ATE376550T1 - Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone - Google Patents

Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone

Info

Publication number
ATE376550T1
ATE376550T1 AT03783210T AT03783210T ATE376550T1 AT E376550 T1 ATE376550 T1 AT E376550T1 AT 03783210 T AT03783210 T AT 03783210T AT 03783210 T AT03783210 T AT 03783210T AT E376550 T1 ATE376550 T1 AT E376550T1
Authority
AT
Austria
Prior art keywords
hydrocodones
hydromorphones
producing
catalytic process
analogs
Prior art date
Application number
AT03783210T
Other languages
English (en)
Inventor
Peter Wang
Carl White
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE376550T1 publication Critical patent/ATE376550T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT03783210T 2002-11-11 2003-11-05 Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone ATE376550T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42536002P 2002-11-11 2002-11-11

Publications (1)

Publication Number Publication Date
ATE376550T1 true ATE376550T1 (de) 2007-11-15

Family

ID=34699796

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03783210T ATE376550T1 (de) 2002-11-11 2003-11-05 Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone

Country Status (9)

Country Link
EP (1) EP1562952B1 (de)
JP (1) JP2007528837A (de)
CN (1) CN100400539C (de)
AT (1) ATE376550T1 (de)
AU (1) AU2003290629B8 (de)
CA (1) CA2545052C (de)
DE (1) DE60317092T2 (de)
ES (1) ES2293058T3 (de)
WO (1) WO2005047291A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399858B2 (en) 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
AU2004319925B2 (en) * 2002-11-11 2010-12-09 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
JP2008538746A (ja) 2005-03-28 2008-11-06 マリンクロッド・インコーポレイテッド ヒドロコドン、ヒドロモルホンおよびその誘導体の触媒的製造方法
ATE493417T1 (de) * 2005-06-16 2011-01-15 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US9040705B2 (en) 2009-04-09 2015-05-26 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds
WO2010118273A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Ruthenium catalysts for the production of hydrocodone, hydromorphone or a derivative thereof
US8383815B2 (en) * 2009-09-21 2013-02-26 Mallinckrodt Llc Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
US8563725B2 (en) 2010-04-29 2013-10-22 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds having low metal content
ES2613403T3 (es) 2011-05-06 2017-05-24 Brock University Proceso de preparación de análogos de la morfina mediante N-desmetilación/funcionalización catalizada por metal y transferencia de grupo intramolecular
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢***酮酸式盐的精制工艺
US20240043447A1 (en) 2020-11-13 2024-02-08 Ferrer Internacional, S.A. Synthesis of hydromorphone base

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics
JP4157669B2 (ja) * 2000-06-13 2008-10-01 独立行政法人科学技術振興機構 縮合複素環の合成方法及び縮合複素環

Also Published As

Publication number Publication date
WO2005047291A9 (en) 2006-06-22
CA2545052C (en) 2011-01-11
EP1562952B1 (de) 2007-10-24
ES2293058T3 (es) 2008-03-16
EP1562952A1 (de) 2005-08-17
DE60317092D1 (de) 2007-12-06
CN1860122A (zh) 2006-11-08
AU2003290629B8 (en) 2008-11-27
AU2003290629B2 (en) 2008-09-18
DE60317092T2 (de) 2008-07-31
WO2005047291A1 (en) 2005-05-26
CA2545052A1 (en) 2005-05-26
JP2007528837A (ja) 2007-10-18
CN100400539C (zh) 2008-07-09
AU2003290629A1 (en) 2005-06-06

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Legal Events

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