ATE311402T1 - Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit - Google Patents
Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeitInfo
- Publication number
- ATE311402T1 ATE311402T1 AT97935053T AT97935053T ATE311402T1 AT E311402 T1 ATE311402 T1 AT E311402T1 AT 97935053 T AT97935053 T AT 97935053T AT 97935053 T AT97935053 T AT 97935053T AT E311402 T1 ATE311402 T1 AT E311402T1
- Authority
- AT
- Austria
- Prior art keywords
- solubility
- nucleic acids
- peptide nucleic
- sequence specificity
- binding affinity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/686,114 US6414112B1 (en) | 1991-05-24 | 1996-07-24 | Peptide nucleic acids having 2,6-diaminopurine nucleobases |
US08/686,113 US5766855A (en) | 1991-05-24 | 1996-07-24 | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
US08/686,116 US5714331A (en) | 1991-05-24 | 1996-07-24 | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
US08/685,484 US5719262A (en) | 1993-11-22 | 1996-07-24 | Peptide nucleic acids having amino acid side chains |
US5100297P | 1997-05-29 | 1997-05-29 | |
PCT/US1997/012811 WO1998003542A1 (en) | 1996-07-24 | 1997-07-24 | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE311402T1 true ATE311402T1 (de) | 2005-12-15 |
Family
ID=27535143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97935053T ATE311402T1 (de) | 1996-07-24 | 1997-07-24 | Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0960121B1 (de) |
JP (2) | JP3306073B2 (de) |
AT (1) | ATE311402T1 (de) |
AU (1) | AU717387B2 (de) |
CA (1) | CA2261566A1 (de) |
DE (1) | DE69734783T2 (de) |
WO (1) | WO1998003542A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985558A (en) * | 1997-04-14 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos |
DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
US6326479B1 (en) * | 1998-01-27 | 2001-12-04 | Boston Probes, Inc. | Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
US7892737B2 (en) | 2005-06-30 | 2011-02-22 | Life Technologies Corporation | Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes |
EP1954838B1 (de) | 2005-11-14 | 2014-02-26 | Life Technologies Corporation | Kodierte moleküle zur erkennung von zielanalyten |
CN101490551A (zh) | 2006-06-30 | 2009-07-22 | 阿普里拉股份有限公司 | 分析结合相互作用的方法 |
DE102006034319A1 (de) | 2006-07-21 | 2008-01-31 | Ugichem Gmbh | Chirale mit Phosponsäurester- oder Phosphonsäure- substituierte Verbindungen |
US20100284959A1 (en) * | 2008-01-23 | 2010-11-11 | Gene Arrest Ltd. | Sequence specific double-stranded dna/rna binding compounds and uses thereof |
AU2009323766B2 (en) | 2008-12-02 | 2016-10-06 | Wave Life Sciences Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
IN2012DN00720A (de) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
ES2940887T3 (es) | 2012-07-13 | 2023-05-12 | Wave Life Sciences Ltd | Método de preparación de oligonucleótidos quirales |
KR101830700B1 (ko) | 2013-11-11 | 2018-02-21 | 주식회사 파나진 | 클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법 |
US10149905B2 (en) | 2014-01-15 | 2018-12-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
DE102014007158A1 (de) * | 2014-05-16 | 2015-11-19 | Ugichem Gmbh | Neue Peptid-Nukleinsäuren-Monomere und -Oligomere |
EP3498844B1 (de) * | 2016-08-09 | 2022-09-28 | Seasun Therapeutics | Peptidnukleinsäurekomplex mit verbesserter zellpermeabilität und pharmazeutische zusammensetzung damit |
KR102262260B1 (ko) * | 2018-02-08 | 2021-06-09 | 주식회사 시선테라퓨틱스 | 엔도좀 탈출능을 갖는 펩티드 핵산 복합체 및 이의 용도 |
KR102484332B1 (ko) * | 2018-02-08 | 2023-01-04 | 주식회사 시선테라퓨틱스 | 핵산 복합체를 함유하는 피부 투과성 전달체 및 이의 용도 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS200063B1 (cs) * | 1978-08-24 | 1980-08-29 | Milan Strasak | Způsob přípravy alkylen-Ν,Ν '-bis-histidinů |
JPS6163661A (ja) * | 1984-09-05 | 1986-04-01 | Microbial Chem Res Found | ヒスタジン関連化合物 |
AU5410786A (en) * | 1985-03-04 | 1986-09-11 | Fujisawa Pharmaceutical Co., Ltd. | Amino acid derivatives and processes for preparation thereof |
US5166315A (en) * | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
JP3022967B2 (ja) * | 1985-03-15 | 2000-03-21 | アンチバイラルズ インコーポレイテッド | 立体規則性ポリヌクレオチド結合ポリマー |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
DE4408528A1 (de) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
DE19532553A1 (de) * | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
-
1997
- 1997-07-24 EP EP97935053A patent/EP0960121B1/de not_active Expired - Lifetime
- 1997-07-24 AT AT97935053T patent/ATE311402T1/de not_active IP Right Cessation
- 1997-07-24 CA CA002261566A patent/CA2261566A1/en not_active Abandoned
- 1997-07-24 DE DE69734783T patent/DE69734783T2/de not_active Expired - Fee Related
- 1997-07-24 JP JP50718698A patent/JP3306073B2/ja not_active Expired - Fee Related
- 1997-07-24 AU AU38081/97A patent/AU717387B2/en not_active Ceased
- 1997-07-24 WO PCT/US1997/012811 patent/WO1998003542A1/en active IP Right Grant
-
2001
- 2001-07-23 JP JP2001222248A patent/JP2002105059A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2261566A1 (en) | 1998-01-29 |
EP0960121B1 (de) | 2005-11-30 |
JP3306073B2 (ja) | 2002-07-24 |
DE69734783T2 (de) | 2006-08-17 |
EP0960121A1 (de) | 1999-12-01 |
DE69734783D1 (de) | 2006-01-05 |
EP0960121A4 (de) | 2003-05-28 |
JP2000503671A (ja) | 2000-03-28 |
JP2002105059A (ja) | 2002-04-10 |
WO1998003542A1 (en) | 1998-01-29 |
AU717387B2 (en) | 2000-03-23 |
AU3808197A (en) | 1998-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |