ATE295360T1 - Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents

Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten

Info

Publication number
ATE295360T1
ATE295360T1 AT97947865T AT97947865T ATE295360T1 AT E295360 T1 ATE295360 T1 AT E295360T1 AT 97947865 T AT97947865 T AT 97947865T AT 97947865 T AT97947865 T AT 97947865T AT E295360 T1 ATE295360 T1 AT E295360T1
Authority
AT
Austria
Prior art keywords
benzenecarbonic
acid amide
amide derivatives
condensed heterocyclic
containing same
Prior art date
Application number
AT97947865T
Other languages
English (en)
Inventor
Tsunetoshi Honma
Yoshiharu Hiramatsu
Akinori Arimura
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE295360T1 publication Critical patent/ATE295360T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
AT97947865T 1996-12-12 1997-12-10 Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten ATE295360T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33196296 1996-12-12
PCT/JP1997/004526 WO1998025915A1 (fr) 1996-12-12 1997-12-10 Derives d'amide d'acide benzenecarboxylique condenses heterocycliques et antagonistes pgd2 renfermant ces derives

Publications (1)

Publication Number Publication Date
ATE295360T1 true ATE295360T1 (de) 2005-05-15

Family

ID=18249599

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947865T ATE295360T1 (de) 1996-12-12 1997-12-10 Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten

Country Status (7)

Country Link
US (1) US6069166A (de)
EP (1) EP0945450B1 (de)
JP (1) JP4120993B2 (de)
AT (1) ATE295360T1 (de)
AU (1) AU5409698A (de)
DE (1) DE69733271T2 (de)
WO (1) WO1998025915A1 (de)

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US6958772B1 (en) 1999-01-20 2005-10-25 Canon Kabushiki Kaisha Image sensing apparatus and image processing method therefor
CN1179945C (zh) 2000-03-09 2004-12-15 小野药品工业株式会社 吲哚衍生物、其制备方法及用途
JPWO2002036583A1 (ja) * 2000-11-01 2004-03-11 塩野義製薬株式会社 Ｐｇｄ２受容体拮抗性医薬組成物
JP4145654B2 (ja) * 2001-01-26 2008-09-03 塩野義製薬株式会社 トロンボポエチン受容体アゴニスト作用を有する環状化合物
US7534897B2 (en) 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
US6927183B1 (en) * 2002-09-04 2005-08-09 Diversitech Corporation Reinforced article
CN1930162B (zh) 2004-03-11 2010-06-16 埃科特莱茵药品有限公司 四氢吡啶并吲哚衍生物
EP1804786A4 (de) * 2004-09-29 2008-01-02 Cytovia Inc Substituierte n-aryl-9-oxo-9h-fluorene-1-carboxamide und analoga als aktivatoren von caspasen und apoptose-auslösern
AR079492A1 (es) 2009-12-23 2012-02-01 Ironwood Pharmaceuticals Inc Moduladores de crth2
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2012003405A1 (en) 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2012009137A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009134A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
NZ609955A (en) 2010-11-09 2015-05-29 Ironwood Pharmaceuticals Inc Sgc stimulators
EP2797915B1 (de) 2011-12-27 2016-07-13 Ironwood Pharmaceuticals, Inc. 2-Benzyl-3-(Oxazol/Thiazol)-5-(Pyrimidin-2-yl)-1(H)-Pyrazol-Derivate als Stimulatoren der löslichen Guanylat-Cyclase (sGC) zur Behandlung von Bluthochdruck und Herzversagen
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2897953B8 (de) 2012-09-19 2019-06-26 Cyclerion Therapeutics, Inc. Sgc-stimulatoren
SI3660013T1 (sl) 2013-03-15 2022-05-31 Cyclerion Therapeutics, Inc. SGC stimulatorji
EP3092231B1 (de) 2013-12-11 2018-06-27 Ironwood Pharmaceuticals, Inc. Sgc-stimulatoren
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
EP3194382B1 (de) 2014-09-17 2021-09-08 Cyclerion Therapeutics, Inc. Pyrazolderivate als sgc-stimulatoren
JP2017527604A (ja) 2014-09-17 2017-09-21 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激剤
EP3481820B1 (de) 2016-07-07 2023-10-18 Cyclerion Therapeutics, Inc. Feste formen eines sgc-stimulators
AU2017291826B2 (en) 2016-07-07 2021-10-21 Cyclerion Therapeutics, Inc. Phosphorus prodrugs of sGC stimulators

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Publication number Priority date Publication date Assignee Title
EP0044711B1 (de) * 1980-07-22 1984-03-14 Ono Pharmaceutical Co., Ltd. Analoge von 9,11-Methano-13-aza-11a-carbathromban-Säure und deren pharmazeutische Verwendung
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
JPH0623170B2 (ja) * 1987-05-08 1994-03-30 塩野義製薬株式会社 ビシクロ環系スルホンアミド誘導体およびその製造法
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
EP0312906A3 (de) * 1987-10-23 1990-09-05 Ono Pharmaceutical Co., Ltd. Sulfonamidderivate
TW234123B (de) * 1992-12-16 1994-11-11 Takeda Pharm Industry Co Ltd
KR100428601B1 (ko) * 1995-06-21 2004-09-16 시오노기세이야쿠가부시키가이샤 비사이클릭아미노유도체및이들을함유하는프로스타글란딘디2길항제
US5763609A (en) * 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives

Also Published As

Publication number Publication date
EP0945450A4 (de) 2001-12-12
EP0945450A1 (de) 1999-09-29
EP0945450B1 (de) 2005-05-11
DE69733271T2 (de) 2006-01-26
AU5409698A (en) 1998-07-03
JP4120993B2 (ja) 2008-07-16
DE69733271D1 (de) 2005-06-16
US6069166A (en) 2000-05-30
WO1998025915A1 (fr) 1998-06-18

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