ATE331788T1 - Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung - Google Patents

Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung

Info

Publication number: ATE331788T1
Authority: AT; Austria
Prior art keywords: disulfide; production; toxins; cell poisons; conjugate cell
Prior art date: 1999-10-22

Application number

AT00972301T

Other languages

English (en)

Inventor

David J Fitzgerald

Michael J Iadarola

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-22

Filing date

2000-10-20

Publication date

2006-07-15

2000-10-20 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE331788T1 publication Critical patent/ATE331788T1/de

Links

238000000034 method Methods 0.000 title abstract 2
239000002574 poison Substances 0.000 title 1
231100000614 poison Toxicity 0.000 title 1
239000003053 toxin Substances 0.000 abstract 3
231100000765 toxin Toxicity 0.000 abstract 3
108700012359 toxins Proteins 0.000 abstract 3
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 2
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 2
102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 2
108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 2
102100024304 Protachykinin-1 Human genes 0.000 abstract 2
101800003906 Substance P Proteins 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
238000002679 ablation Methods 0.000 abstract 1
231100000776 exotoxin Toxicity 0.000 abstract 1
239000002095 exotoxin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT00972301T 1999-10-22 2000-10-20 Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung ATE331788T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16115999P	1999-10-22	1999-10-22

Publications (1)

Publication Number	Publication Date
ATE331788T1 true ATE331788T1 (de)	2006-07-15

Family

ID=22580070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00972301T ATE331788T1 (de)	1999-10-22	2000-10-20	Disulfidkonjugierte zellgifte und verfahren zur ihrer herstellung und verwendung

Country Status (7)

Country	Link
US (1)	US6881718B1 (de)
EP (1)	EP1224290B1 (de)
AT (1)	ATE331788T1 (de)
AU (1)	AU779473B2 (de)
CA (1)	CA2388165A1 (de)
DE (1)	DE60029119D1 (de)
WO (1)	WO2001031020A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7314632B1 (en) *	1997-07-11	2008-01-01	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Pseudomonas exotoxin A-like chimeric immunogens
US20030054012A1 (en) *	2000-05-12	2003-03-20	Fitzgerald David J.	Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
DK1000163T3 (da) *	1997-07-11	2006-02-06	Us Gov Health & Human Serv	Pseudomonas-exotoksin A-lignende kimære immunogener
ATE444081T1 (de) *	1999-10-22	2009-10-15	Us Gov Health & Human Serv	Proteine-abgabe durch polare epithelzellen schichte
US8339462B2 (en)	2008-01-28	2012-12-25	DigitalOptics Corporation Europe Limited	Methods and apparatuses for addressing chromatic abberations and purple fringing
CA2571781C (en) *	2004-06-28	2015-05-12	Yeda Research And Development Co. Ltd	Chimeric proteins and uses thereof
EP1804832A4 (de)	2004-10-04	2008-12-24	Trinity Biosystems Inc	Verfahren und zusammensetzungen zur nadellosen abgabe von makromolekülen
CA2631952A1 (en)	2005-12-05	2007-06-14	Trinity Biosystems, Inc.	Methods and compositions for needleless delivery of antibodies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5668255A (en) *	1984-06-07	1997-09-16	Seragen, Inc.	Hybrid molecules having translocation region and cell-binding region
US5169933A (en) *	1988-08-15	1992-12-08	Neorx Corporation	Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
WO1990003401A1 (en) *	1988-09-30	1990-04-05	Neorx Corporation	Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages
FR2653190B1 (fr) *	1989-10-12	1994-11-18	Nacam	Barre a aptitude au flambage renforcee et son application notamment aux directions d'automobiles.
US5674980A (en)	1989-12-21	1997-10-07	Biogen Inc	Fusion protein comprising tat-derived transport moiety
DE19523287C2 (de) *	1994-06-28	1998-07-02	Usui Kokusai Sangyo Kk	Anordnung zum Verbinden eines Kraftstoff-Abzweigelementes mit einer Kraftstoff-Sammelschiene
WO1997013410A1 (en) *	1995-10-13	1997-04-17	Boston Medical Center Corporation	Hybrid molecules containing amidated polypeptide binding ligands
US5663250A (en) *	1996-05-16	1997-09-02	Shell Oil Company	Deprotection with molten salt
GB9818548D0 (en) *	1998-08-25	1998-10-21	Microbiological Res Authority	Treatment of mucas hypersecretion

2000
- 2000-10-20 AT AT00972301T patent/ATE331788T1/de not_active IP Right Cessation
- 2000-10-20 DE DE60029119T patent/DE60029119D1/de not_active Expired - Lifetime
- 2000-10-20 CA CA002388165A patent/CA2388165A1/en not_active Abandoned
- 2000-10-20 EP EP00972301A patent/EP1224290B1/de not_active Expired - Lifetime
- 2000-10-20 AU AU10982/01A patent/AU779473B2/en not_active Ceased
- 2000-10-20 WO PCT/US2000/029064 patent/WO2001031020A1/en active IP Right Grant
- 2000-10-20 US US10/110,934 patent/US6881718B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6881718B1 (en)	2005-04-19
AU1098201A (en)	2001-05-08
EP1224290A1 (de)	2002-07-24
EP1224290B1 (de)	2006-06-28
DE60029119D1 (de)	2006-08-10
WO2001031020A1 (en)	2001-05-03
CA2388165A1 (en)	2001-05-03
AU779473B2 (en)	2005-01-27

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Legal Events

Date	Code	Title	Description
2006-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties