ATE266037T1 - Verfahren zur herstellung von phoshphorothioate triestere - Google Patents

Verfahren zur herstellung von phoshphorothioate triestere

Info

Publication number
ATE266037T1
ATE266037T1 AT01907898T AT01907898T ATE266037T1 AT E266037 T1 ATE266037 T1 AT E266037T1 AT 01907898 T AT01907898 T AT 01907898T AT 01907898 T AT01907898 T AT 01907898T AT E266037 T1 ATE266037 T1 AT E266037T1
Authority
AT
Austria
Prior art keywords
triestere
phoshphorothioate
producing
phosphonate
alcohol
Prior art date
Application number
AT01907898T
Other languages
English (en)
Inventor
Colin Bernard Reese
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of ATE266037T1 publication Critical patent/ATE266037T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
AT01907898T 2000-03-01 2001-02-23 Verfahren zur herstellung von phoshphorothioate triestere ATE266037T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004889.2A GB0004889D0 (en) 2000-03-01 2000-03-01 Synthesis of oligonucleotides
PCT/GB2001/000764 WO2001064702A1 (en) 2000-03-01 2001-02-23 Process for the preparation of phosphorothioate triesters

Publications (1)

Publication Number Publication Date
ATE266037T1 true ATE266037T1 (de) 2004-05-15

Family

ID=9886705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01907898T ATE266037T1 (de) 2000-03-01 2001-02-23 Verfahren zur herstellung von phoshphorothioate triestere

Country Status (21)

Country Link
US (1) US7022833B2 (de)
EP (1) EP1272501B1 (de)
JP (1) JP2003525305A (de)
KR (1) KR20030032924A (de)
CN (1) CN1262557C (de)
AT (1) ATE266037T1 (de)
AU (2) AU2001235766B2 (de)
BR (1) BR0108771A (de)
CA (1) CA2401083A1 (de)
CZ (1) CZ20022930A3 (de)
DE (1) DE60103145T2 (de)
DK (1) DK1272501T3 (de)
ES (1) ES2220721T3 (de)
GB (1) GB0004889D0 (de)
HU (1) HUP0204249A3 (de)
IL (1) IL151238A0 (de)
MX (1) MXPA02008530A (de)
NO (1) NO20024155L (de)
NZ (1) NZ520778A (de)
PL (1) PL362067A1 (de)
WO (1) WO2001064702A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
AU2002339175A1 (en) * 2001-11-21 2003-06-10 Avecia Biotechnology Inc. Coupling reagent for h-phosphonate chemistry
EP1386925A1 (de) * 2002-07-31 2004-02-04 Girindus AG Verfahren zur Herstellung von Oligonukleotiden
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
RU2014105311A (ru) * 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501465D0 (en) * 1995-01-25 1995-03-15 King S College London Nucleoside phosphorothioate derivatives,synthesis and use thereof
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
GB9924285D0 (en) * 1999-10-14 1999-12-15 Avecia Ltd Process

Also Published As

Publication number Publication date
NO20024155D0 (no) 2002-08-30
NO20024155L (no) 2002-10-24
JP2003525305A (ja) 2003-08-26
MXPA02008530A (es) 2003-02-12
HUP0204249A2 (hu) 2003-04-28
GB0004889D0 (en) 2000-04-19
CA2401083A1 (en) 2001-09-07
ES2220721T3 (es) 2004-12-16
CN1406242A (zh) 2003-03-26
CN1262557C (zh) 2006-07-05
US20030099981A1 (en) 2003-05-29
CZ20022930A3 (cs) 2002-11-13
WO2001064702A1 (en) 2001-09-07
AU3576601A (en) 2001-09-12
KR20030032924A (ko) 2003-04-26
EP1272501B1 (de) 2004-05-06
US7022833B2 (en) 2006-04-04
DE60103145T2 (de) 2005-05-04
BR0108771A (pt) 2002-11-26
HUP0204249A3 (en) 2004-08-30
PL362067A1 (en) 2004-10-18
AU2001235766B2 (en) 2005-01-27
DK1272501T3 (da) 2004-08-16
DE60103145D1 (de) 2004-06-09
IL151238A0 (en) 2003-04-10
NZ520778A (en) 2004-05-28
EP1272501A1 (de) 2003-01-08

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Legal Events

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