ATE378336T1 - Imidazopyridine als hemmstoffe cyclin abhängiger kinasen - Google Patents
Imidazopyridine als hemmstoffe cyclin abhängiger kinasenInfo
- Publication number
- ATE378336T1 ATE378336T1 AT03786514T AT03786514T ATE378336T1 AT E378336 T1 ATE378336 T1 AT E378336T1 AT 03786514 T AT03786514 T AT 03786514T AT 03786514 T AT03786514 T AT 03786514T AT E378336 T1 ATE378336 T1 AT E378336T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazopyridines
- inhibitors
- cyclin dependent
- dependent kinases
- kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41206302P | 2002-09-19 | 2002-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE378336T1 true ATE378336T1 (de) | 2007-11-15 |
Family
ID=32030794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03786514T ATE378336T1 (de) | 2002-09-19 | 2003-09-17 | Imidazopyridine als hemmstoffe cyclin abhängiger kinasen |
Country Status (19)
Country | Link |
---|---|
US (2) | US6992080B2 (de) |
EP (1) | EP1539756B1 (de) |
JP (1) | JP4845379B2 (de) |
KR (1) | KR20050052500A (de) |
CN (1) | CN100549011C (de) |
AR (1) | AR041291A1 (de) |
AT (1) | ATE378336T1 (de) |
AU (1) | AU2003295332B2 (de) |
CA (1) | CA2499639C (de) |
DE (1) | DE60317529T2 (de) |
ES (1) | ES2293068T3 (de) |
HK (1) | HK1071757A1 (de) |
IL (1) | IL167433A (de) |
MX (1) | MXPA05003058A (de) |
MY (1) | MY133311A (de) |
NZ (1) | NZ538566A (de) |
TW (1) | TWI351405B (de) |
WO (1) | WO2004026867A2 (de) |
ZA (1) | ZA200502278B (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU756699B2 (en) * | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
GB9819530D0 (en) | 1998-09-09 | 1998-10-28 | Smithkline Beecham Plc | Novel compositions and use |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
AU2003260002B2 (en) | 2002-08-23 | 2010-03-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
JP4681548B2 (ja) | 2003-07-22 | 2011-05-11 | アステックス・セラピューティクス・リミテッド | 3,4−ジ置換1h−ピラゾール化合物および、そのサイクリン依存性キナーゼ(cdk)およびグリコーゲン・シンセターゼ・キナーゼ−3(gsk−3)調節剤としての使用 |
GB0418328D0 (en) * | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
CA2593475A1 (en) * | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors and further antitumor agents |
BRPI0606455A (pt) * | 2005-01-21 | 2008-03-11 | Astex Therapeutics Ltd | compostos farmacêuticos |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US20080161251A1 (en) * | 2005-01-21 | 2008-07-03 | Astex Therapeutics Limited | Pharmaceutical Compounds |
EP1861095A1 (de) * | 2005-03-24 | 2007-12-05 | Glaxo Group Limited | Derivate von imidazo(1,2-a)pyridin als nützliche medikamente zur behandlung von magen-darm-erkrankungen |
DE602006016455D1 (de) * | 2005-09-09 | 2010-10-07 | Schering Corp | Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase |
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
WO2007097937A1 (en) | 2006-02-16 | 2007-08-30 | Schering Corporation | Pyrrolidine derivatives as erk inhibitors |
EP2026805A1 (de) * | 2006-05-08 | 2009-02-25 | Astex Therapeutics Limited | Pharmazeutische kombinationen aus diazolderivaten zur krebsbehandlung |
FR2906250B1 (fr) | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
EP2099798A1 (de) | 2006-12-01 | 2009-09-16 | Galapagos N.V. | Für die behandlung von degenerativen und entzündlichen krankheiten geeignete imidazolopyridinverbindungen |
US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
US8426441B2 (en) | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
ES2462642T3 (es) * | 2007-12-14 | 2014-05-26 | F. Hoffmann-La Roche Ag | Nuevos derivados de imidazo[1,2-a]piridina e imidazo[1,2-b]piridazina |
EP2690101B1 (de) * | 2007-12-19 | 2015-06-24 | Genentech, Inc. | 5-Anilin-Imidazopyridine und Verfahren zu ihrer Verwendung |
AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
MY152271A (en) | 2008-02-21 | 2014-09-15 | Merck Sharp & Dohme | Novel compounds that are erk inhibitors |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
EP2300466B1 (de) | 2008-06-20 | 2014-08-06 | Bristol-Myers Squibb Company | Imidazopyridin- und imidazopyrazinverbindungen als kinasehemmer |
CA2726460C (en) | 2008-07-15 | 2017-02-21 | F. Hoffmann-La Roche Ag | Novel phenyl-imidazopyridines and pyridazines |
JPWO2010035745A1 (ja) * | 2008-09-25 | 2012-02-23 | 杏林製薬株式会社 | ヘテロ環ビアリール誘導体及びそれらを有効成分とするpde阻害剤 |
ES2590804T3 (es) | 2008-12-08 | 2016-11-23 | Gilead Connecticut, Inc. | Inhibidores de Imidazopyrazine Syk |
BRPI0922226A2 (pt) | 2008-12-08 | 2015-12-29 | Gilead Connecticut Inc | inibidores de syk imidazopirazina. |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
AU2010311511B2 (en) | 2009-10-30 | 2014-07-17 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
PT2545052E (pt) | 2010-03-11 | 2015-02-18 | Gilead Connecticut Inc | Inibidores da syk à base de imidazopiridinas |
JP5951750B2 (ja) * | 2011-04-06 | 2016-07-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換イミダゾピリジン類およびその中間体 |
ES2575092T3 (es) | 2011-06-27 | 2016-06-24 | Janssen Pharmaceutica, N.V. | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina |
UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
US9669035B2 (en) | 2012-06-26 | 2017-06-06 | Janssen Pharmaceutica Nv | Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders |
EP2869822B1 (de) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Hemmer des phosphodiesterase-10-enzyms |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
MX2016001480A (es) | 2013-07-30 | 2017-01-05 | Gilead Connecticut Inc | Formulacion de inhibidores de syk. |
EP3027618B1 (de) | 2013-07-30 | 2020-07-08 | Gilead Connecticut, Inc. | Polymorph von syk-hemmern |
CN105764516A (zh) | 2013-12-04 | 2016-07-13 | 吉利德科学公司 | 治疗癌症的方法 |
TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
EP3169366A1 (de) | 2014-07-14 | 2017-05-24 | Gilead Sciences, Inc. | Kombinationen zur behandlung von krebs |
JP6895963B2 (ja) | 2015-11-18 | 2021-06-30 | ジェンザイム・コーポレーション | 多発性嚢胞腎のバイオマーカーおよびその使用 |
CA3011442A1 (en) | 2016-01-14 | 2017-07-20 | Handok Inc. | Compounds antagonizing a3 adenosine receptor, method for preparing them, and medical-use thereof |
WO2018139436A1 (ja) | 2017-01-24 | 2018-08-02 | 住友化学株式会社 | 縮合複素環化合物及びそれを含有する組成物 |
US10457683B2 (en) * | 2017-04-12 | 2019-10-29 | Magenta Therapeutics Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
EP3612030A4 (de) * | 2017-04-21 | 2021-04-28 | Ikena Oncology, Inc. | Indol-ahr-inhibitor und verwendungen davon |
US11384082B2 (en) | 2017-08-25 | 2022-07-12 | Kronos Bio, Inc. | Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors |
AU2020225455A1 (en) | 2019-02-22 | 2021-09-09 | Kronos Bio, Inc. | Solid forms of condensed pyrazines as Syk inhibitors |
CN115279764A (zh) | 2019-11-26 | 2022-11-01 | 医肯纳肿瘤学公司 | 多晶型咔唑衍生物及其用途 |
WO2024068740A1 (en) * | 2022-09-28 | 2024-04-04 | Origenis Gmbh | Novel cdk9 inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
CN1079097C (zh) * | 1993-09-10 | 2002-02-13 | 卫材株式会社 | 杂二环磺胺衍生物和磺酸酯衍生物 |
WO1996034866A1 (en) | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
JP4007743B2 (ja) * | 1999-02-26 | 2007-11-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害剤 |
ES2341843T3 (es) * | 2000-02-03 | 2010-06-29 | EISAI R&D MANAGEMENT CO., LTD. | Inhibidores de la expresion de integrina. |
SE0003186D0 (sv) | 2000-09-07 | 2000-09-07 | Astrazeneca Ab | New process |
KR100904599B1 (ko) * | 2001-03-08 | 2009-06-25 | 아스트라제네카 아베 | 신규 용도 |
-
2003
- 2003-09-17 MY MYPI20033536A patent/MY133311A/en unknown
- 2003-09-17 MX MXPA05003058A patent/MXPA05003058A/es active IP Right Grant
- 2003-09-17 ES ES03786514T patent/ES2293068T3/es not_active Expired - Lifetime
- 2003-09-17 AT AT03786514T patent/ATE378336T1/de not_active IP Right Cessation
- 2003-09-17 CA CA2499639A patent/CA2499639C/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125636A patent/TWI351405B/zh not_active IP Right Cessation
- 2003-09-17 KR KR1020057004361A patent/KR20050052500A/ko active IP Right Grant
- 2003-09-17 JP JP2004538237A patent/JP4845379B2/ja not_active Expired - Fee Related
- 2003-09-17 CN CNB038250470A patent/CN100549011C/zh not_active Expired - Fee Related
- 2003-09-17 EP EP03786514A patent/EP1539756B1/de not_active Expired - Lifetime
- 2003-09-17 US US10/664,338 patent/US6992080B2/en not_active Expired - Lifetime
- 2003-09-17 NZ NZ538566A patent/NZ538566A/en not_active IP Right Cessation
- 2003-09-17 DE DE60317529T patent/DE60317529T2/de not_active Expired - Lifetime
- 2003-09-17 AR ARP030103373A patent/AR041291A1/es not_active Application Discontinuation
- 2003-09-17 WO PCT/US2003/029498 patent/WO2004026867A2/en active IP Right Grant
- 2003-09-17 AU AU2003295332A patent/AU2003295332B2/en not_active Ceased
-
2005
- 2005-03-15 IL IL167433A patent/IL167433A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502278A patent/ZA200502278B/en unknown
- 2005-06-15 HK HK05104993A patent/HK1071757A1/xx not_active IP Right Cessation
- 2005-09-29 US US11/238,597 patent/US7452902B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2293068T3 (es) | 2008-03-16 |
EP1539756B1 (de) | 2007-11-14 |
MY133311A (en) | 2007-11-30 |
JP2006507254A (ja) | 2006-03-02 |
DE60317529D1 (de) | 2007-12-27 |
CA2499639C (en) | 2011-11-08 |
CA2499639A1 (en) | 2004-04-01 |
JP4845379B2 (ja) | 2011-12-28 |
AU2003295332A1 (en) | 2004-04-08 |
NZ538566A (en) | 2008-02-29 |
US7452902B2 (en) | 2008-11-18 |
US20040097517A1 (en) | 2004-05-20 |
TWI351405B (en) | 2011-11-01 |
AR041291A1 (es) | 2005-05-11 |
AU2003295332B2 (en) | 2007-01-18 |
CN100549011C (zh) | 2009-10-14 |
DE60317529T2 (de) | 2008-09-25 |
WO2004026867A2 (en) | 2004-04-01 |
US6992080B2 (en) | 2006-01-31 |
MXPA05003058A (es) | 2005-05-27 |
IL167433A (en) | 2011-03-31 |
CN1703414A (zh) | 2005-11-30 |
KR20050052500A (ko) | 2005-06-02 |
HK1071757A1 (en) | 2005-07-29 |
TW200407322A (en) | 2004-05-16 |
ZA200502278B (en) | 2006-05-31 |
US20060030555A1 (en) | 2006-02-09 |
EP1539756A2 (de) | 2005-06-15 |
WO2004026867A3 (en) | 2004-08-05 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |