ATE344230T1 - Triphenylbutenderivate zur behandlung von neurologischen störungen - Google Patents

Triphenylbutenderivate zur behandlung von neurologischen störungen

Info

Publication number
ATE344230T1
ATE344230T1 AT99954098T AT99954098T ATE344230T1 AT E344230 T1 ATE344230 T1 AT E344230T1 AT 99954098 T AT99954098 T AT 99954098T AT 99954098 T AT99954098 T AT 99954098T AT E344230 T1 ATE344230 T1 AT E344230T1
Authority
AT
Austria
Prior art keywords
treatment
neurological disorders
triphenyl
butene derivatives
butene
Prior art date
Application number
AT99954098T
Other languages
English (en)
Inventor
Richard Alan Keith
Timothy Martin Piser
Michael Thaddeus Klimas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE344230T1 publication Critical patent/ATE344230T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
AT99954098T 1998-11-04 1999-10-29 Triphenylbutenderivate zur behandlung von neurologischen störungen ATE344230T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9824207.6A GB9824207D0 (en) 1998-11-04 1998-11-04 Neurological disorders

Publications (1)

Publication Number Publication Date
ATE344230T1 true ATE344230T1 (de) 2006-11-15

Family

ID=10841850

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99954098T ATE344230T1 (de) 1998-11-04 1999-10-29 Triphenylbutenderivate zur behandlung von neurologischen störungen

Country Status (9)

Country Link
US (1) US6489481B1 (de)
EP (1) EP1127045B1 (de)
JP (1) JP2002528489A (de)
AT (1) ATE344230T1 (de)
AU (1) AU1054200A (de)
DE (1) DE69933885T2 (de)
ES (1) ES2274645T3 (de)
GB (1) GB9824207D0 (de)
WO (1) WO2000025767A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7710744B2 (en) * 2004-10-11 2010-05-04 Stmicroelectronics S.R.L. Method for controlling a full bridge converter with a current-doubler
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
US8062588B2 (en) * 2006-03-22 2011-11-22 Zimek Technologies Ip, Llc Ultrasonic sanitation device and associated methods
JP5382633B2 (ja) * 2006-05-25 2014-01-08 学校法人順正学園 脳血管性認知症の予防または治療薬
US20090291134A1 (en) * 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
JP7325104B2 (ja) * 2016-07-27 2023-08-14 ケース ウェスタン リザーブ ユニバーシティ ミエリン形成を促進する化合物および方法
JP7282028B2 (ja) 2017-06-02 2023-05-26 富士フイルム富山化学株式会社 脳萎縮予防または治療剤
CN110691593B (zh) 2017-06-02 2023-05-02 富士胶片富山化学株式会社 脊髓小脑变性症预防或治疗剂
US11666551B2 (en) 2017-06-02 2023-06-06 Fujifilm Toyama Chemical Co., Ltd. Agent for reducing amount of amyloid β protein
EP3636262A4 (de) 2017-06-02 2020-06-10 FUJIFILM Toyama Chemical Co., Ltd. Mittel zur prävention und/oder behandlung von demenz vom alzheimertyp
CN109293519B (zh) * 2017-07-25 2021-09-28 北京斯利安药业有限公司 一种枸橼酸他莫昔芬晶型a的制备方法
WO2019088083A1 (ja) * 2017-10-30 2019-05-09 富士フイルム富山化学株式会社 エモパミル結合タンパク質結合剤およびその利用
US11325883B2 (en) 2017-11-22 2022-05-10 Temple University—Of the Commonwealth System of Higher Education Functionalized N,N-dialkylamino phenyl ethers and their method of use
CN113365641A (zh) * 2018-09-12 2021-09-07 路易斯安那泽维尔大学 ***受体靶向拮抗剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (de) * 1962-09-13
US3288806A (en) * 1964-03-23 1966-11-29 Parke Davis & Co Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes
DE2860900D1 (en) * 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
ATE2423T1 (de) * 1978-11-07 1983-03-15 Imperial Chemical Industries Plc 1-acyloxyphenyl-1,2-diphenylalken-derivate, verfahren zu deren herstellung und eine diese derivate enthaltende pharmazeutische zusammensetzung.
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
DE4320896A1 (de) * 1993-06-24 1995-01-05 Denecke Rainer Dr Med Vet Präparat zur Therapie und Prophylaxe von Demenz-Erkrankungen
JPH11510479A (ja) * 1995-06-07 1999-09-14 ネオルックス コーポレイション タモキシフェン類似体による心臓血管疾病の予防及び治療
IL120269A0 (en) * 1996-02-28 1997-06-10 Pfizer 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease
AU7260398A (en) * 1997-04-28 1998-11-24 University Of British Columbia, The Method and composition for modulating amyloidosis
HUP0002852A3 (en) * 1997-08-15 2001-11-28 Univ Durham A method of preventing or treating estrogen-dependent diseases and disorders using triphenil-ethylene derivatives
EP0976404A3 (de) * 1998-07-30 2001-06-27 Pfizer Products Inc. Pharmazeutische Zubereitung zur Vorbeugung und Behandlung von kognitiven Störungen bei Säugetieren

Also Published As

Publication number Publication date
AU1054200A (en) 2000-05-22
EP1127045B1 (de) 2006-11-02
EP1127045A2 (de) 2001-08-29
DE69933885D1 (de) 2006-12-14
ES2274645T3 (es) 2007-05-16
WO2000025767A3 (en) 2000-09-28
US6489481B1 (en) 2002-12-03
DE69933885T2 (de) 2007-05-24
WO2000025767A2 (en) 2000-05-11
JP2002528489A (ja) 2002-09-03
GB9824207D0 (en) 1998-12-30

Similar Documents

Publication Publication Date Title
ES2191048T3 (es) Derivados de oxazolidinona y compuestos farmaceuticos que los contienen.
DE60112609D1 (en) Pyrazolopyridine
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
ATE337316T1 (de) Imidazo 1,2-aöpyridin-derivate zur prophylaxe und behandlung von herpes-infektionen
BR0108893B1 (pt) composiÇço farmacÊutica contendo derivados de azetidina, composto derivado de azetidina, e, processo para a preparaÇço de compostos.
BG104998A (en) Isothiazole derivatives useful as anticancer agents
MXPA04001016A (es) Derivados de sulfonamida como inhibidores de la gamma secretasa.
ES2243579T3 (es) Derivados de pirazolopirideno.
EA200500174A1 (ru) Новые производные бензимидазола, полезные в качестве антипролиферативных агентов
YU95102A (sh) Supstituisani biciklični derivati u lečenju abnormalnog rasta ćelija
RU2088589C1 (en) Derivatives of 17 beta-substituted-4-aza-5-5 alpha-androstane-3-ones, methods of synthesis of compounds, pharmaceutical composition, compound 4
DK1029853T3 (da) Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
SE9903760D0 (sv) New compounds
HRP20050390A2 (en) Substituted benzoxazinones and uses thereof
ATE344230T1 (de) Triphenylbutenderivate zur behandlung von neurologischen störungen
WO1999020606A3 (en) Piperidines and piperazines as platelet aggregation inhibitors
NO20003018L (no) Triazinangiogenese-inhibitorer
ES2168304T3 (es) Derivados del taxol.
RU94036745A (ru) Производные галантамина и фармацевтическая композиция
EE200000472A (et) Kasvajavastased toimeained
MY138466A (en) Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders
ATE297904T1 (de) Halo-alkoxycarbonylverbindungen
DE69410614T2 (de) Bis-naphthalimide für die behandlung von krebs
MXPA05010783A (es) Derivados antimicrobianos de [3.1.0] biciclohexilfenil-oxazolidinona y analogos.
ATE274515T1 (de) Pyrazolopyridinderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties