ATE368670T1 - Synthetischer prozess für ein intermediat von ecteinacidin und phthalascidin verbindungen - Google Patents

Synthetischer prozess für ein intermediat von ecteinacidin und phthalascidin verbindungen

Info

Publication number: ATE368670T1
Authority: AT; Austria
Prior art keywords: phthalascidin; ecteinacidin; compounds; synthetic process; synthesis
Prior art date: 2000-02-11

Application number

AT01910540T

Other languages

English (en)

Inventor

Elias Corey

Original Assignee

Harvard College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-11

Filing date

2001-02-09

Publication date

2007-08-15

2001-02-09 Application filed by Harvard College filed Critical Harvard College

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368670T1 publication Critical patent/ATE368670T1/de

Links

238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 abstract 2
XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
229960000977 trabectedin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT01910540T 2000-02-11 2001-02-09 Synthetischer prozess für ein intermediat von ecteinacidin und phthalascidin verbindungen ATE368670T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18179500P	2000-02-11	2000-02-11

Publications (1)

Publication Number	Publication Date
ATE368670T1 true ATE368670T1 (de)	2007-08-15

Family

ID=22665840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01910540T ATE368670T1 (de)	2000-02-11	2001-02-09	Synthetischer prozess für ein intermediat von ecteinacidin und phthalascidin verbindungen

Country Status (22)

Country	Link
EP (1)	EP1255759B1 (de)
JP (1)	JP5102925B2 (de)
KR (1)	KR100768331B1 (de)
CN (1)	CN1230437C (de)
AT (1)	ATE368670T1 (de)
AU (2)	AU3813501A (de)
BR (1)	BRPI0108279B1 (de)
CA (1)	CA2400614C (de)
CY (1)	CY1107769T1 (de)
CZ (1)	CZ300326B6 (de)
DE (1)	DE60129669T2 (de)
DK (1)	DK1255759T3 (de)
ES (1)	ES2290114T3 (de)
HU (1)	HU229511B1 (de)
IL (2)	IL151168A0 (de)
MX (1)	MXPA02007767A (de)
NO (1)	NO328648B1 (de)
NZ (1)	NZ520635A (de)
PL (1)	PL209762B1 (de)
PT (1)	PT1255759E (de)
RU (1)	RU2267492C2 (de)
WO (1)	WO2001058905A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2800097C (en)	2010-05-25	2019-01-08	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds and intermediates
CN108101934B (zh) *	2016-11-24	2022-02-08	江苏恒瑞医药股份有限公司	用于制备曲贝替定的方法及其中间体
CN110092802B (zh) *	2019-06-21	2022-01-07	爱斯特（成都）生物制药股份有限公司	一种制备曲贝替定中间体的方法
CN112745327B (zh) *	2019-10-30	2023-08-25	南通诺泰生物医药技术有限公司	一种曲贝替定中间体化合物的制备方法
CN114621245A (zh) *	2020-12-11	2022-06-14	江苏恒瑞医药股份有限公司	一种曲贝替定中间体的晶型及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

2001
- 2001-02-09 WO PCT/US2001/004376 patent/WO2001058905A1/en active IP Right Grant
- 2001-02-09 PT PT01910540T patent/PT1255759E/pt unknown
- 2001-02-09 AU AU3813501A patent/AU3813501A/xx active Pending
- 2001-02-09 AU AU2001238135A patent/AU2001238135B2/en not_active Expired
- 2001-02-09 NZ NZ520635A patent/NZ520635A/en not_active IP Right Cessation
- 2001-02-09 CZ CZ20022683A patent/CZ300326B6/cs not_active IP Right Cessation
- 2001-02-09 AT AT01910540T patent/ATE368670T1/de active
- 2001-02-09 KR KR1020027010342A patent/KR100768331B1/ko active IP Right Grant
- 2001-02-09 EP EP01910540A patent/EP1255759B1/de not_active Expired - Lifetime
- 2001-02-09 IL IL15116801A patent/IL151168A0/xx unknown
- 2001-02-09 ES ES01910540T patent/ES2290114T3/es not_active Expired - Lifetime
- 2001-02-09 MX MXPA02007767A patent/MXPA02007767A/es active IP Right Grant
- 2001-02-09 CN CNB018070973A patent/CN1230437C/zh not_active Expired - Lifetime
- 2001-02-09 JP JP2001558054A patent/JP5102925B2/ja not_active Expired - Lifetime
- 2001-02-09 BR BRPI0108279A patent/BRPI0108279B1/pt active IP Right Grant
- 2001-02-09 CA CA2400614A patent/CA2400614C/en not_active Expired - Lifetime
- 2001-02-09 DE DE60129669T patent/DE60129669T2/de not_active Expired - Lifetime
- 2001-02-09 RU RU2002124134/04A patent/RU2267492C2/ru active
- 2001-02-09 DK DK01910540T patent/DK1255759T3/da active
- 2001-02-09 PL PL356392A patent/PL209762B1/pl unknown
- 2001-02-09 HU HU0204221A patent/HU229511B1/hu unknown
2002
- 2002-08-09 NO NO20023769A patent/NO328648B1/no not_active IP Right Cessation
- 2002-08-09 IL IL151168A patent/IL151168A/en active IP Right Grant
2007
- 2007-10-19 CY CY20071101347T patent/CY1107769T1/el unknown

Also Published As

Publication number	Publication date
BRPI0108279B1 (pt)	2016-04-26
PL209762B1 (pl)	2011-10-31
PT1255759E (pt)	2007-10-02
KR20020086517A (ko)	2002-11-18
HUP0204221A3 (en)	2004-04-28
KR100768331B1 (ko)	2007-10-18
CY1107769T1 (el)	2013-04-18
PL356392A1 (en)	2004-06-28
AU2001238135B2 (en)	2006-08-17
WO2001058905A1 (en)	2001-08-16
DE60129669D1 (de)	2007-09-13
IL151168A0 (en)	2003-04-10
EP1255759A1 (de)	2002-11-13
CA2400614A1 (en)	2001-08-16
RU2267492C2 (ru)	2006-01-10
CZ20022683A3 (cs)	2003-01-15
DE60129669T2 (de)	2008-05-21
RU2002124134A (ru)	2004-01-10
NO20023769L (no)	2002-10-10
BR0108279A (pt)	2002-11-05
CZ300326B6 (cs)	2009-04-22
CN1230437C (zh)	2005-12-07
JP2003522190A (ja)	2003-07-22
MXPA02007767A (es)	2002-10-23
JP5102925B2 (ja)	2012-12-19
NO20023769D0 (no)	2002-08-09
HU229511B1 (en)	2014-01-28
ES2290114T3 (es)	2008-02-16
EP1255759B1 (de)	2007-08-01
EP1255759A4 (de)	2004-11-03
CA2400614C (en)	2010-10-19
NO328648B1 (no)	2010-04-19
AU3813501A (en)	2001-08-20
DK1255759T3 (da)	2007-12-17
CN1425017A (zh)	2003-06-18
IL151168A (en)	2008-11-03
NZ520635A (en)	2004-05-28
HUP0204221A2 (hu)	2003-04-28

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2007-12-15

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