ATE273258T1 - Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien - Google Patents

Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Info

Publication number
ATE273258T1
ATE273258T1 AT01906624T AT01906624T ATE273258T1 AT E273258 T1 ATE273258 T1 AT E273258T1 AT 01906624 T AT01906624 T AT 01906624T AT 01906624 T AT01906624 T AT 01906624T AT E273258 T1 ATE273258 T1 AT E273258T1
Authority
AT
Austria
Prior art keywords
enantioselectivity
borohydride
borane
prochiral substrate
reductions
Prior art date
Application number
AT01906624T
Other languages
English (en)
Inventor
Karl Matos
Joseph A Ii Corella
Elizabeth R Burkhardt
Shawn M Nettles
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of ATE273258T1 publication Critical patent/ATE273258T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
AT01906624T 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien ATE273258T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/553,264 US6218585B1 (en) 2000-04-20 2000-04-20 Increasing enatioselectivity in reductions with borane reagents
PCT/US2001/002069 WO2001081277A1 (en) 2000-04-20 2001-01-22 Increasing enantioselectivity in reductions with borane reagents

Publications (1)

Publication Number Publication Date
ATE273258T1 true ATE273258T1 (de) 2004-08-15

Family

ID=24208775

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906624T ATE273258T1 (de) 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Country Status (7)

Country Link
US (2) US6218585B1 (de)
EP (1) EP1274666B1 (de)
AT (1) ATE273258T1 (de)
AU (1) AU2001234510A1 (de)
DE (1) DE60104839T2 (de)
ES (1) ES2223784T3 (de)
WO (1) WO2001081277A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents
FR2824830B1 (fr) * 2001-05-18 2003-07-04 Centre Nat Rech Scient Catalyseur pour reduction enantioselective de cetones
US7767833B2 (en) * 2004-08-12 2010-08-03 Sigma-Aldrich Co. Stabilized borane-tetrahydrofuran complex
US20080200672A1 (en) * 2005-08-30 2008-08-21 Margarita Ortiz-Marciales Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
MX2008010235A (es) * 2006-02-16 2008-10-23 Kotobuki Pharmaceutical Co Ltd Metodo para producir alcohol opticamente activo.
DE602007008564D1 (en) * 2006-06-26 2010-09-30 Basf Se Boranetherkomplexe
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
US20100016484A1 (en) * 2008-07-18 2010-01-21 Basf Se Process for producing 1,3,2-dioxaborinane compounds
WO2017136254A1 (en) * 2016-02-04 2017-08-10 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US6048985A (en) * 1998-12-22 2000-04-11 Mine Safety Appliances Company Borane-tetrahydrofuran complex method of storing and reacting borane-tetrahydrofuran complex
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents

Also Published As

Publication number Publication date
US6218585B1 (en) 2001-04-17
US20010047116A1 (en) 2001-11-29
WO2001081277A1 (en) 2001-11-01
EP1274666A1 (de) 2003-01-15
DE60104839T2 (de) 2005-01-05
EP1274666B1 (de) 2004-08-11
DE60104839D1 (de) 2004-09-16
AU2001234510A1 (en) 2001-11-07
ES2223784T3 (es) 2005-03-01
US6610894B2 (en) 2003-08-26

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