ATE359071T1 - Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen - Google Patents

Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen

Info

Publication number
ATE359071T1
ATE359071T1 AT98923529T AT98923529T ATE359071T1 AT E359071 T1 ATE359071 T1 AT E359071T1 AT 98923529 T AT98923529 T AT 98923529T AT 98923529 T AT98923529 T AT 98923529T AT E359071 T1 ATE359071 T1 AT E359071T1
Authority
AT
Austria
Prior art keywords
disease
fibrils
amyloidoses
composition
treating alzheimer
Prior art date
Application number
AT98923529T
Other languages
English (en)
Inventor
Gerardo Castillo
Alan D Snow
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21944344&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE359071(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE359071T1 publication Critical patent/ATE359071T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98923529T 1997-05-15 1998-05-15 Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen ATE359071T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4660297P 1997-05-15 1997-05-15

Publications (1)

Publication Number Publication Date
ATE359071T1 true ATE359071T1 (de) 2007-05-15

Family

ID=21944344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98923529T ATE359071T1 (de) 1997-05-15 1998-05-15 Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen

Country Status (10)

Country Link
US (5) US6939570B1 (de)
EP (1) EP1019044B1 (de)
JP (1) JP4386470B2 (de)
AT (1) ATE359071T1 (de)
AU (1) AU7580098A (de)
CA (1) CA2289531C (de)
DE (1) DE69837551T2 (de)
DK (1) DK1019044T3 (de)
ES (1) ES2285772T3 (de)
WO (1) WO1998051302A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE359071T1 (de) * 1997-05-15 2007-05-15 Univ Washington Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen
US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US5985936A (en) * 1997-12-18 1999-11-16 Forbes Medi-Tech, Inc. Method of preventing and delaying onset of Alzheimer's disease and composition therefor
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
ID26989A (id) * 1998-03-26 2001-02-22 Phytopharm Plc Smilagenin dan anzurogenin-d untuk pengobatan penyakit alzheimer
MXPA01012390A (es) * 1999-06-02 2003-10-14 Oxford Natural Products Plc Combinacion de glucosamina con extractos herbarios de tripterygium, ligustrum y erycibe.
US6887898B1 (en) 1999-10-22 2005-05-03 Darrick S. H. L. Kim Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
WO2001030335A2 (en) * 1999-10-22 2001-05-03 The Board Of Trustees Of The University Of Illinois Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease
US7728043B2 (en) 1999-10-22 2010-06-01 Kim Darrick S H L Methods for treatment of beta-amyloid protein-induced ocular disease
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
JP3418724B2 (ja) * 2000-02-10 2003-06-23 国立医薬品食品衛生研究所長 セスキテルペノイド化合物及びそれを含む医薬
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
NZ544691A (en) 2000-11-03 2007-12-21 Proteotech Inc Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
AU2002250117B2 (en) * 2001-03-15 2007-11-29 Cognitive Clarity Inc. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
DK1372682T3 (da) * 2001-03-15 2012-08-20 Proteotech Inc Catechiner til behandling af fibrillogenese ved alzheimers sygdom, parkinsons sygdom, systemisk AA amyloidose og andre amyloide forstyrrelser
WO2003101927A1 (en) * 2002-05-31 2003-12-11 Proteotech, Inc. Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease
CA2499549C (en) * 2002-10-11 2012-01-24 Proteotech, Inc. Isolation, purification and synthesis of procyanidin b2 and uses thereof
WO2004108740A2 (en) * 2003-06-03 2004-12-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
GB0321996D0 (en) * 2003-09-19 2003-10-22 Novartis Nutrition Ag Organic compounds
EP1677801A4 (de) * 2003-10-10 2010-09-22 Sk Chemicals Co Ltd Wirksame triterpen-verbindungen zur verbesserung der hirnfunktion
DE102004018930A1 (de) * 2004-04-20 2005-11-17 Degussa Ag Verwendung eines keramischen Separators in Lithium-Ionenbatterien, die einen Elektrolyten aufweisen, der ionische Flüssigkeiten enthält
WO2005107712A1 (en) 2004-05-03 2005-11-17 Hermes Biosciences, Inc. Liposomes useful for drug delivery
BRPI0403688A (pt) * 2004-09-01 2006-05-02 Herbarium Lab Botan Ltda composto fitoterápico tópico para tratamento de herpes
US7446210B2 (en) * 2004-10-26 2008-11-04 Janssen Pharmaceutica N.V. Factor Xa compounds
CH697330B1 (de) * 2004-12-28 2008-08-29 Synthes Gmbh Zwischenwirbelprothese.
US8021701B1 (en) * 2005-04-13 2011-09-20 Perry Stephen C Composition to retard the onset of symptoms of alzheimer's disease
US8679738B2 (en) 2005-04-22 2014-03-25 The Hong Kong University Of Science And Technology Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
US9279806B2 (en) 2005-04-22 2016-03-08 The Hong Kong University Of Science And Technology Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
EP1996176B1 (de) * 2006-02-21 2010-05-19 Astrum Therapeutics Pty, Ltd. Zusammensetzungen zur verringerung des blutglukosespiegels und zur behandlung von diabetes
US8821851B2 (en) * 2006-03-23 2014-09-02 The General Hospital Corporation Inflammation-inhibitory serum factors and uses thereof
TR201908522T4 (tr) 2008-01-04 2019-07-22 The Government Of The U S A As Represented By The Secretary Dept Of Health And Human Services Kan lipidi düşürücü maddeler olarak keton gövdeleri ve keton gövde esterleri.
ES2326065B1 (es) * 2008-03-28 2010-07-08 Consejo Superior De Investigaciones Cientificas (Csic) Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple.
EP2307440A4 (de) * 2008-07-01 2012-12-19 Zacharon Pharmaceuticals Inc Heparansulfathemmer
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
JP5334508B2 (ja) * 2008-09-10 2013-11-06 Ｔｏｗａ Ｃｏｒｐｏｒａｔｉｏｎ 株式会社 高活性ｐｏａの製法
US8137666B2 (en) * 2008-11-22 2012-03-20 Academia Sinica Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses
FR2941697A1 (fr) * 2009-02-02 2010-08-06 Pf Medicament Derives de tagitinine c et f comme agents anticancereux.
AU2010258355B2 (en) 2009-06-12 2016-04-28 Generex Pharmaceuticals, Inc. Compositions and methods for prevention and treatment of coronary heart diseases
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
AU2013337308B2 (en) 2012-11-05 2018-06-21 Tdeltas Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
BR112015023334B1 (pt) 2013-03-14 2021-05-18 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services processo para produção de (r)-3hidroxibutil (r)-3-hidroxibutirato
AU2014101153A4 (en) * 2014-01-03 2014-10-23 Macau University Of Science And Technology A Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof
US10307454B2 (en) 2015-02-27 2019-06-04 Cognitive Clarity Inc. Compositions and methods for the treatment of “plaques and tangles” in humans and animals
MA42991A (fr) 2015-10-16 2018-08-22 Ipsen Biopharm Ltd Stabilisation de compositions pharmaceutiques de camptothécine
US10391135B2 (en) * 2016-09-16 2019-08-27 University Of South Florida Inhibition of formation of amyloid β-protein fibrils using cactus mucilage extracts
US10946056B2 (en) 2016-09-16 2021-03-16 University Of South Florida Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts
CN107397906A (zh) * 2017-08-24 2017-11-28 王小军 一种治疗继发性***性淀粉样变的中药
US10799551B2 (en) * 2017-09-25 2020-10-13 Amorepacific Corporation Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients
US10098922B1 (en) * 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
JP7037814B2 (ja) * 2018-03-28 2022-03-17 国立大学法人山口大学 ホルボールエステルを有効成分とする軸索の伸展剤
AU2019397260A1 (en) * 2018-12-12 2021-06-24 Cognitive Clarity Inc. Compositions and methods for the treatment of "plaques and tangles" in humans and animals
KR102583195B1 (ko) * 2020-12-10 2023-09-26 경상국립대학교산학협력단 퀴노바산을 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물
KR102509211B1 (ko) * 2021-02-01 2023-03-10 가천대학교 산학협력단 이소미트라필린, 미트라필린, 또는 이들의 약제학적으로 허용 가능한 염을 포함하는 퇴행성 신경질환의 예방 또는 치료용 약제학적 조성물
CN113797204B (zh) * 2021-11-08 2023-07-28 辽宁大学 小檗胺在制备治疗阿尔兹海默症药物中的应用
US11883457B1 (en) 2022-09-06 2024-01-30 Optigenex Inc. Method of enhancing cognition in individuals with at least normal cognition
WO2024056498A1 (en) * 2022-09-12 2024-03-21 Société des Produits Nestlé S.A. Oxindole alkaloid derivatives as inhibitors of sglt2

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302611A (en) 1980-10-07 1994-04-12 Klaus Keplinger Oxindole alkaloids having properties stimulating the immunologic system & preparation containing the same
EP0061487B1 (de) 1980-10-07 1985-05-02 KEPLINGER, Klaus Extract aus Uncaria tomentosa (WILLD.) DC. zur therapeutischen Verwendung
US5166139A (en) 1987-02-26 1992-11-24 Indena, S.P.A. Complexes of saponins and their aglycons with phospholipids and pharmaceutical and cosmetic compositions containing them
US6039949A (en) * 1997-02-27 2000-03-21 Campamed, Inc. Method of preparation and composition of a water soluble extract of the plant species uncaria
US6264994B1 (en) * 1997-05-15 2001-07-24 University Of Washington Compositions for treating alzheimer's disease and other amyloidoses
US6346280B1 (en) * 1997-05-15 2002-02-12 University Of Washington Composition and methods for inhibiting the formation of brain amyloid deposits
ATE359071T1 (de) * 1997-05-15 2007-05-15 Univ Washington Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen
NZ544691A (en) * 2000-11-03 2007-12-21 Proteotech Inc Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants

Also Published As

Publication number Publication date
US6607758B2 (en) 2003-08-19
US20040086585A1 (en) 2004-05-06
WO1998051302A1 (en) 1998-11-19
JP2002508752A (ja) 2002-03-19
JP4386470B2 (ja) 2009-12-16
US20040076698A1 (en) 2004-04-22
CA2289531C (en) 2009-09-29
EP1019044A1 (de) 2000-07-19
US7754250B2 (en) 2010-07-13
US7029710B2 (en) 2006-04-18
EP1019044B1 (de) 2007-04-11
ES2285772T3 (es) 2007-11-16
US20080206162A1 (en) 2008-08-28
EP1019044A4 (de) 2004-01-07
DK1019044T3 (da) 2007-08-06
DE69837551T2 (de) 2007-12-20
DE69837551D1 (de) 2007-05-24
CA2289531A1 (en) 1998-11-19
US6939570B1 (en) 2005-09-06
AU7580098A (en) 1998-12-08
US20010055630A1 (en) 2001-12-27

Similar Documents

Publication Publication Date Title
DE69837551D1 (de) Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen
ATE17079T1 (de) Praeparat zur behandlung von wunden der hautoberflaeche und verfahren zur herstellung des praeparats.
DE69636343D1 (de) Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen
DE69006684D1 (de) Verwendung einer Zusammensetzung zur Herstellung eines Arzneimittels zur Behandlung der Symptome der Unenthaltsamkeit.
ATE355374T1 (de) Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
DE69931159D1 (de) Antimikrobielle zusammensetzungen enthaltend taurolidin, zitronensäure und natriumzitrat
DE69230112D1 (de) Fortschrittliches arzneistoffabgabesystem und verfahren zur behandlung von psychiatrischen, neurologischen und anderen erkrankungen mit carbamazepin
DE69903750D1 (de) Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten
ATE375341T1 (de) Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen
ATE71629T1 (de) Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels.
UA35567C2 (uk) Фармацевтичний препарат для лікування хворих з порушеннями функції коагуляції, спосіб лікування таких хворих, спосіб одержання фармацевтичного препарату
DE59508961D1 (de) Verwendung von weihrauch zur behandlung der alzheimer-krankheit
ATE217197T1 (de) Verwendung von hyaluronsäure und eines nsaid zur herstellung eines arzneimittels zur behandlung von krankheiten der mucosa
DE69602412D1 (de) Ophthalmische Zubereitung zur Behandlung oder Prävention von trockenem Auge und Krankheiten, die dadurch verursacht werden, enthaltend 12-Sulfodehydroabietsäure
WO1998025573A3 (en) The use of celastrol to treat alzheimer's disease
DE69917074D1 (de) Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten
AU1870097A (en) Use of a medicament and use of mixture of substances to produce a medicament
DE69516110T2 (de) Verwendung von riluzol zur behandlung mitochondrialer erkrankungen
DE60005952T8 (de) Lösliche hla-g enthaltende zusammensetzungen zur behandlung entzündlicher hautkrankheiten
DE69733169D1 (de) Verwendung von Alpha-1-Adrenorezeptor-Antagonisten zur Herstellung eines Medikaments für die Vorbeugung und die Behandlung von Krebs
DE69007065T2 (de) Verwendung von Diadenosin-5',5'''-p1,p4-tetraphosphat zur Herstellung eines Arzneimittels zur Behandlung von Herzkrankheiten.
NO975177D0 (no) Farmasöytiske sammensetninger for behandling av alkoholavhengighet
ATE131729T1 (de) 3,5-diiod-l-thyronin zur tsh-suppression und behandlung von struma
DE69610045D1 (de) Verwendung eines Rohpflanzenextraktes zur Herstellung eines Arzneimittels zur Behandlung von HIV-Infektionen
DE60121978D1 (de) 7-CHLOR-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON SCHMERZEN

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1019044

Country of ref document: EP