ATE284893T1 - Kristallisation von doxorubicin-hydrochlorid - Google Patents

Kristallisation von doxorubicin-hydrochlorid

Info

Publication number
ATE284893T1
ATE284893T1 AT99947917T AT99947917T ATE284893T1 AT E284893 T1 ATE284893 T1 AT E284893T1 AT 99947917 T AT99947917 T AT 99947917T AT 99947917 T AT99947917 T AT 99947917T AT E284893 T1 ATE284893 T1 AT E284893T1
Authority
AT
Austria
Prior art keywords
doxorubicin hydrochloride
crystallization
doxorubicin
carrying
condition
Prior art date
Application number
AT99947917T
Other languages
English (en)
Inventor
Osamu Johdo
Takuma Nakao
Takeo Yoshioka
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Application granted granted Critical
Publication of ATE284893T1 publication Critical patent/ATE284893T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99947917T 1998-10-16 1999-10-15 Kristallisation von doxorubicin-hydrochlorid ATE284893T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30954298 1998-10-16
PCT/JP1999/005699 WO2000023453A1 (fr) 1998-10-16 1999-10-15 Cristallisation de chlorhydrate de doxorubicine

Publications (1)

Publication Number Publication Date
ATE284893T1 true ATE284893T1 (de) 2005-01-15

Family

ID=17994281

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99947917T ATE284893T1 (de) 1998-10-16 1999-10-15 Kristallisation von doxorubicin-hydrochlorid

Country Status (11)

Country Link
US (1) US6653455B1 (de)
EP (1) EP1122260B1 (de)
JP (1) JP4533537B2 (de)
CN (1) CN1188424C (de)
AT (1) ATE284893T1 (de)
AU (1) AU750738B2 (de)
CA (1) CA2347515C (de)
DE (1) DE69922681T2 (de)
ES (1) ES2235518T3 (de)
NZ (1) NZ511093A (de)
WO (1) WO2000023453A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
ES2554527T3 (es) * 2006-01-24 2015-12-21 Biocompatibles Uk Limited Proceso para rellenar partículas poliméricas con un fármaco
US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP3222628A1 (de) 2008-12-23 2017-09-27 Gilead Pharmasset LLC Nukleosid-phosphoramidate
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
EP2636676A3 (de) * 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Kristallisierung von Epidaunorubicin x HCI
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
UY33312A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidato de nucleosido de purina
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1457632A (en) 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
IT1155446B (it) * 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
HU204570B (en) * 1989-09-04 1992-01-28 Gyogyszerkutato Intezet Process for purifying adriamycin-hydrochloride
JP3980101B2 (ja) * 1996-11-25 2007-09-26 財団法人微生物化学研究会 結晶質アントラサイクリン抗生物質およびその製造方法
JP2975018B2 (ja) * 1997-11-28 1999-11-10 住友製薬株式会社 結晶性塩酸アムルビシン

Also Published As

Publication number Publication date
CA2347515C (en) 2009-10-13
JP4533537B2 (ja) 2010-09-01
EP1122260B1 (de) 2004-12-15
CA2347515A1 (en) 2000-04-27
EP1122260A4 (de) 2001-12-19
NZ511093A (en) 2003-04-29
CN1188424C (zh) 2005-02-09
EP1122260A1 (de) 2001-08-08
CN1323312A (zh) 2001-11-21
US6653455B1 (en) 2003-11-25
DE69922681D1 (de) 2005-01-20
DE69922681T2 (de) 2005-05-25
WO2000023453A1 (fr) 2000-04-27
AU750738B2 (en) 2002-07-25
ES2235518T3 (es) 2005-07-01
AU6123499A (en) 2000-05-08

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