ATE283700T1 - Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges - Google Patents
Therapeutische verwendung eines inhibitors des hedgehog signalübertragungswegesInfo
- Publication number
- ATE283700T1 ATE283700T1 AT00935413T AT00935413T ATE283700T1 AT E283700 T1 ATE283700 T1 AT E283700T1 AT 00935413 T AT00935413 T AT 00935413T AT 00935413 T AT00935413 T AT 00935413T AT E283700 T1 ATE283700 T1 AT E283700T1
- Authority
- AT
- Austria
- Prior art keywords
- signal transmission
- therapeutic use
- pathway inhibitor
- transmission pathway
- hedgehog signal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9913350.6A GB9913350D0 (en) | 1999-06-08 | 1999-06-08 | Therapeutic use |
GBGB9921953.7A GB9921953D0 (en) | 1999-09-16 | 1999-09-16 | Therapeutic use |
PCT/GB2000/002191 WO2000074706A1 (en) | 1999-06-08 | 2000-06-05 | Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE283700T1 true ATE283700T1 (de) | 2004-12-15 |
Family
ID=26315650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00935413T ATE283700T1 (de) | 1999-06-08 | 2000-06-05 | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
Country Status (10)
Country | Link |
---|---|
US (1) | US20020192216A1 (de) |
EP (1) | EP1183040B1 (de) |
JP (1) | JP2003501395A (de) |
AT (1) | ATE283700T1 (de) |
AU (1) | AU780358B2 (de) |
CA (1) | CA2376210A1 (de) |
DE (1) | DE60016402T2 (de) |
ES (1) | ES2233383T3 (de) |
GB (1) | GB0013674D0 (de) |
WO (1) | WO2000074706A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998035020A2 (en) | 1997-02-10 | 1998-08-13 | The Presidents And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
ATE328002T1 (de) | 1999-10-13 | 2006-06-15 | Univ Johns Hopkins Med | Verbindungen zur regulierung des hedgehog- signalwegs, zusammensetzungen und verwendungen davon |
CA2388468C (en) * | 1999-10-14 | 2011-01-25 | Curis, Inc. | Mediators of hedgehog signalling pathways, compositions and uses related thereto |
US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US8168178B2 (en) | 1999-11-30 | 2012-05-01 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
US6951839B1 (en) | 1999-11-30 | 2005-10-04 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
CA2392958A1 (en) * | 1999-11-30 | 2001-06-07 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
US20030022819A1 (en) * | 2000-06-16 | 2003-01-30 | Ling Leona E. | Angiogenesis-modulating compositions and uses |
WO2002030462A2 (en) | 2000-10-13 | 2002-04-18 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
AU2002247847A1 (en) * | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
EP2216022B1 (de) * | 2001-07-02 | 2015-01-07 | Sinan Tas | Verwendung des Cyclopamins zur Behandlung des basalen Zellkarzinoms und anderer Tumore |
CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
US20040247593A1 (en) * | 2002-10-04 | 2004-12-09 | Regents Of The University Of California, | Methods for treating cancer by inhibiting Wnt signaling |
FR2850022B1 (fr) * | 2003-01-22 | 2006-09-08 | Centre Nat Rech Scient | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
JP2007507429A (ja) * | 2003-10-06 | 2007-03-29 | モナシュ ユニバーシティー | 治療方法 |
DK1730280T3 (en) | 2004-03-26 | 2019-02-04 | Curis Inc | RNA interference modulators for hedgehog signaling and applications thereof |
CN1981054A (zh) * | 2004-05-14 | 2007-06-13 | 加利福尼亚大学董事会 | 用抗wnt2单克隆抗体和sirna治疗癌症的方法 |
CA2567330A1 (en) | 2004-05-21 | 2005-12-01 | The Regents Of The University Of California | Methods for treating and diagnosing cancer with wnt inhibitory factor-1 (wif-1) |
US8257438B2 (en) | 2005-04-12 | 2012-09-04 | Warsaw Orthopedic, Inc. | Methods and devices for preserving motion in an articulating prosthetic disc |
WO2007033063A2 (en) * | 2005-09-12 | 2007-03-22 | The Board Of Regents Of The University Of Texas System | Regulation of the hedgehog signaling pathway and uses thereof |
GB0610242D0 (en) * | 2006-05-23 | 2006-07-05 | Novartis Ag | Organic compounds |
WO2008039200A1 (en) * | 2006-09-27 | 2008-04-03 | Irm Llc | Methods and compositions for treating lymphoma and myeloma |
DK2137162T3 (en) * | 2007-03-15 | 2018-11-26 | Novartis Ag | Organic compounds and their applications |
GB0707349D0 (en) * | 2007-04-17 | 2007-05-23 | Renovo Ltd | Medicaments and methods for accelerating wound healing |
US8530456B2 (en) | 2008-04-21 | 2013-09-10 | President And Fellows Of Harvard College | Sonic hedgehog modulators |
BRPI0911618A2 (pt) | 2008-04-29 | 2019-09-24 | Lilly Co Eli | antagonistas da via hedgehog de ftalazina dissubstituída. |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
EP2177208A1 (de) * | 2008-10-17 | 2010-04-21 | Ferrer Internacional, S.A. | Pharmazeutische topische Zusammensetzungen |
EA018931B1 (ru) | 2008-11-03 | 2013-11-29 | Эли Лилли Энд Компани | ДИЗАМЕЩЕННЫЕ ФТАЛАЗИНЫ-АНТАГОНИСТЫ СИГНАЛЬНОГО ПУТИ Hedgehog |
KR101335770B1 (ko) | 2008-11-17 | 2013-12-12 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
CN102216285B (zh) | 2008-11-17 | 2014-08-13 | 伊莱利利公司 | 四取代的哒嗪hedgehog途径拮抗剂 |
AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
DE102010052941A1 (de) * | 2010-11-18 | 2012-05-24 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Therapeutisches Protein |
US20140303068A1 (en) * | 2011-10-28 | 2014-10-09 | Paranta Biosciences Limited | Method of treating mucus hypersecretion |
GB201204201D0 (en) * | 2012-03-09 | 2012-04-25 | Ucl Business Plc | Erythropoiesis |
GB201204645D0 (en) * | 2012-03-16 | 2012-05-02 | Ucl Business Plc | Treatment of disease |
SG11201502137YA (en) * | 2012-09-21 | 2015-04-29 | Agency Science Tech & Res | A method for treating a disease or disorder of the lung by inhibition of the hedgehog pathway |
JP5804389B2 (ja) * | 2013-01-11 | 2015-11-04 | 国立大学法人東北大学 | 運動に応答して筋肉細胞において発現変動するタンパク質及びそれらの受容体、それらをコードする遺伝子、並びにそれらを用いたスクリーニング方法 |
WO2014113191A1 (en) | 2013-01-15 | 2014-07-24 | Xiaohu Zhang | Hedgehog pathway signaling inhibitors and therapeutic applications thereof |
KR102262275B1 (ko) | 2016-07-04 | 2021-06-08 | 수조우 킨터 제약회사(주) | 헤지호그 경로 길항제 활성을 갖는 키랄 헤테로사이클릭 화합물, 이의 방법 및 용도 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989011862A1 (en) * | 1988-05-31 | 1989-12-14 | Biotechnology Australia Pty. Ltd. | Actions of hormones |
WO1998012326A1 (en) * | 1996-09-20 | 1998-03-26 | President And Fellows Of Harvard College | Hedgehog interacting proteins and uses related thereto |
US5989909A (en) * | 1997-09-26 | 1999-11-23 | Millennium Biotherapeutics, Inc. | Huchordin and uses thereof |
JPH114695A (ja) * | 1997-04-25 | 1999-01-12 | Hayashibara Biochem Lab Inc | ヘッジホッグ蛋白質 |
US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
US6432970B2 (en) * | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
AU768130B2 (en) * | 1998-04-09 | 2003-12-04 | Johns Hopkins University School Of Medicine, The | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
AU4416499A (en) * | 1998-06-03 | 1999-12-20 | President And Fellows Of Harvard College, The | Use of bigenic mouse models and assay systems to identify agents that regulate proliferation and differentiation |
EP1112087B1 (de) * | 1998-09-11 | 2010-02-24 | Curis, Inc. | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
WO2000015246A2 (en) * | 1998-09-11 | 2000-03-23 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
AU765485B2 (en) * | 1998-11-02 | 2003-09-18 | Curis, Inc. | Functional antagonists of hedgehog activity |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
IL145898A0 (en) * | 1999-04-22 | 2002-07-25 | Biogen Inc | Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit |
US6743613B2 (en) * | 1999-04-23 | 2004-06-01 | Human Genome Sciences, Inc. | Lysyl-oxidase HOHEC84 polynucleotides |
-
2000
- 2000-06-05 GB GBGB0013674.7A patent/GB0013674D0/en not_active Ceased
- 2000-06-05 CA CA002376210A patent/CA2376210A1/en not_active Abandoned
- 2000-06-05 ES ES00935413T patent/ES2233383T3/es not_active Expired - Lifetime
- 2000-06-05 AU AU50955/00A patent/AU780358B2/en not_active Ceased
- 2000-06-05 DE DE60016402T patent/DE60016402T2/de not_active Revoked
- 2000-06-05 EP EP00935413A patent/EP1183040B1/de not_active Revoked
- 2000-06-05 WO PCT/GB2000/002191 patent/WO2000074706A1/en active Search and Examination
- 2000-06-05 AT AT00935413T patent/ATE283700T1/de not_active IP Right Cessation
- 2000-06-05 JP JP2001501240A patent/JP2003501395A/ja active Pending
-
2001
- 2001-12-07 US US10/013,310 patent/US20020192216A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60016402T2 (de) | 2005-10-27 |
AU780358B2 (en) | 2005-03-17 |
JP2003501395A (ja) | 2003-01-14 |
EP1183040A1 (de) | 2002-03-06 |
GB0013674D0 (en) | 2000-07-26 |
ES2233383T3 (es) | 2005-06-16 |
EP1183040B1 (de) | 2004-12-01 |
US20020192216A1 (en) | 2002-12-19 |
AU5095500A (en) | 2000-12-28 |
DE60016402D1 (de) | 2005-01-05 |
WO2000074706A1 (en) | 2000-12-14 |
CA2376210A1 (en) | 2000-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |