ATE366803T1 - Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit - Google Patents

Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit

Info

Publication number
ATE366803T1
ATE366803T1 AT00960038T AT00960038T ATE366803T1 AT E366803 T1 ATE366803 T1 AT E366803T1 AT 00960038 T AT00960038 T AT 00960038T AT 00960038 T AT00960038 T AT 00960038T AT E366803 T1 ATE366803 T1 AT E366803T1
Authority
AT
Austria
Prior art keywords
cell viability
cytokine production
improved cell
high cytokine
pkr
Prior art date
Application number
AT00960038T
Other languages
English (en)
Inventor
Allan Lau
Laura Browning
Michael Kiefer
Original Assignee
Genetrol Biotherapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetrol Biotherapeutics filed Critical Genetrol Biotherapeutics
Application granted granted Critical
Publication of ATE366803T1 publication Critical patent/ATE366803T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00960038T 1999-09-08 2000-09-08 Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit ATE366803T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15285499P 1999-09-08 1999-09-08

Publications (1)

Publication Number Publication Date
ATE366803T1 true ATE366803T1 (de) 2007-08-15

Family

ID=22544735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960038T ATE366803T1 (de) 1999-09-08 2000-09-08 Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit

Country Status (8)

Country Link
EP (1) EP1214399B1 (de)
JP (1) JP2003509025A (de)
AT (1) ATE366803T1 (de)
AU (1) AU7126000A (de)
CA (1) CA2383563A1 (de)
DE (1) DE60035515T2 (de)
HK (1) HK1048135A1 (de)
WO (1) WO2001018185A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031859A1 (en) * 1999-09-08 2001-10-18 Lau Allan S. High level cytokine production with enhanced cell viability
ATE313634T1 (de) * 1999-09-27 2006-01-15 Genentech Inc Verfahren zur herstellung von rekombinanten proteinen mittels inhibitoren von apoptose
CA2422060A1 (en) * 2000-09-12 2002-03-21 Genetrol Biotherapeutics, Inc. Compositions comprising mixtures of human cytokines and methods of producing the same
AU2001290855A1 (en) 2000-09-14 2002-03-26 Genetrol Biotherapeutics, Inc. Method and cell composition for screening compounds for anti-inflammatory activity
US7678570B2 (en) 2004-03-01 2010-03-16 Kitakyushu Foundation For The Advancement Of Industry, Science And Technology Human cell strains for protein production, provided by selecting strains with high intracellular protein and mutating with carcinogens
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
EP2540820B1 (de) 2005-12-09 2018-01-10 Academisch Medisch Centrum bij de Universiteit van Amsterdam Mittel und verfahren zur beeinflussung der stabilität von antikörper-produzierenden zellen
CA2768207C (en) 2009-07-15 2019-12-03 Aimm Therapeutics B.V. Means and methods for producing high affinity antibodies
RU2585153C2 (ru) 2010-12-02 2016-05-27 Аимм Терапьютикс Б.В. Средства и способы получения высокоаффинных антител
BR112016017597A2 (pt) 2014-01-31 2017-08-08 Aimm Therapeutics Bv Métodos para produzir uma célula b, para selecionar pelo menos uma célula b, para produzir anticorpos específicos para um antígeno de interesse e para identificar pelo menos uma mutação na sequência de aminoácido da cadeia pesada e/ou cadeia leve de um anticorpo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
WO1998000013A1 (en) * 1996-06-28 1998-01-08 The Regents Of The University Of California Enhancement of cancer cell death

Also Published As

Publication number Publication date
WO2001018185A1 (en) 2001-03-15
CA2383563A1 (en) 2001-03-15
AU7126000A (en) 2001-04-10
HK1048135A1 (zh) 2003-03-21
EP1214399A1 (de) 2002-06-19
EP1214399B1 (de) 2007-07-11
DE60035515D1 (de) 2007-08-23
DE60035515T2 (de) 2008-04-17
JP2003509025A (ja) 2003-03-11

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Legal Events

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