ATE305447T1 - NEW FATTY ACID ANALOGUES - Google Patents

NEW FATTY ACID ANALOGUES

Info

Publication number
ATE305447T1
ATE305447T1 AT01910259T AT01910259T ATE305447T1 AT E305447 T1 ATE305447 T1 AT E305447T1 AT 01910259 T AT01910259 T AT 01910259T AT 01910259 T AT01910259 T AT 01910259T AT E305447 T1 ATE305447 T1 AT E305447T1
Authority
AT
Austria
Prior art keywords
carbon
fatty acid
alkyl
coor2
proviso
Prior art date
Application number
AT01910259T
Other languages
German (de)
Inventor
Rolf Berge
Leiv K Sydnes
Jon Songstad
Original Assignee
Thia Medica As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thia Medica As filed Critical Thia Medica As
Application granted granted Critical
Publication of ATE305447T1 publication Critical patent/ATE305447T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to novel fatty acid analogous of the general formula (I): R1—[xi—CH2]n—COOR2 wherein R1 is: a C6-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C6-C24 alkyne, and/or a C6-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (ω-1) carbon and the (ω-2) carbon, or between the (ω-2) carbon and the (ω-3) carbon, or between the (ω-3) carbon and the (ω-4) carbon, a salt, prodrug or complex thereof, which can be used for the treatment and/or prevention of syndrome X, obesity, hypertension, fatty liver, diabetes, hyperglycaemia, hyperinsulinemia and stenosis. Further, the invention relates to a nutritional composition comprising said fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal.
AT01910259T 2000-03-03 2001-03-02 NEW FATTY ACID ANALOGUES ATE305447T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20001123A NO328803B1 (en) 2000-03-03 2000-03-03 New fatty acid analogues
PCT/NO2001/000082 WO2001068582A1 (en) 2000-03-03 2001-03-02 Novel fatty acid analogous

Publications (1)

Publication Number Publication Date
ATE305447T1 true ATE305447T1 (en) 2005-10-15

Family

ID=19910832

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01910259T ATE305447T1 (en) 2000-03-03 2001-03-02 NEW FATTY ACID ANALOGUES

Country Status (18)

Country Link
US (1) US7902399B2 (en)
EP (1) EP1265838B9 (en)
JP (1) JP5122050B2 (en)
KR (3) KR100857626B1 (en)
CN (1) CN1283611C (en)
AT (1) ATE305447T1 (en)
AU (2) AU2001237835B2 (en)
BR (1) BR0108950A (en)
CA (1) CA2401757C (en)
DE (1) DE60113663T2 (en)
DK (1) DK1265838T3 (en)
ES (1) ES2250360T3 (en)
HK (1) HK1050182A1 (en)
MX (1) MX236472B (en)
NO (1) NO328803B1 (en)
NZ (1) NZ521137A (en)
RU (1) RU2288215C2 (en)
WO (1) WO2001068582A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20004844L (en) * 2000-09-27 2002-05-10 Thia Medica As Fatty acid analogues for the treatment of proliferative skin diseases
CN100351259C (en) * 2002-06-20 2007-11-28 Icvec有限公司 Sulfur-containing phospholipid derivatives
CA2554735A1 (en) * 2004-01-30 2005-08-11 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
NO324533B1 (en) * 2004-07-19 2007-11-19 Thia Medica As Material prepared from a combination of non-β-oxidizable fatty acid analogues and a protein material, as well as the use thereof.
MX2007000813A (en) * 2004-07-19 2007-06-05 Thia Medica As Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities.
ES2733353T3 (en) 2007-11-09 2019-11-28 Basf As Lipid compounds for use in cosmetic products, as a food supplement or as a medicine
NO20075894L (en) * 2007-11-15 2009-05-18 Thia Medica As Reduced maturation in fish
EP2147910A1 (en) * 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
CA2760877C (en) 2009-05-08 2020-09-08 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
ES2618604T3 (en) 2010-11-05 2017-06-21 Pronova Biopharma Norge As Methods of treatment using lipid compounds
WO2014132134A1 (en) 2013-02-28 2014-09-04 Pronova Biopharma Norge As A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
CA3052449C (en) 2013-03-11 2021-10-19 Jan Remmereit Lipid compositions comprising 5, 11, 14-eicosatrienoic acid and conjugated linoleic acids
CA2904827C (en) 2013-03-11 2020-10-27 Life Science Nutrition As Natural lipids containing non-oxidizable fatty acids
AU2016256552B2 (en) 2015-04-28 2021-04-01 Pronova Biopharma Norge As Use of structurally enhanced fatty acids containing sulphur for preventing and/or treating non-alcoholic steatohepatitis
KR20200096791A (en) 2017-12-06 2020-08-13 바스프 에이에스 Fatty acid derivatives for the treatment of non-alcoholic steatohepatitis

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CN100351259C (en) 2002-06-20 2007-11-28 Icvec有限公司 Sulfur-containing phospholipid derivatives
MX2007000813A (en) * 2004-07-19 2007-06-05 Thia Medica As Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities.

Also Published As

Publication number Publication date
HK1050182A1 (en) 2003-06-13
ES2250360T3 (en) 2006-04-16
RU2288215C2 (en) 2006-11-27
JP2003527364A (en) 2003-09-16
US7902399B2 (en) 2011-03-08
WO2001068582A1 (en) 2001-09-20
AU2001237835B2 (en) 2006-03-23
KR20020077931A (en) 2002-10-14
KR20090108135A (en) 2009-10-14
KR100982228B1 (en) 2010-09-14
EP1265838B9 (en) 2006-05-10
CN1283611C (en) 2006-11-08
NZ521137A (en) 2004-08-27
NO20001123D0 (en) 2000-03-03
BR0108950A (en) 2003-01-28
US20040213442A1 (en) 2004-10-28
KR100857626B1 (en) 2008-09-08
DE60113663D1 (en) 2006-02-09
EP1265838A1 (en) 2002-12-18
CA2401757C (en) 2010-09-14
NO20001123L (en) 2001-09-04
CA2401757A1 (en) 2001-09-20
KR20080046747A (en) 2008-05-27
NO328803B1 (en) 2010-05-18
DK1265838T3 (en) 2006-02-20
MX236472B (en) 2006-05-04
JP5122050B2 (en) 2013-01-16
AU3783501A (en) 2001-09-24
KR100940373B1 (en) 2010-02-02
RU2002123590A (en) 2004-02-27
DE60113663T2 (en) 2006-07-27
MXPA02008629A (en) 2003-09-22
EP1265838B1 (en) 2005-09-28
CN1419532A (en) 2003-05-21

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