ATE278679T1 - Zwischenprodukte in der synthese von epothilonen und verfahren zu deren herstellung - Google Patents

Zwischenprodukte in der synthese von epothilonen und verfahren zu deren herstellung

Info

Publication number
ATE278679T1
ATE278679T1 AT99952092T AT99952092T ATE278679T1 AT E278679 T1 ATE278679 T1 AT E278679T1 AT 99952092 T AT99952092 T AT 99952092T AT 99952092 T AT99952092 T AT 99952092T AT E278679 T1 ATE278679 T1 AT E278679T1
Authority
AT
Austria
Prior art keywords
synthesis
epothilones
production
intermediate products
desoxyepothione
Prior art date
Application number
AT99952092T
Other languages
English (en)
Inventor
Karl-Heinz Altmann
Armin Bauer
Dieter Schinzer
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE278679T1 publication Critical patent/ATE278679T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99952092T 1998-05-18 1999-05-14 Zwischenprodukte in der synthese von epothilonen und verfahren zu deren herstellung ATE278679T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810659.4A GB9810659D0 (en) 1998-05-18 1998-05-18 Organic compounds
PCT/EP1999/003354 WO1999059985A1 (en) 1998-05-18 1999-05-14 Intermediates for the synthesis of epothilones and methods for their preparation

Publications (1)

Publication Number Publication Date
ATE278679T1 true ATE278679T1 (de) 2004-10-15

Family

ID=10832262

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99952092T ATE278679T1 (de) 1998-05-18 1999-05-14 Zwischenprodukte in der synthese von epothilonen und verfahren zu deren herstellung

Country Status (9)

Country Link
US (1) US6350878B1 (de)
EP (1) EP1080082B1 (de)
AT (1) ATE278679T1 (de)
AU (1) AU4262299A (de)
DE (1) DE69920906T2 (de)
ES (1) ES2230895T3 (de)
GB (1) GB9810659D0 (de)
PT (1) PT1080082E (de)
WO (1) WO1999059985A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US20050043376A1 (en) * 1996-12-03 2005-02-24 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6989450B2 (en) 2000-10-13 2006-01-24 The University Of Mississippi Synthesis of epothilones and related analogs
DE10164592A1 (de) * 2001-12-21 2003-07-03 Schering Ag C1-C6-Epothilon-Fragmente und Verfahren für die Herstellung von C1-C6-Fragmenten von Epothilonen und deren Derivaten
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1767535B1 (de) 2002-08-23 2009-12-02 Sloan-Kettering Institute For Cancer Research Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
GB0221312D0 (en) * 2002-09-13 2002-10-23 Novartis Ag Organic compounds
EP1589011A1 (de) 2004-04-22 2005-10-26 Schering Aktiengesellschaft Neue chirale Heptin Derivate zur Herstellung von Epothilonen und Verfahren zu deren Herstellung
CN103037903A (zh) 2010-05-18 2013-04-10 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59609305D1 (de) * 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
EP0923583A1 (de) * 1996-08-30 1999-06-23 Novartis AG Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
DE19820599A1 (de) 1998-05-08 1999-11-11 Biotechnolog Forschung Gmbh Epothilonderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19826988A1 (de) 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
AU5036999A (en) 1998-06-30 2000-01-17 Schering Aktiengesellschaft Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
CN1205208C (zh) * 1999-02-22 2005-06-08 生物技术研究股份有限公司 C－21修饰的环氧噻酮类化合物
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones

Also Published As

Publication number Publication date
GB9810659D0 (en) 1998-07-15
ES2230895T3 (es) 2005-05-01
WO1999059985A1 (en) 1999-11-25
DE69920906D1 (de) 2004-11-11
US6350878B1 (en) 2002-02-26
DE69920906T2 (de) 2006-03-09
PT1080082E (pt) 2005-02-28
EP1080082B1 (de) 2004-10-06
AU4262299A (en) 1999-12-06
EP1080082A1 (de) 2001-03-07

Similar Documents

Publication Publication Date Title
ATE278679T1 (de) Zwischenprodukte in der synthese von epothilonen und verfahren zu deren herstellung
NO940038D0 (no) Arylsulfonamido-substituerte hydrokamsyrer
ATE184194T1 (de) Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton
IS6257A (is) Frumuviðloðunartálmar
NO307047B1 (no) Nye hydroksyetylaminosulfonamider som er nyttige som retrovirale proteasehemmere, farmasøytisk preparat inneholdende slike, og anvendelse derav
DE69937045D1 (de) Cyclische amidderivate
TR200001239T2 (tr) Tiyazolidinediyon türevlerini hazırlama prosesi.
DK0595111T3 (da) Carbazolonderivater og fremgangsmåde til deres fremstilling
ATE159728T1 (de) Cis-epoxide derivate, verwendbar als irreversible hiv-protease inhibitoren und verfahren und zwischenprodukte zu ihrer herstellung
HRP20000467B1 (en) Process for the preparation of simvastatin and derivatives thereof
DE60014936D1 (de) Trizyklische dihydrobenzofurane, verfahren zu deren herstellung und mittel
ATE322470T1 (de) Funktionalisierte höhere diamantoide
DE60000402D1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
ATE189886T1 (de) Synthese von carbonsäurederivaten
ATE423089T1 (de) Verfahren zur herstellung von butantriol- derivaten
MX9803552A (es) Metodos para producir aminofenilsulfonil carbamidas y productos intermediarios para usarse en el procedimiento.
NO20001541L (no) Nye substituerte dimeriske forbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem
CA2284646A1 (en) Synthesis of intermediates useful in preparing tricyclic compounds
ATE508109T1 (de) Verfahren zur herstellung von optisch aktiven sulfonamiden und zwischenprodukte zur deren synthese
WO2001021585A3 (de) Bis-(aziridino-1-hydroxyiminomethyl)-derivate, verfahren zu deren herstellung und deren verwendung als antitumormittel
ATE399779T1 (de) Zwischenprodukte für die herstellung von neuraminidase-inhibitor-konjugaten
YU37902A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3- benzazocini i njihova primena kao lekova
ATE340157T1 (de) Zwischenprodukte, verfahren für deren herstellung und deren gebrauch
ATE244217T1 (de) Herstellung von beta-mehtylcarbapenem- zwischenprodukten
DE69916287D1 (de) Verfahren zur synthese von carbapenem-zwischenprodukten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1080082

Country of ref document: EP