ATE310098T1 - Dna kodierend für glutaminsäure-gesteuerte chloridkanäle - Google Patents

Dna kodierend für glutaminsäure-gesteuerte chloridkanäle

Info

Publication number
ATE310098T1
ATE310098T1 AT96913285T AT96913285T ATE310098T1 AT E310098 T1 ATE310098 T1 AT E310098T1 AT 96913285 T AT96913285 T AT 96913285T AT 96913285 T AT96913285 T AT 96913285T AT E310098 T1 ATE310098 T1 AT E310098T1
Authority
AT
Austria
Prior art keywords
host cells
chloride channels
glutamic acid
dna coding
recombinant host
Prior art date
Application number
AT96913285T
Other languages
English (en)
Inventor
Doris F Cully
Joseph P Arena
Philip S Paress
Ken K Liu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE310098T1 publication Critical patent/ATE310098T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96913285T 1995-05-05 1996-05-01 Dna kodierend für glutaminsäure-gesteuerte chloridkanäle ATE310098T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/435,933 US5693492A (en) 1995-05-05 1995-05-05 DNA encoding glutamate gated chloride channels
PCT/US1996/006035 WO1996034940A1 (en) 1995-05-05 1996-05-01 Dna encoding glutamate gated chloride channels

Publications (1)

Publication Number Publication Date
ATE310098T1 true ATE310098T1 (de) 2005-12-15

Family

ID=23730421

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96913285T ATE310098T1 (de) 1995-05-05 1996-05-01 Dna kodierend für glutaminsäure-gesteuerte chloridkanäle

Country Status (8)

Country Link
US (1) US5693492A (de)
EP (1) EP0871703B1 (de)
JP (1) JP3862278B2 (de)
AT (1) ATE310098T1 (de)
CA (1) CA2220116C (de)
DE (1) DE69635455T2 (de)
ES (1) ES2250989T3 (de)
WO (1) WO1996034940A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527703A (en) * 1994-05-25 1996-06-18 Merck & Co., Inc. DNA encoding glutamate gated chloride channels
US6358701B1 (en) * 1997-08-11 2002-03-19 Merck & Co., Inc. DNA molecules encoding Ctenocephalides felis glutamate gated chloride channels
DE19819829A1 (de) * 1998-05-04 1999-11-11 Bayer Ag Nukleinsäuren, die für Acetylcholinrezeptor-Untereinheiten von Insekten kodieren
JP2003512830A (ja) * 1999-10-22 2003-04-08 メルク エンド カムパニー インコーポレーテッド シストセルカ・アメリカーナ由来のｌ−グルタミン酸依存性塩素イオンチャンネルをコードするｄｎａ分子
EP1263769B1 (de) * 2000-03-02 2012-08-08 Schering Corporation Dns-moleküle die einen chlorid-kanal in drosophila melanogaster kodieren
DE10013619A1 (de) * 2000-03-18 2001-10-11 Bayer Ag Ligandengesteuerte Anionenkanäle von Insekten
EP1294751B1 (de) * 2000-03-31 2014-03-05 Merial Limited Gaba-abhängige chloridkanäle aus dermacentor variabilis
US7267964B2 (en) * 2000-03-31 2007-09-11 Merial Limited DNA molecules encoding ligand gated ion channels from Dermacentor variabilis
PT1272503E (pt) * 2000-03-31 2011-05-02 Merial Ltd Mol?culas de adn que codificam canais de cloro activados pelo l-glutamato de rhipicephalus sanguineus
JP5134750B2 (ja) 2000-03-31 2013-01-30 メリアル・リミテツド Ｄｅｒｍａｃｅｎｔｏｒｖａｒｉａｂｉｌｉｓ由来の、リガンド依存性イオンチャネルをコードするＤＮＡ分子
US6329174B1 (en) 2000-06-13 2001-12-11 Aventis Cropscience Sa Nucleic acid encoding lepidoteran glutamate-gated chloride channel
RU2007117752A (ru) * 2004-10-13 2008-11-20 Аблинкс Н.В. (Be) Нанотела (nanobodies тм) против бета-амилоида и полипептидов, содержащих бета-амилоид, для лечения нейродегенеративных заболеваний, таких как болезнь альцгеймера
BR122013001996B1 (pt) 2005-05-18 2022-02-01 Ablynx N.V. Nanocorpos melhorados contra fator alfa de necrose tumoral
RU2433139C2 (ru) 2005-05-20 2011-11-10 Аблинкс Н.В. Nanobodies tm для лечения заболеваний, опосредованных агрегацией
EP2102244A2 (de) 2006-12-19 2009-09-23 Ablynx N.V. Gegen metalloproteinase aus der adam-familie gerichtete aminosäuresequenzen und diese enthaltende polypeptide zur behandlung von mit adam in zusammenhang stehenden krankheiten und störungen
EP2115004A2 (de) 2006-12-19 2009-11-11 Ablynx N.V. Gegen gpcrs gerichtete aminosäuresequenzen und diese enthaltende polypeptide zur behandlung von mit gpcr in zusammenhang tehenden krankheiten und erkrankungen
EP2947097A1 (de) 2008-04-07 2015-11-25 Ablynx N.V. Gegen Notch-Signalwege gerichtete Aminosäuresequenzen und Verwendungen davon
CN107011434B (zh) 2008-12-19 2021-02-19 埃博灵克斯股份有限公司 用于产生针对细胞相关抗原如p2x7、cxcr7或cxcr4的免疫球蛋白的基因免疫
AU2010233658B2 (en) 2009-04-10 2013-11-28 Ablynx Nv Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders
ES2643034T3 (es) 2009-06-05 2017-11-21 Ablynx N.V. Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias
US9644022B2 (en) 2009-11-30 2017-05-09 Ablynx N.V. Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
WO2011083140A1 (en) 2010-01-08 2011-07-14 Ablynx Nv Immunoglobulin single variable domain directed against human cxcr4
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US11840569B2 (en) 2016-11-16 2023-12-12 Ablynx N.V. T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
EP3758755A1 (de) 2018-02-26 2021-01-06 Ablynx N.V. Verbesserte, für peptidlinker kodierende nukleotidsequenzen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240921A (en) * 1990-12-12 1994-06-27 Zymogenetics Inc G protein coupled glutamate receptor (neurotransmitters), recombinant production
US5385831A (en) * 1990-12-12 1995-01-31 Zymogenetics, Inc. Method for producing a mammalian G protein coupled glutamate receptor
AU2343092A (en) * 1991-04-02 1992-12-21 Baylor College Of Medicine A high-affinity human glutamate/aspartate uptake system
GB9112504D0 (en) * 1991-06-11 1991-07-31 Merck Sharp & Dohme Cell line
WO1993007161A1 (en) * 1991-10-04 1993-04-15 Cornell Research Foundation, Inc. Molecular cloning and transformation of cyclodiene resistance
US5527703A (en) * 1994-05-25 1996-06-18 Merck & Co., Inc. DNA encoding glutamate gated chloride channels

Also Published As

Publication number Publication date
JP3862278B2 (ja) 2006-12-27
EP0871703B1 (de) 2005-11-16
US5693492A (en) 1997-12-02
CA2220116A1 (en) 1996-11-07
DE69635455T2 (de) 2006-08-03
DE69635455D1 (de) 2005-12-22
WO1996034940A1 (en) 1996-11-07
EP0871703A4 (de) 2000-03-01
CA2220116C (en) 2011-04-19
ES2250989T3 (es) 2006-04-16
JPH11506906A (ja) 1999-06-22
EP0871703A1 (de) 1998-10-21

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