * | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
AU771224B2 (en) | 1998-07-13 | 2004-03-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
IL140700A0 (en) * | 1998-07-13 | 2002-02-10 | Univ Texas | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US6692724B1 (en) | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
DK1286704T3 (da) * | 2000-06-02 | 2014-09-22 | Univ Texas | Ethylendicystein (EC)-glucose analoge konjugater |
AU2001272967A1 (en) * | 2000-06-22 | 2002-01-02 | Henry Ford Health System | Imaging and targeting tumors using sickle cells |
US20050013778A1 (en) * | 2001-04-03 | 2005-01-20 | Theseus Imaging Corporation | Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death |
WO2002082044A2 (en) * | 2001-04-03 | 2002-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
WO2002080754A2 (en) * | 2001-04-03 | 2002-10-17 | Theseus Imaging Corporation | Methods for using annexin for detecting cell death in vivo and treating associated conditions |
EP1610751A4 (de) * | 2001-04-26 | 2006-05-24 | Univ Texas | Therapeutisches mittel/ligand-konjugat-zusammensetzungen, ihre syntheseverfahren und ihre anwendung |
US20030202937A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Minicell-based diagnostics |
US20030152513A1 (en) * | 2001-09-06 | 2003-08-14 | Imetrix, Inc. | Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector |
US7261875B2 (en) | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
US20040042959A1 (en) * | 2002-08-28 | 2004-03-04 | Michael Montalto | Imaging cell death in vivo using non-radionuclide contrast agents |
JP2006515835A (ja) * | 2002-11-07 | 2006-06-08 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 組織特異的疾患のイメージングのための、エチレンジシステイン(ec)−薬物結合体、組成物、および方法 |
US20070031333A1 (en) * | 2003-01-02 | 2007-02-08 | Mease Ronnie C | Novel F-18 labeled annexin V, synthesis thereof, and use thereof |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
US7511016B2 (en) * | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
US7874975B2 (en) * | 2005-07-20 | 2011-01-25 | Clear Vascular, Inc. | Methods and compositions for treating luminal inflammatory disease |
US9623129B2 (en) * | 2005-09-26 | 2017-04-18 | Snip Holdings, Inc. | Methods and therapies for treating inflammatory conditions with exposed collagen |
US8187573B2 (en) * | 2005-10-21 | 2012-05-29 | Immunochemistry Technologies, Llc | In vivo detection of apoptosis |
US7871623B2 (en) * | 2005-12-21 | 2011-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for imaging pain and stress in vivo |
US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
AU2008211786B2 (en) * | 2007-01-30 | 2014-07-03 | Ge Healthcare Limited | Tools for aiding in the diagnosis of neurodegenerative diseases |
WO2008142590A2 (en) * | 2007-05-16 | 2008-11-27 | Koninklijke Philips Electronics N.V. | Virtual pet detector and quasi-pixelated readout scheme for pet |
US8055039B2 (en) * | 2008-02-21 | 2011-11-08 | General Electric Company | System and method to obtain noise mitigated monochromatic representation for varying energy level |
US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
AU2009231978C1 (en) * | 2008-03-31 | 2014-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as A3 adenosine receptor- selective agonists |
US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
US8796291B2 (en) * | 2008-08-01 | 2014-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists and partial agonists |
AU2009286244B2 (en) | 2008-08-26 | 2014-08-14 | Mosamedix B.V. | Radiolabeled annexins |
US8283167B2 (en) * | 2009-02-11 | 2012-10-09 | Clear Vascular Inc. | Preparation of annexin derivatives |
RU2595504C2 (ru) | 2011-04-04 | 2016-08-27 | Айди Интернешнл Научно-Исследовательская И Опытно-Конструкторская Корпорация | Одноразовый шприц для безыгольного инъектора |
KR20160021789A (ko) * | 2013-05-23 | 2016-02-26 | 뉴로슨, 인크. | 방사성 핵종으로 분류된 아넥신을 사용해서 알츠하이머 질환의 진단 및 치료 |
CN105669855B (zh) * | 2016-02-04 | 2020-02-11 | 江苏省原子医学研究所 | 一种18F快速标记Cys-Annexin V的方法及其应用 |
RU2622983C1 (ru) * | 2016-07-25 | 2017-06-21 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда |
WO2019169241A1 (en) * | 2018-03-02 | 2019-09-06 | Serene, Llc | Methods of treating and imaging ungulate laminitis |
JP2024022034A (ja) * | 2022-08-05 | 2024-02-16 | 浜松ホトニクス株式会社 | プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4665897A (en) * | 1984-05-25 | 1987-05-19 | Lemelson Jerome H | Composition and method for detecting and treating cancer |
US5627036A (en) | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
US5552525A (en) | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
EP0538459A4 (en) | 1991-05-09 | 1993-06-16 | The Board Of Regents Of The University Of Washington | Phospholipid-targeted thrombolytic agents |
US5519221A (en) | 1992-01-22 | 1996-05-21 | Ansel M. Schwartz | Dedicated apparatus and method for emission mammography |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
CA2131528C (en) | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
GB9223168D0 (en) | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
ATE160875T1 (de) | 1994-04-11 | 1997-12-15 | Nexins Research B V | Verfahren zum nachweis und/oder zur bestimmung und/oder zur isolierung von apoptotischen zellen in oder aus einer probe |
EP0765166B1 (de) | 1994-06-16 | 2003-05-21 | Neorx Corporation | Radioaktivmarkierte annexin-galaktose konjugate |
EP0799050B1 (de) | 1994-12-07 | 2004-08-11 | Neorx Corporation | Radioaktivmarkierte annexin-galaktose-cluster konjugate |
HUP0001261A3 (en) * | 1997-04-30 | 2001-11-28 | Univ Washington Seattle | Method of imaging cell death in vivo |
AU771224B2 (en) | 1998-07-13 | 2004-03-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
IL140700A0 (en) | 1998-07-13 | 2002-02-10 | Univ Texas | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
-
1998
- 1998-04-28 HU HU0001261A patent/HUP0001261A3/hu unknown
- 1998-04-28 EP EP98920065A patent/EP1017318B1/de not_active Expired - Lifetime
- 1998-04-28 WO PCT/US1998/008769 patent/WO1998048699A1/en active IP Right Grant
- 1998-04-28 CA CA002288131A patent/CA2288131A1/en not_active Abandoned
- 1998-04-28 JP JP54740298A patent/JP4963748B2/ja not_active Expired - Lifetime
- 1998-04-28 CN CN98804718A patent/CN1265572A/zh active Pending
- 1998-04-28 AT AT98920065T patent/ATE379990T1/de not_active IP Right Cessation
- 1998-04-28 PL PL98336571A patent/PL336571A1/xx unknown
- 1998-04-28 TW TW087106507A patent/TW541184B/zh not_active IP Right Cessation
- 1998-04-28 AU AU72714/98A patent/AU754577B2/en not_active Ceased
- 1998-04-28 RU RU99125653/14A patent/RU2228765C2/ru not_active IP Right Cessation
- 1998-04-28 NZ NZ500598A patent/NZ500598A/en unknown
- 1998-04-28 KR KR1019997010074A patent/KR20010020443A/ko active IP Right Grant
- 1998-04-28 ES ES07023446T patent/ES2398118T3/es not_active Expired - Lifetime
- 1998-04-28 DE DE69838811T patent/DE69838811T2/de not_active Expired - Lifetime
- 1998-04-29 US US09/069,878 patent/US6197278B1/en not_active Expired - Lifetime
-
2002
- 2002-08-02 US US10/210,986 patent/US7357915B2/en not_active Expired - Fee Related
-
2007
- 2007-11-15 US US11/985,567 patent/US7666389B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20070243133A1 (en) | 2007-10-18 |
ES2398118T3 (es) | 2013-03-13 |
DE69838811T2 (de) | 2008-10-30 |
US6197278B1 (en) | 2001-03-06 |
HUP0001261A2 (hu) | 2000-08-28 |
DE69838811D1 (de) | 2008-01-17 |
KR20010020443A (ko) | 2001-03-15 |
PL336571A1 (en) | 2000-07-03 |
AU754577B2 (en) | 2002-11-21 |
EP1017318A1 (de) | 2000-07-12 |
RU2228765C2 (ru) | 2004-05-20 |
JP2002500757A (ja) | 2002-01-08 |
JP4963748B2 (ja) | 2012-06-27 |
US7357915B2 (en) | 2008-04-15 |
WO1998048699A1 (en) | 1998-11-05 |
EP1017318B1 (de) | 2007-12-05 |
CA2288131A1 (en) | 1998-11-05 |
HUP0001261A3 (en) | 2001-11-28 |
EP1017318A4 (de) | 2003-04-23 |
US20080138279A1 (en) | 2008-06-12 |
TW541184B (en) | 2003-07-11 |
AU7271498A (en) | 1998-11-24 |
CN1265572A (zh) | 2000-09-06 |
NZ500598A (en) | 2001-09-28 |
US7666389B2 (en) | 2010-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |