ATE327750T1 - Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung - Google Patents
Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlungInfo
- Publication number
- ATE327750T1 ATE327750T1 AT02701418T AT02701418T ATE327750T1 AT E327750 T1 ATE327750 T1 AT E327750T1 AT 02701418 T AT02701418 T AT 02701418T AT 02701418 T AT02701418 T AT 02701418T AT E327750 T1 ATE327750 T1 AT E327750T1
- Authority
- AT
- Austria
- Prior art keywords
- benz
- prodrugs
- indole
- benzo
- tumor treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01301634 | 2001-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE327750T1 true ATE327750T1 (de) | 2006-06-15 |
Family
ID=8181736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02701418T ATE327750T1 (de) | 2001-02-22 | 2002-02-22 | Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung |
Country Status (6)
Country | Link |
---|---|
US (2) | US7192977B2 (de) |
EP (1) | EP1408960B1 (de) |
JP (1) | JP4862120B2 (de) |
AT (1) | ATE327750T1 (de) |
DE (1) | DE60211905T2 (de) |
WO (1) | WO2002067930A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
NZ536107A (en) * | 2004-10-22 | 2007-06-29 | Auckland Uniservices Ltd | Nitrobenzindoles and their use in cancer therapy |
GB0505644D0 (en) | 2005-03-18 | 2005-04-27 | Univ London Pharmacy | Analogues of the azinomycins as anti-tumour agents and as prodrugs |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
HUE035798T2 (en) * | 2008-11-03 | 2018-05-28 | Syntarga Bv | CC-1065 analogues and conjugates |
PL3056203T3 (pl) | 2010-04-21 | 2018-06-29 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
WO2015104385A2 (en) | 2014-01-10 | 2015-07-16 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs showing improved in vivo antitumor activity |
CA2935430C (en) | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs for use in treatment of endometrial cancer |
MY177390A (en) | 2014-01-10 | 2020-09-14 | Byondis Bv | Method for purifying cys-linked antibody-drug conjugates |
CN109020820B (zh) * | 2017-06-08 | 2021-06-25 | 杭州惠诺医药科技有限公司 | 一种6-溴-2-氨基萘的制备方法 |
WO2019004413A1 (ja) * | 2017-06-30 | 2019-01-03 | 東レ株式会社 | インドリン誘導体及びそれを含む細胞毒性剤 |
CN113292554A (zh) * | 2021-06-25 | 2021-08-24 | 守恒(厦门)医疗科技有限公司 | 二氢萘并[2,1-d]异噁唑酰胺类衍生物及其在抗肿瘤药物的应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4413132A (en) | 1980-11-18 | 1983-11-01 | The Upjohn Company | Antibiotic CC-1065 indoline intermediates |
GB9519490D0 (en) | 1995-09-25 | 1995-11-29 | Melvin William T | Use of a cytochrome P450 enzyme in tumour cells as a marker and target |
US6548530B1 (en) * | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
AU711974B2 (en) * | 1996-03-08 | 1999-10-28 | Scripps Research Institute, The | MCBI analogs of CC-1065 and the duocarmycins |
US5843937A (en) | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
US6060608A (en) * | 1996-05-31 | 2000-05-09 | The Scripps Research Institute | Analogs of CC-1065 and the duocarmycins |
CA2265874C (en) * | 1996-09-12 | 2007-08-28 | Cancer Research Campaign Technology Limited | Condensed n-acylindoles as antitumor agents |
JP4642226B2 (ja) | 1998-02-06 | 2011-03-02 | デ モントフォート ユニヴァーシティ | ヒドロキシル化により活性化されたプロドラッグ |
EP1409480B1 (de) * | 2001-02-22 | 2007-11-14 | The School Of Pharmacy, University Of London | Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung |
EP1408970B1 (de) * | 2001-02-22 | 2007-05-09 | School Of Pharmacy, University Of London | Indoline und tetrahydro-chinoline als prodrugs zur tumorbehandlung |
MXPA03011094A (es) * | 2001-05-31 | 2004-12-06 | Medarex Inc | Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello. |
WO2004101767A2 (en) * | 2003-05-13 | 2004-11-25 | The Scripps Research Institute | Cbi analogues of the duocarmycins and cc-1065 |
WO2005112919A2 (en) * | 2004-05-19 | 2005-12-01 | Medarex, Inc. | Self-immolative linkers and drug conjugates |
-
2002
- 2002-02-22 EP EP02701418A patent/EP1408960B1/de not_active Expired - Lifetime
- 2002-02-22 DE DE60211905T patent/DE60211905T2/de not_active Expired - Lifetime
- 2002-02-22 AT AT02701418T patent/ATE327750T1/de not_active IP Right Cessation
- 2002-02-22 WO PCT/GB2002/000801 patent/WO2002067930A1/en active IP Right Grant
- 2002-02-22 US US10/468,744 patent/US7192977B2/en not_active Expired - Lifetime
- 2002-02-22 JP JP2002567297A patent/JP4862120B2/ja not_active Expired - Fee Related
-
2007
- 2007-02-27 US US11/710,899 patent/US8017640B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60211905D1 (de) | 2006-07-06 |
US20040138246A1 (en) | 2004-07-15 |
WO2002067930A1 (en) | 2002-09-06 |
JP2004522779A (ja) | 2004-07-29 |
DE60211905T2 (de) | 2007-01-18 |
JP4862120B2 (ja) | 2012-01-25 |
US7192977B2 (en) | 2007-03-20 |
US8017640B2 (en) | 2011-09-13 |
EP1408960A1 (de) | 2004-04-21 |
US20070161669A1 (en) | 2007-07-12 |
EP1408960B1 (de) | 2006-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60223544D1 (de) | Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung | |
DE60211905D1 (de) | Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung | |
DE60220057D1 (de) | Indoline und tetrahydro-chinoline als prodrugs zur tumorbehandlung | |
FR16C0021I1 (de) | ||
PT2420234E (pt) | 1h-benzimidazole-4-carboxamidas substituídas com um carbono quaternário na posição 2 como inibidores de parp para uso no tratamento do cancro | |
MX2009004888A (es) | Inhibidores del virus de la hepatitis c. | |
WO2010003475A8 (de) | Neue pyrrolidinderivate als metap-2 inhibitoren | |
MX2009004943A (es) | Inhibidores del virus de la hepatitis c. | |
MX2009013341A (es) | Derivados de 6-(pirrolopiridinil)-pirimidinil-2-amina. | |
EP1775342A8 (de) | Antitumormittel mit minus-strang-rna-virus | |
TW200626610A (en) | Analogs of 17-hydroxywortmannin as PI3K inhibitors | |
EP3173415A3 (de) | Aktivatoren der menschlichen pyruvatkinase | |
MX2007013632A (es) | Procedimientos para preparar derivados de bencil-benceno sustituidos con glucopiranosilo y sus productos intermedios. | |
WO2006020722A3 (en) | Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting | |
TW200510333A (en) | Benzimidazole compounds | |
TW200722427A (en) | Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods | |
WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
WO2006035244A3 (en) | Ecteinascidin compounds as anti -inflammatory agents | |
WO2007067813A3 (en) | Methods and compositions for assessing alterations in gene expression patterns in clinically normal tissues obtained from heterozygous carriers of mutant genes associated with cancer and methods of use thereof | |
WO2006071966A3 (en) | Rapamycin compounds in the treatment of neurofibromatosis type 1 | |
SI1845780T1 (sl) | Uporaba derivatov metilfenidata | |
UA96745C2 (en) | PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | |
WO2006123184A3 (en) | Sulphonamido-substituted cyclohexyl sulphones for treatment of cancer | |
TW200621237A (en) | [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones | |
ATE550019T1 (de) | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |