ATE338762T1 - Zusammensetzungen und methoden für die verknüpfung von endothelzellen - Google Patents
Zusammensetzungen und methoden für die verknüpfung von endothelzellenInfo
- Publication number
- ATE338762T1 ATE338762T1 AT92911299T AT92911299T ATE338762T1 AT E338762 T1 ATE338762 T1 AT E338762T1 AT 92911299 T AT92911299 T AT 92911299T AT 92911299 T AT92911299 T AT 92911299T AT E338762 T1 ATE338762 T1 AT E338762T1
- Authority
- AT
- Austria
- Prior art keywords
- sialyl
- methods
- compositions
- endothelial cells
- present
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000002889 endothelial cell Anatomy 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 108010024212 E-Selectin Proteins 0.000 abstract 2
- 102100023471 E-selectin Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102000003800 Selectins Human genes 0.000 abstract 2
- 108090000184 Selectins Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000000265 leukocyte Anatomy 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108010092694 L-Selectin Proteins 0.000 abstract 1
- 102000016551 L-selectin Human genes 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
- 108010035766 P-Selectin Proteins 0.000 abstract 1
- 102100023472 P-selectin Human genes 0.000 abstract 1
- 230000002939 deleterious effect Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68803791A | 1991-04-19 | 1991-04-19 | |
US72177191A | 1991-06-25 | 1991-06-25 | |
US72116091A | 1991-06-26 | 1991-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE338762T1 true ATE338762T1 (de) | 2006-09-15 |
Family
ID=27418500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92911299T ATE338762T1 (de) | 1991-04-19 | 1992-04-17 | Zusammensetzungen und methoden für die verknüpfung von endothelzellen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0580763B1 (de) |
JP (1) | JPH0826045B2 (de) |
AT (1) | ATE338762T1 (de) |
AU (1) | AU1926692A (de) |
CA (1) | CA2108786A1 (de) |
DE (1) | DE69233654D1 (de) |
WO (1) | WO1992018610A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
WO1992008490A1 (en) * | 1990-11-16 | 1992-05-29 | The Board Of Trustees Of The Leland Stanford Junior University | Skin-associated lymphocytes and markers |
IE914075A1 (en) * | 1990-11-23 | 1992-06-03 | Gen Hospital Corp | Inhibition of cell adhesion protein-carbohydrate¹interactions |
EP0668871A1 (de) * | 1991-05-03 | 1995-08-30 | The Rockefeller University | Homologien in der aminosaüre-sequenz zwischen peptiden der selectine und peptiden des b.pertussis-toxin, antikörper dagegen und pharmazeutische verbindungen |
WO1993005803A1 (en) * | 1991-09-25 | 1993-04-01 | Genetics Institute, Inc. | Anti-inflammatory selectin inhibitors |
US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
US5648458A (en) * | 1992-05-06 | 1997-07-15 | Affymax Technologies N.V. | Peptides and compounds that bind to ELAM-1 |
GB9300989D0 (en) * | 1993-01-19 | 1993-03-10 | British Bio Technology | Disaccharide ligands |
CA2157489A1 (en) * | 1993-03-04 | 1994-09-15 | Masaaki Numata | Lewis-associated compound, process for producing the same, and anti-inflammatory |
US5789385A (en) * | 1993-06-16 | 1998-08-04 | Glycomed Incorporated | Sialyl Lewisx mimetics containing phenyl backbones |
US5658880A (en) * | 1993-06-16 | 1997-08-19 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
US5750508A (en) * | 1993-06-16 | 1998-05-12 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
US5837689A (en) * | 1993-06-16 | 1998-11-17 | Glycomed Incorporated | Sialyl lewis-x mimetics containing naphthyl backbones |
US5679321A (en) * | 1993-06-17 | 1997-10-21 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
DE4408248A1 (de) * | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
EP0671409A3 (de) * | 1994-03-11 | 1996-06-12 | Hoechst Ag | Malonsäurederivate mit antiadhäsiven Eigenschaften. |
EP1428832A3 (de) * | 1995-08-03 | 2004-09-22 | The Board of Regents for the University of Oklahoma | Peptid-und O-Glycaninhibitoren von Selectin vermittelten Entzündungen |
KR19980703698A (ko) * | 1996-02-08 | 1998-12-05 | 모리따 겐조 | 암 전이 억제 항암제 물질 |
JP4599027B2 (ja) * | 2002-10-30 | 2010-12-15 | 東洋水産株式会社 | L−セレクチン結合阻害剤 |
JP5766947B2 (ja) | 2007-09-07 | 2015-08-19 | チルドレンズ ホスピタル メディカル センター | 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用 |
DK2451462T3 (en) | 2009-07-06 | 2017-12-11 | Children's Hospital Medical Center | Inhibition of inflammation with milk oligosaccharides |
WO2014130789A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
US10857167B2 (en) | 2015-04-28 | 2020-12-08 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
EP3578983A4 (de) * | 2017-02-03 | 2020-12-09 | Sumitomo Chemical Company, Limited | Verfahren zur erkennung von bauchspeicheldrüsenkrebs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4851511A (en) * | 1986-01-30 | 1989-07-25 | Fred Hutchinson Cancer Research Center | Monoclonal antibody that specifically binds to disialosyl Lea |
EP0381310A1 (de) * | 1989-01-30 | 1990-08-08 | The Biomembrane Institute | Monoklonale Antikörper gegen Tumor-assoziierte Ganglioside und Fucoganglioside sowie Produktionsmethode |
US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
EP0408859B1 (de) * | 1989-05-23 | 1995-08-09 | Otsuka Pharmaceutical Co., Ltd. | Monoklonale Antikörper gegen aktivierte endotheliale Zellen |
AU8007791A (en) * | 1990-06-15 | 1992-01-07 | Cytel Corporation | Intercellular adhesion mediators |
ATE224911T1 (de) * | 1990-07-17 | 2002-10-15 | Univ Oklahoma | Gmp-140 ligand |
NZ240316A (en) * | 1990-10-25 | 1996-12-20 | Univ Michigan | Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells |
-
1992
- 1992-04-17 CA CA002108786A patent/CA2108786A1/en not_active Abandoned
- 1992-04-17 WO PCT/US1992/003192 patent/WO1992018610A2/en active IP Right Grant
- 1992-04-17 AT AT92911299T patent/ATE338762T1/de not_active IP Right Cessation
- 1992-04-17 DE DE69233654T patent/DE69233654D1/de not_active Expired - Lifetime
- 1992-04-17 EP EP92911299A patent/EP0580763B1/de not_active Expired - Lifetime
- 1992-04-17 AU AU19266/92A patent/AU1926692A/en not_active Abandoned
- 1992-12-17 JP JP5511410A patent/JPH0826045B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1992018610A2 (en) | 1992-10-29 |
EP0580763B1 (de) | 2006-09-06 |
AU1926692A (en) | 1992-11-17 |
JPH0826045B2 (ja) | 1996-03-13 |
DE69233654D1 (de) | 2006-10-19 |
EP0580763A1 (de) | 1994-02-02 |
JPH06507927A (ja) | 1994-09-08 |
WO1992018610A3 (en) | 1993-04-01 |
CA2108786A1 (en) | 1992-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |