ATE305300T1 - Verwendung von cyclopamine, zur behandlung des basalzellkarzinoms und anderer tumoren - Google Patents
Verwendung von cyclopamine, zur behandlung des basalzellkarzinoms und anderer tumorenInfo
- Publication number
- ATE305300T1 ATE305300T1 AT01952097T AT01952097T ATE305300T1 AT E305300 T1 ATE305300 T1 AT E305300T1 AT 01952097 T AT01952097 T AT 01952097T AT 01952097 T AT01952097 T AT 01952097T AT E305300 T1 ATE305300 T1 AT E305300T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopamine
- tumors
- cell carcinoma
- basal cell
- tumor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/TR2001/000027 WO2002078703A1 (en) | 2001-07-02 | 2001-07-02 | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE305300T1 true ATE305300T1 (de) | 2005-10-15 |
Family
ID=21619326
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01952097T ATE305300T1 (de) | 2001-07-02 | 2001-07-02 | Verwendung von cyclopamine, zur behandlung des basalzellkarzinoms und anderer tumoren |
AT02736467T ATE299022T1 (de) | 2001-07-02 | 2002-04-19 | Verwendung von cyclopamine zur herstellung eines arzneimittels zur behandlung von psoriasis |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02736467T ATE299022T1 (de) | 2001-07-02 | 2002-04-19 | Verwendung von cyclopamine zur herstellung eines arzneimittels zur behandlung von psoriasis |
Country Status (14)
Country | Link |
---|---|
EP (4) | EP2216022B1 (de) |
JP (3) | JP2004536045A (de) |
KR (1) | KR20090125833A (de) |
CN (2) | CN1525859B (de) |
AT (2) | ATE305300T1 (de) |
AU (1) | AU2001272892B8 (de) |
BR (1) | BR0117063A (de) |
CA (1) | CA2452151C (de) |
DE (2) | DE60113733T2 (de) |
DK (2) | DK1401438T3 (de) |
ES (3) | ES2250434T3 (de) |
PT (1) | PT1411938E (de) |
RU (1) | RU2312661C2 (de) |
WO (2) | WO2002078703A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US20170326118A1 (en) | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
CA2452151C (en) * | 2001-07-02 | 2012-01-03 | Sinan Tas | Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis |
CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
US8653083B2 (en) | 2005-08-22 | 2014-02-18 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
PT2500360E (pt) | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
EP1998785A4 (de) * | 2006-02-21 | 2009-06-17 | Univ Michigan | Krebsbehandlung mithilfe eines hedgehog-signalisierungspfades |
EP2431388A1 (de) * | 2006-10-31 | 2012-03-21 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Geglättete Polypeptide und Verwendungsverfahren |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
US8148147B2 (en) | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
JP2010520295A (ja) | 2007-03-07 | 2010-06-10 | インフィニティ・ディスカバリー・インコーポレイテッド | へテロ環状シクロパミン類似体及びその使用方法 |
KR20090117956A (ko) * | 2007-03-07 | 2009-11-16 | 인피니티 디스커버리, 인코포레이티드 | 시클로파민 락탐 유사체 및 그의 사용 방법 |
EP2224807B1 (de) | 2007-12-27 | 2016-11-09 | Infinity Pharmaceuticals, Inc. | Verfahren für stereoselektive reduktion |
WO2009099625A2 (en) * | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
JP2009143963A (ja) * | 2009-03-25 | 2009-07-02 | Sinan Tas | 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ/スムーズンド信号を使用する腫瘍を治療するための製薬組成物 |
ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
JP2013530929A (ja) | 2010-04-01 | 2013-08-01 | オンコメッド ファーマシューティカルズ インコーポレイテッド | frizzled結合剤およびその使用 |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CA2887711A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
US9359444B2 (en) | 2013-02-04 | 2016-06-07 | Oncomed Pharmaceuticals Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2015096654A1 (zh) * | 2013-12-26 | 2015-07-02 | 中国科学院上海生命科学研究院 | Shh信号通路特异性抑制剂的应用 |
WO2016196928A1 (en) | 2015-06-04 | 2016-12-08 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
US20170231968A1 (en) * | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
CN117940170A (zh) | 2021-09-13 | 2024-04-26 | 辛南·塔斯 | 有效干预人类衰老和衰老疾病及其效果 |
CN114292279B (zh) * | 2022-01-07 | 2023-05-09 | 吉林省农业科学院 | 一种藜芦抗癌有效成分环杷明提取与分离方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7098196B1 (en) * | 1999-10-13 | 2006-08-29 | Johns Hopkins University School Of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
CA2326654C (en) * | 1998-04-09 | 2010-11-09 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
ES2233383T3 (es) * | 1999-06-08 | 2005-06-16 | Lorantis Limited | Utilizacion terapeutica de un ihibidor de la via de señalizacion hedgehog. |
EP1646395B8 (de) * | 1999-11-30 | 2014-12-17 | Curis, Inc. | Verfahren und zusammensetzungen zur regulierung der lymphozytenaktivität |
CU23175A1 (es) * | 2000-07-17 | 2006-09-22 | Ct De Investigacion Y Desarrol | Formulacion liposomica de propionato de clobetasol |
CA2452151C (en) * | 2001-07-02 | 2012-01-03 | Sinan Tas | Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis |
CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
-
2001
- 2001-07-02 CA CA2452151A patent/CA2452151C/en not_active Expired - Fee Related
- 2001-07-02 ES ES01952097T patent/ES2250434T3/es not_active Expired - Lifetime
- 2001-07-02 JP JP2002576969A patent/JP2004536045A/ja active Pending
- 2001-07-02 EP EP10163813.8A patent/EP2216022B1/de not_active Expired - Lifetime
- 2001-07-02 CN CN018234429A patent/CN1525859B/zh not_active Expired - Fee Related
- 2001-07-02 AT AT01952097T patent/ATE305300T1/de not_active IP Right Cessation
- 2001-07-02 ES ES10163813.8T patent/ES2534400T3/es not_active Expired - Lifetime
- 2001-07-02 WO PCT/TR2001/000027 patent/WO2002078703A1/en active IP Right Grant
- 2001-07-02 DK DK01952097T patent/DK1401438T3/da active
- 2001-07-02 DE DE60113733T patent/DE60113733T2/de not_active Expired - Lifetime
- 2001-07-02 BR BR0117063-5A patent/BR0117063A/pt active Search and Examination
- 2001-07-02 EP EP20140196071 patent/EP2862570A1/de not_active Withdrawn
- 2001-07-02 EP EP05008758A patent/EP1561464A3/de not_active Withdrawn
- 2001-07-02 AU AU2001272892A patent/AU2001272892B8/en not_active Ceased
- 2001-07-02 EP EP01952097A patent/EP1401438B1/de not_active Revoked
-
2002
- 2002-04-19 PT PT02736467T patent/PT1411938E/pt unknown
- 2002-04-19 WO PCT/TR2002/000017 patent/WO2002078704A1/en not_active Application Discontinuation
- 2002-04-19 DK DK02736467T patent/DK1411938T3/da active
- 2002-04-19 ES ES02736467T patent/ES2246011T3/es not_active Expired - Lifetime
- 2002-04-19 CN CNB02813429XA patent/CN1230169C/zh not_active Expired - Fee Related
- 2002-04-19 DE DE60204966T patent/DE60204966T2/de not_active Expired - Lifetime
- 2002-04-19 AT AT02736467T patent/ATE299022T1/de not_active IP Right Cessation
- 2002-04-19 RU RU2004103074/15A patent/RU2312661C2/ru not_active IP Right Cessation
-
2003
- 2003-03-17 KR KR1020097022024A patent/KR20090125833A/ko active Search and Examination
-
2010
- 2010-02-10 JP JP2010028010A patent/JP5424923B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-18 JP JP2013193304A patent/JP2014028834A/ja not_active Ceased
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Legal Events
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UEP | Publication of translation of european patent specification |
Ref document number: 1401438 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |