ATE290103T1 - Verfahren zur herstellung eines biochip sowie biochip - Google Patents

Verfahren zur herstellung eines biochip sowie biochip

Info

Publication number
ATE290103T1
ATE290103T1 AT99958329T AT99958329T ATE290103T1 AT E290103 T1 ATE290103 T1 AT E290103T1 AT 99958329 T AT99958329 T AT 99958329T AT 99958329 T AT99958329 T AT 99958329T AT E290103 T1 ATE290103 T1 AT E290103T1
Authority
AT
Austria
Prior art keywords
biochip
pyrrole
functionalised
microtroughs
electropolymerisation
Prior art date
Application number
AT99958329T
Other languages
English (en)
Inventor
Charles Rosilio
Patrice Caillat
Original Assignee
Commissariat Energie Atomique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique filed Critical Commissariat Energie Atomique
Application granted granted Critical
Publication of ATE290103T1 publication Critical patent/ATE290103T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
AT99958329T 1998-12-16 1999-12-15 Verfahren zur herstellung eines biochip sowie biochip ATE290103T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9815883A FR2787582B1 (fr) 1998-12-16 1998-12-16 Procede de fabrication d'une biopuce et biopuce
PCT/FR1999/003141 WO2000036145A1 (fr) 1998-12-16 1999-12-15 Procede de fabrication d'une biopuce et biopuce

Publications (1)

Publication Number Publication Date
ATE290103T1 true ATE290103T1 (de) 2005-03-15

Family

ID=9534034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99958329T ATE290103T1 (de) 1998-12-16 1999-12-15 Verfahren zur herstellung eines biochip sowie biochip

Country Status (7)

Country Link
US (1) US6803228B1 (de)
EP (1) EP1141391B1 (de)
JP (1) JP2002532699A (de)
AT (1) ATE290103T1 (de)
DE (1) DE69924010T2 (de)
FR (1) FR2787582B1 (de)
WO (1) WO2000036145A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2789401B1 (fr) * 1999-02-08 2003-04-04 Cis Bio Int Procede de fabrication de matrices de ligands adresses sur un support
US7407746B2 (en) * 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
FR2821575B1 (fr) * 2001-03-02 2003-10-24 Commissariat Energie Atomique Procede de greffage organique localise sans masque sur des protions conductrices ou semiconductrices de surfaces composites
FR2823999B1 (fr) * 2001-04-27 2003-06-27 Commissariat Energie Atomique Dispositif miniature de separation et d'isolement d'objets biologiques et utilisations
FR2824143B1 (fr) * 2001-04-27 2003-06-27 Commissariat Energie Atomique Utilisations d'un dispositif miniature de separation et d'isolement d'objets biologiques et procedes mis en oeuvre
FR2831275B1 (fr) * 2001-10-18 2004-01-30 Commissariat Energie Atomique Substrat revetu d'un film organique transparent et procede de fabrication
US6908678B2 (en) 2002-01-18 2005-06-21 Advanced Gene Technology, Corp. Plastic slides for the fabrication of biochips
FR2847581B1 (fr) * 2002-11-21 2007-03-23 Commissariat Energie Atomique Procede de fixation d'une proteine sur un polymere a base de pyrrole et son utilisation pour la fabrication d'un capteur
FR2849038B1 (fr) * 2002-12-19 2005-03-11 Apibio Nouveaux pyrroles substitues avec des oligonucleotides, polymeres electroactifs et leurs utilisations
DE10305957A1 (de) * 2003-02-12 2005-02-03 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Elektrisch leitfähiger Kunststoff-Formkörper
FR2861609B1 (fr) 2003-10-31 2006-02-03 Commissariat Energie Atomique Procede de repartition de gouttes d'un liquide d'interet sur une surface
US20060121501A1 (en) * 2004-10-22 2006-06-08 Stanislaw Burzynski Method for immobilizing molecular probes to a semiconductor oxide surface
EP1939621B1 (de) * 2005-09-16 2014-11-19 Azbil Corporation Verfahren zur herstellung des biochipsubstrats und verfahren zur herstellung des biochips
JP4755871B2 (ja) * 2005-09-16 2011-08-24 株式会社山武 バイオチップ用基板及びバイオチップの製造方法
JP4763402B2 (ja) * 2005-09-26 2011-08-31 株式会社山武 バイオチップの製造方法及びバイオチップ用基板
FR2903590B1 (fr) * 2006-07-13 2013-05-10 Commissariat Energie Atomique Dispositif de prelevement cellulaire par contact
FR2927169B1 (fr) * 2008-02-05 2013-01-11 Commissariat Energie Atomique Procede de fonctionnalisation de la surface d'un pore
US9079999B2 (en) * 2008-02-26 2015-07-14 Rigoberto Advincula Methods for preparing polymer coatings by electrochemical grafting of polymer brushes, compositions prepared thereby and compositions for preparing the coatings
FR2959568A1 (fr) 2010-04-28 2011-11-04 Commissariat Energie Atomique Procede et dispositif pour detecter et quantifier un analyte avec recyclage des reactifs
JP5704995B2 (ja) * 2011-03-31 2015-04-22 一般財団法人電力中央研究所 修飾電極、並びに、フローセル、測定装置、及び測定方法
CN103616426B (zh) * 2013-12-02 2016-05-11 中国科学院上海应用物理研究所 一种用于快速生化分析的集成式的微流控电化学生物传感***及其使用方法
JP6714278B2 (ja) * 2014-09-19 2020-06-24 国立大学法人 新潟大学 基質抗原同時検出バイオセンサ、基質抗原同時検出方法、および、プログラム
GB2561173A (en) * 2017-04-03 2018-10-10 Univ Dublin City Microfluidic device for detection of analytes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480314A1 (fr) * 1980-04-11 1981-10-16 Commissariat Energie Atomique Procede de depot par electropolymerisation de films minces organiques sur des surfaces conductrices de l'electricite en particulier sur des surfaces metalliques, et films minces ainsi obtenus
CA1311715C (en) * 1985-12-20 1992-12-22 Stanley J. Jasne Method for the electropolymerization of conductive polymers
EP0402554B1 (de) * 1989-06-12 1993-11-18 Honda Giken Kogyo Kabushiki Kaisha Verfahren zur Stabilisierung von elektroaktiven Polymerelektroden
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
FR2696043B1 (fr) * 1992-09-18 1994-10-14 Commissariat Energie Atomique Support à réseau d'éléments résistifs en polymère conducteur et son procédé de fabrication.
FR2703359B1 (fr) * 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
FR2714077B1 (fr) * 1993-12-21 1996-03-08 Lorraine Laminage Procédé et bain de dépôt électrolytique de polypyrrole sur une surface de métal oxydable par électropolymérisation.
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US5810989A (en) * 1997-09-04 1998-09-22 Motorola, Inc. Photoelectric synthesis of DNA or protein probe arrays
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
US6312896B1 (en) * 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities

Also Published As

Publication number Publication date
DE69924010T2 (de) 2006-04-13
FR2787582B1 (fr) 2001-01-12
US6803228B1 (en) 2004-10-12
EP1141391B1 (de) 2005-03-02
WO2000036145A1 (fr) 2000-06-22
FR2787582A1 (fr) 2000-06-23
JP2002532699A (ja) 2002-10-02
DE69924010D1 (de) 2005-04-07
EP1141391A1 (de) 2001-10-10

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