ATE307803T1 - Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat - Google Patents

Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat

Info

Publication number
ATE307803T1
ATE307803T1 AT00903131T AT00903131T ATE307803T1 AT E307803 T1 ATE307803 T1 AT E307803T1 AT 00903131 T AT00903131 T AT 00903131T AT 00903131 T AT00903131 T AT 00903131T AT E307803 T1 ATE307803 T1 AT E307803T1
Authority
AT
Austria
Prior art keywords
methylpyridine
acetone
amino
ethylcyanoacetate
chlorine
Prior art date
Application number
AT00903131T
Other languages
English (en)
Inventor
Karl Grozinger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE307803T1 publication Critical patent/ATE307803T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00903131T 1999-01-22 2000-01-06 Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat ATE307803T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11670399P 1999-01-22 1999-01-22
PCT/US2000/000261 WO2000043364A1 (en) 1999-01-22 2000-01-06 Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate

Publications (1)

Publication Number Publication Date
ATE307803T1 true ATE307803T1 (de) 2005-11-15

Family

ID=22368723

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00903131T ATE307803T1 (de) 1999-01-22 2000-01-06 Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat

Country Status (8)

Country Link
US (1) US6136982A (de)
EP (1) EP1070053B1 (de)
JP (1) JP2002535310A (de)
AT (1) ATE307803T1 (de)
CA (1) CA2318412A1 (de)
DE (1) DE60023402T2 (de)
ES (1) ES2251964T3 (de)
WO (1) WO2000043364A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
CN100358871C (zh) * 2005-08-02 2008-01-02 江阴暨阳医药化工有限公司 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
CA2802831C (en) 2010-06-16 2018-11-20 Teijin Pharma Limited Controlled release coat-core tablet
WO2016118586A1 (en) * 2015-01-20 2016-07-28 Virginia Commonwealth University Lowcost, high yield synthesis of nevirapine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2082801C (en) * 1991-06-11 2003-07-08 Karl G. Grozinger Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
US5654429A (en) * 1992-11-18 1997-08-05 Boehringer Ingelheim Pharma Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
DE59409324D1 (de) * 1993-12-02 2000-06-08 Boehringer Ingelheim Pharma Verfahren zur herstellung von 3-amino-2-chlor-4-alkyl- bzw. 4-cycloalkyl-pyridine

Also Published As

Publication number Publication date
DE60023402D1 (de) 2005-12-01
CA2318412A1 (en) 2000-07-27
EP1070053A1 (de) 2001-01-24
WO2000043364A1 (en) 2000-07-27
EP1070053A4 (de) 2001-04-18
US6136982A (en) 2000-10-24
DE60023402T2 (de) 2006-04-27
ES2251964T3 (es) 2006-05-16
JP2002535310A (ja) 2002-10-22
EP1070053B1 (de) 2005-10-26

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