ATE362546T1 - Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül - Google Patents
Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekülInfo
- Publication number
- ATE362546T1 ATE362546T1 AT96932411T AT96932411T ATE362546T1 AT E362546 T1 ATE362546 T1 AT E362546T1 AT 96932411 T AT96932411 T AT 96932411T AT 96932411 T AT96932411 T AT 96932411T AT E362546 T1 ATE362546 T1 AT E362546T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid molecule
- repeat sequence
- multiple copies
- probe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US559095P | 1995-10-12 | 1995-10-12 | |
| US761695P | 1995-11-28 | 1995-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362546T1 true ATE362546T1 (de) | 2007-06-15 |
Family
ID=26674516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96932411T ATE362546T1 (de) | 1995-10-12 | 1996-10-10 | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6514693B1 (de) |
| EP (1) | EP0870055B1 (de) |
| AT (1) | ATE362546T1 (de) |
| DE (1) | DE69637086T2 (de) |
| WO (1) | WO1997014026A2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350853B1 (en) | 1993-04-26 | 2002-02-26 | Peter E. Nielsen | Conjugated peptide nucleic acids having enhanced cellular uptake |
| US6169169B1 (en) * | 1994-05-19 | 2001-01-02 | Dako A/S | PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis |
| DE69637086T2 (de) * | 1995-10-12 | 2008-01-10 | Lansdorp, Peter M., Vancouver | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
| US5888733A (en) * | 1995-11-16 | 1999-03-30 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
| US6015710A (en) * | 1996-04-09 | 2000-01-18 | The University Of Texas System | Modulation of mammalian telomerase by peptide nucleic acids |
| EP0878552A1 (de) * | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molekularer Nachweis von chromosomalen Veränderungen |
| JP2001501975A (ja) * | 1997-05-28 | 2001-02-13 | ペーター・エー・ニールセン | 亢進した細胞取り込みを有する結合ペプチド核酸 |
| US7193128B2 (en) | 1997-06-03 | 2007-03-20 | Chromatin, Inc. | Methods for generating or increasing revenues from crops |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US7119250B2 (en) | 1997-06-03 | 2006-10-10 | The University Of Chicago | Plant centromere compositions |
| US7227057B2 (en) | 1997-06-03 | 2007-06-05 | Chromatin, Inc. | Plant centromere compositions |
| US7235716B2 (en) | 1997-06-03 | 2007-06-26 | Chromatin, Inc. | Plant centromere compositions |
| WO1999022018A2 (en) | 1997-10-27 | 1999-05-06 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US6361942B1 (en) | 1998-03-24 | 2002-03-26 | Boston Probes, Inc. | Method, kits and compositions pertaining to detection complexes |
| EP1078098A1 (de) * | 1998-05-04 | 2001-02-28 | Dako A/S | Verfahren und sonden zur detektion chromosomaler aberrationen |
| EP1978351B1 (de) | 1998-05-16 | 2011-11-30 | Life Technologies Corporation | Instrument zur Überwachung der Polymerase-Kettenreaktion von DNS |
| US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
| US6664045B1 (en) | 1998-06-18 | 2003-12-16 | Boston Probes, Inc. | PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms |
| US20030144225A1 (en) * | 2001-12-28 | 2003-07-31 | Karras James G. | Antisense modulation of macrophage inflammatory protein 3-alpha expression |
| US7981599B1 (en) | 1998-07-31 | 2011-07-19 | Boston Probes, Inc. | Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair |
| US7989202B1 (en) | 1999-03-18 | 2011-08-02 | The University Of Chicago | Plant centromere compositions |
| US7060432B1 (en) | 1999-06-15 | 2006-06-13 | Applera Corporation | Methods for the detection, identification, and/or enumeration of yeast, particularly in wine |
| US6541202B1 (en) | 1999-10-13 | 2003-04-01 | Research & Development Institute, Inc. | Telomerase reverse transcriptase (TERT) genes from Candida albicans |
| WO2003027328A2 (en) | 2001-09-24 | 2003-04-03 | Boston Probes, Inc. | Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid |
| EP1585974B1 (de) | 2003-01-24 | 2013-02-27 | University of Utah | Verfahren zum vorhersagen des sterblichkeitsrisikos durch bestimmen der telomerlänge |
| MXPA06009225A (es) | 2004-02-23 | 2007-03-08 | Chromatin Inc | Plantas modificadas con mini-cromosomas. |
| WO2005111235A2 (en) | 2004-05-04 | 2005-11-24 | Dak Denmark A/S | Methods for detecting chromosome aberrations |
| EP1809763A2 (de) * | 2004-08-31 | 2007-07-25 | Board of Regents, The University of Texas System | Diagnose und prognose von krebs auf der grundlage der auf zytologischen präparaten gemessenen telomerlänge |
| US8407013B2 (en) | 2005-06-07 | 2013-03-26 | Peter K. Rogan | AB initio generation of single copy genomic probes |
| US7734424B1 (en) * | 2005-06-07 | 2010-06-08 | Rogan Peter K | Ab initio generation of single copy genomic probes |
| US8222028B2 (en) | 2005-09-08 | 2012-07-17 | Chromatin, Inc. | Plants modified with mini-chromosomes |
| US20070238104A1 (en) * | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | Competitive oligonucleotides |
| US8614089B2 (en) | 2007-03-15 | 2013-12-24 | Chromatin, Inc. | Centromere sequences and minichromosomes |
| US8093063B2 (en) * | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
| KR101072900B1 (ko) * | 2007-12-04 | 2011-10-17 | 주식회사 파나진 | 고정화된 펩티드핵산 프로브를 사용한 표적핵산의 선택적 표지 및 검출 방법 |
| US8084203B2 (en) * | 2008-05-12 | 2011-12-27 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population |
| US20090298709A1 (en) * | 2008-05-28 | 2009-12-03 | Affymetrix, Inc. | Assays for determining telomere length and repeated sequence copy number |
| US8877723B2 (en) | 2008-10-17 | 2014-11-04 | Geron Corporation | Method for identification of sensitivity of a patient to telomerase inhibition therapy |
| CN102439171B (zh) | 2008-12-22 | 2017-07-14 | 犹他大学研究基金会 | 单色多重定量pcr |
| CA2767724A1 (en) | 2009-07-23 | 2011-01-27 | Chromatin, Inc. | Sorghum centromere sequences and minichromosomes |
| US9926592B2 (en) | 2011-11-14 | 2018-03-27 | Carnegie Mellon University | Gamma-PNA miniprobes for fluorescent labeling |
| US20130183666A1 (en) * | 2012-01-18 | 2013-07-18 | Marc N. Feiglin | Partial genotyping by differential hybridization |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| ES2762860T3 (es) | 2013-05-22 | 2020-05-26 | Telomere Diagnostics Inc | Medidas de abundancia de telómeros cortos |
| US9476884B2 (en) | 2013-10-04 | 2016-10-25 | University Of Massachusetts | Hybridization- independent labeling of repetitive DNA sequence in human chromosomes |
| WO2015179557A1 (en) * | 2014-05-20 | 2015-11-26 | Sens Foundation, Inc. | High throughput telomeric circle assay |
| BR112017014116A2 (pt) | 2014-12-30 | 2018-03-06 | Telomere Diagnostics Inc | pcr quantitativo multiplex |
| US20230183780A1 (en) | 2016-07-25 | 2023-06-15 | InVivo BioTech Services GmbH | Dna probes for in situ hybridization on chromosomes |
| CN108004299B (zh) * | 2017-10-23 | 2021-07-06 | 济南海湾生物工程有限公司 | 一种使用基因组dna测定端粒长度的荧光定量原位杂交(q-fish)方法 |
| FR3085964B1 (fr) * | 2018-09-18 | 2023-09-01 | Cell Env | Procede a haut debit pour detecter des aberrations chromosomiques et/ou des aberrations de telomeres |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3650349T2 (de) | 1985-03-15 | 1995-12-14 | Antivirals Inc | Immunotestmittel für polynukleotid und verfahren. |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US6228982B1 (en) | 1992-05-22 | 2001-05-08 | Benget Norden | Double-stranded peptide nucleic acids |
| US5830644A (en) * | 1992-05-13 | 1998-11-03 | Geron Corporation | Method for screening for agents which increase telomerase activity in a cell |
| US5489508A (en) * | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| DE4216949C2 (de) | 1992-05-22 | 1997-07-24 | Christoph Prof Dr Dr Cremer | Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben |
| GB9211979D0 (en) | 1992-06-05 | 1992-07-15 | Buchard Ole | Uses of nucleic acid analogues |
| WO1994000598A1 (en) * | 1992-06-19 | 1994-01-06 | Northwestern University | Method of detecting amplified nucleic acid sequences in cells by flow cytometry |
| US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| US5464945A (en) * | 1992-08-28 | 1995-11-07 | Hoffmann-La Roche Inc. | Oligonucleotide probes specific for the human alpha satellite locus |
| US5472842A (en) * | 1993-10-06 | 1995-12-05 | The Regents Of The University Of California | Detection of amplified or deleted chromosomal regions |
| WO1995013382A1 (en) * | 1993-11-12 | 1995-05-18 | Geron Corporation | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US6169169B1 (en) | 1994-05-19 | 2001-01-02 | Dako A/S | PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis |
| US5741677A (en) | 1995-06-07 | 1998-04-21 | Geron Corporation | Methods for measuring telomere length |
| DE69637086T2 (de) * | 1995-10-12 | 2008-01-10 | Lansdorp, Peter M., Vancouver | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
-
1996
- 1996-10-10 DE DE69637086T patent/DE69637086T2/de not_active Expired - Lifetime
- 1996-10-10 AT AT96932411T patent/ATE362546T1/de not_active IP Right Cessation
- 1996-10-10 EP EP96932411A patent/EP0870055B1/de not_active Expired - Lifetime
- 1996-10-10 WO PCT/CA1996/000676 patent/WO1997014026A2/en active IP Right Grant
- 1996-10-11 US US08/730,635 patent/US6514693B1/en not_active Expired - Lifetime
-
2002
- 2002-04-25 US US10/132,002 patent/US20030022204A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997014026A3 (en) | 1997-07-24 |
| US6514693B1 (en) | 2003-02-04 |
| EP0870055A2 (de) | 1998-10-14 |
| WO1997014026A2 (en) | 1997-04-17 |
| DE69637086T2 (de) | 2008-01-10 |
| US20030022204A1 (en) | 2003-01-30 |
| EP0870055B1 (de) | 2007-05-16 |
| DE69637086D1 (de) | 2007-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |