ATE297205T1 - Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus - Google Patents

Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus

Info

Publication number
ATE297205T1
ATE297205T1 AT01118037T AT01118037T ATE297205T1 AT E297205 T1 ATE297205 T1 AT E297205T1 AT 01118037 T AT01118037 T AT 01118037T AT 01118037 T AT01118037 T AT 01118037T AT E297205 T1 ATE297205 T1 AT E297205T1
Authority
AT
Austria
Prior art keywords
penem
absorption
antibacterial composition
improving
gastrointestinal tract
Prior art date
Application number
AT01118037T
Other languages
English (en)
Inventor
Osamu Sugita
Yasushi Kanai
Takumi Kojima
Original Assignee
Daiichi Suntory Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP03147691A external-priority patent/JP3148263B2/ja
Priority claimed from JP03147891A external-priority patent/JP3161741B2/ja
Priority claimed from JP3147591A external-priority patent/JP3377219B2/ja
Priority claimed from JP3147791A external-priority patent/JP3178726B2/ja
Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd
Application granted granted Critical
Publication of ATE297205T1 publication Critical patent/ATE297205T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01118037T 1991-02-01 1992-01-30 Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus ATE297205T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP03147691A JP3148263B2 (ja) 1991-02-01 1991-02-01 抗菌性組成物
JP03147891A JP3161741B2 (ja) 1991-02-01 1991-02-01 ペネム類の消化管吸収改善剤および改善方法
JP3147591A JP3377219B2 (ja) 1991-02-01 1991-02-01 経口抗菌組成物
JP3147791A JP3178726B2 (ja) 1991-02-01 1991-02-01 抗菌剤組成物

Publications (1)

Publication Number Publication Date
ATE297205T1 true ATE297205T1 (de) 2005-06-15

Family

ID=27459440

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01118037T ATE297205T1 (de) 1991-02-01 1992-01-30 Orale antibakterielle zusammensetzung und verfahren zur verbesserung der resorption von penem oder carbapenem antibiotika im magen-darm- traktus
AT92101563T ATE217195T1 (de) 1991-02-01 1992-01-30 Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92101563T ATE217195T1 (de) 1991-02-01 1992-01-30 Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt

Country Status (5)

Country Link
US (2) US5354748A (de)
EP (2) EP0497353B1 (de)
AT (2) ATE297205T1 (de)
DE (2) DE69232598T2 (de)
ES (2) ES2244529T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE448782T1 (de) 1996-12-31 2009-12-15 Antioxidant Pharmaceuticals Co Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
US6365635B1 (en) * 1998-01-13 2002-04-02 Suntory Limited Antibacterial composition for topical administration containing antibiotic
JP4745573B2 (ja) * 1999-09-17 2011-08-10 マルホ株式会社 抗菌医薬組成物
US20040202714A1 (en) * 1999-10-12 2004-10-14 Daiichi Suntory Pharma Co., Ltd. Oral pharmaceutical composition
US8148356B2 (en) 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
US20140171357A1 (en) * 2011-03-24 2014-06-19 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
CN103371977A (zh) * 2012-04-25 2013-10-30 秦引林 一种泰比培南酯颗粒及其制备方法
EP2956153A4 (de) * 2013-02-15 2017-03-22 Your Energy Systems, LLC Behandlung von klebsiella-pneumoniae-vermittelten krankheiten mit sich entwickelnder antibakterieller resistenz mithilfe von liposomal formuliertem glutathion

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668504A (en) * 1970-11-18 1987-05-26 Merck & Co., Inc. Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
AR244550A1 (es) * 1978-07-24 1993-11-30 Merck & Co Inc Procedimiento para obtener una composicion de antibioticos del tipo de la tienamicina con inhibidores de la dipeptidasa
PH16708A (en) * 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4616038A (en) * 1978-07-24 1986-10-07 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4539208A (en) * 1980-09-17 1985-09-03 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4378314A (en) * 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
IE50333B1 (en) * 1979-11-02 1986-04-02 Merck & Co Inc Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4406902A (en) * 1980-09-17 1983-09-27 Merck & Co., Inc. Dipeptidase inhibitors
PT73640B (en) * 1980-09-17 1983-10-19 Merck & Co Inc Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase
NZ201471A (en) * 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
US4739113A (en) * 1986-05-30 1988-04-19 Merck & Co., Inc. Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors
US5061730A (en) * 1987-01-26 1991-10-29 Fujisawa Pharmaceutical Co., Ltd. Carboxylic acid derivatives
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
DE69019610D1 (de) * 1989-07-06 1995-06-29 Banyu Pharma Co Ltd Cyclische Derivate des Amidinylthiocarbapenems.
CA2022382A1 (en) * 1989-08-02 1991-02-03 Susumu Nakagawa Piperidylthiocarbapenem derivatives

Also Published As

Publication number Publication date
DE69232598D1 (de) 2002-06-13
ATE217195T1 (de) 2002-05-15
ES2244529T3 (es) 2005-12-16
ES2176179T3 (es) 2002-12-01
EP0497353A2 (de) 1992-08-05
DE69233529D1 (de) 2005-07-14
DE69232598T2 (de) 2002-11-21
US5637612A (en) 1997-06-10
DE69233529T2 (de) 2005-11-24
EP1161947B1 (de) 2005-06-08
EP1161947A3 (de) 2002-07-03
EP0497353A3 (en) 1992-12-02
EP0497353B1 (de) 2002-05-08
US5354748A (en) 1994-10-11
EP1161947A2 (de) 2001-12-12

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties