ATE334687T1 - Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind - Google Patents

Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind

Info

Publication number: ATE334687T1
Authority: AT; Austria
Prior art keywords: alkyl; sup; releasing hormone; cycloalkyl; conditions associated
Prior art date: 2002-11-20

Application number

AT03775585T

Other languages

English (en)

Inventor

John Gary Montana

Ian Fleming

Road Lensfiel

Reinhold Tacke

Jurgen Daiss

Original Assignee

Paradigm Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-20

Filing date

2003-11-19

Publication date

2006-08-15

2002-11-20 Priority claimed from GB0227131A external-priority patent/GB0227131D0/en

2003-05-07 Priority claimed from GB0310472A external-priority patent/GB0310472D0/en

2003-07-23 Priority claimed from GB0317283A external-priority patent/GB0317283D0/en

2003-11-19 Application filed by Paradigm Therapeutics Ltd filed Critical Paradigm Therapeutics Ltd

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE334687T1 publication Critical patent/ATE334687T1/de

Links

239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 3
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 3
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 3
229940035638 gonadotropin-releasing hormone Drugs 0.000 title abstract 3
150000003377 silicon compounds Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
201000010260 leiomyoma Diseases 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
229910052710 silicon Inorganic materials 0.000 abstract 2
239000010703 silicon Substances 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
206010016654 Fibrosis Diseases 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000004761 fibrosis Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
208000021267 infertility disease Diseases 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03775585T 2002-11-20 2003-11-19 Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind ATE334687T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0227131A GB0227131D0 (en)	2002-11-20	2002-11-20	Compounds and their use
GB0310472A GB0310472D0 (en)	2003-05-07	2003-05-07	Compounds and their use
GB0317283A GB0317283D0 (en)	2003-07-23	2003-07-23	Compounds and their use

Publications (1)

Publication Number	Publication Date
ATE334687T1 true ATE334687T1 (de)	2006-08-15

Family

ID=32329550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03775585T ATE334687T1 (de)	2002-11-20	2003-11-19	Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind

Country Status (10)

Country	Link
US (1)	US20060052344A1 (de)
EP (1)	EP1562611B1 (de)
JP (1)	JP2006510725A (de)
AT (1)	ATE334687T1 (de)
AU (1)	AU2003283607A1 (de)
CA (1)	CA2507532A1 (de)
DE (1)	DE60307313T2 (de)
DK (1)	DK1562611T3 (de)
ES (1)	ES2270129T3 (de)
WO (1)	WO2004045625A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007516192A (ja) *	2003-07-09	2007-06-21	パラダイム・セラピューティクス・リミテッド	有機ケイ素化合物およびその使用
US20080261918A1 (en) *	2004-12-17	2008-10-23	Graham Andrew Showell	Silicon Compounds and Their Use
US20090291915A1 (en) *	2004-12-17	2009-11-26	Graham Andrew Showell	Silicon Compounds and Their Use
DE102008062878A1 (de) *	2008-12-17	2010-06-24	Aicuris Gmbh & Co. Kg	Substituierte Furancarboxamide und ihre Verwendung
CN101921286B (zh) *	2009-06-15	2013-06-05	海门瑞一医药科技有限公司	一种三甲基硅乙炔的合成工艺
CN102391298A (zh) *	2011-12-27	2012-03-28	上海立科药物化学有限公司	双三甲基硅基乙炔的合成方法
US10717035B2 (en)	2017-02-13	2020-07-21	Praxair Technology, Inc.	Tunable adsorbents
WO2020252787A1 (zh) *	2019-06-21	2020-12-24	辽宁凯莱英医药化学有限公司	三甲基硅基乙炔的连续化合成***及连续化合成方法
CN114805542A (zh) *	2022-04-29	2022-07-29	江苏尤里卡生物科技有限公司	一种基于尿液中***的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA11599A (en) *	1998-08-20	2004-08-23	Agouron Pharma	Non-peptide GnRH agents, methods and intermediatesfor their preparation.
AU2003202115A1 (en) *	2002-02-12	2003-09-04	Pfizer Inc.	Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
JP2005538064A (ja) *	2002-06-13	2005-12-15	ファイザー・インク	非ペプチドＧｎＲＨ剤、医薬組成物、およびそれらの使用方法

2003
- 2003-11-19 EP EP03775585A patent/EP1562611B1/de not_active Expired - Lifetime
- 2003-11-19 JP JP2004570306A patent/JP2006510725A/ja active Pending
- 2003-11-19 ES ES03775585T patent/ES2270129T3/es not_active Expired - Lifetime
- 2003-11-19 DE DE60307313T patent/DE60307313T2/de not_active Expired - Fee Related
- 2003-11-19 DK DK03775585T patent/DK1562611T3/da active
- 2003-11-19 AT AT03775585T patent/ATE334687T1/de not_active IP Right Cessation
- 2003-11-19 AU AU2003283607A patent/AU2003283607A1/en not_active Abandoned
- 2003-11-19 WO PCT/GB2003/005015 patent/WO2004045625A1/en active IP Right Grant
- 2003-11-19 US US10/531,333 patent/US20060052344A1/en not_active Abandoned
- 2003-11-19 CA CA002507532A patent/CA2507532A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2270129T3 (es)	2007-04-01
DK1562611T3 (da)	2006-12-04
DE60307313T2 (de)	2006-12-14
EP1562611A1 (de)	2005-08-17
DE60307313D1 (de)	2006-09-14
JP2006510725A (ja)	2006-03-30
US20060052344A1 (en)	2006-03-09
EP1562611B1 (de)	2006-08-02
AU2003283607A1 (en)	2004-06-15
WO2004045625A1 (en)	2004-06-03
CA2507532A1 (en)	2004-06-03

Legal Events

Date

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Title

Description

2007-04-15

UEP

Publication of translation of european patent specification

Ref document number: 1562611

Country of ref document: EP

2009-08-15

REN

Ceased due to non-payment of the annual fee

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SE0100567D0 (sv)	2001-02-20	Compounds
HUP9802678A2 (hu)	1999-02-01	Biciklusos aminszármazékok és ezeket tartalmazó PGD2 antagonista hatású készítmények
GB0128108D0 (en)	2002-01-16	Therapeutic use
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SE0100568D0 (sv)	2001-02-20	Compounds
HUP0203971A2 (hu)	2003-03-28	Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
SE9902987D0 (sv)	1999-08-24	Novel compounds
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ATE334687T1 (de)	2006-08-15	Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind
HUP0300838A2 (hu)	2003-07-28	Új heteroarilszármazékok, eljárás az előállításukra és gyógyszerként való alkalmazásuk
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BR0315837A (pt)	2005-09-20	Derivados de amida de ácido heteroaril-hexanóico como agentes imunomoduladores
SE0101692D0 (sv)	2001-05-14	Compounds
HUP0400207A2 (hu)	2004-08-30	Helyettesített 4-amino-ciklohexanol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
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