ATE266017T1 - Radicicolderivate - Google Patents

Radicicolderivate

Info

Publication number
ATE266017T1
ATE266017T1 AT97909629T AT97909629T ATE266017T1 AT E266017 T1 ATE266017 T1 AT E266017T1 AT 97909629 T AT97909629 T AT 97909629T AT 97909629 T AT97909629 T AT 97909629T AT E266017 T1 ATE266017 T1 AT E266017T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
lower alkyl
alkanoyl
tert
Prior art date
Application number
AT97909629T
Other languages
English (en)
Inventor
Yoji Ino
Nobuyoshi Amishiro
Mayumi Miyata
Chikara Murakata
Harumi Ogawa
Tadakazu Akiyama
Shiro Akinaga
Shiroh Soga
Yukimasa Shiotsu
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE266017T1 publication Critical patent/ATE266017T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Furan Compounds (AREA)
AT97909629T 1996-10-25 1997-10-24 Radicicolderivate ATE266017T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28443996 1996-10-25
JP357897 1997-01-13
PCT/JP1997/003874 WO1998018780A1 (fr) 1996-10-25 1997-10-24 Derives de radicicol

Publications (1)

Publication Number Publication Date
ATE266017T1 true ATE266017T1 (de) 2004-05-15

Family

ID=26337204

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97909629T ATE266017T1 (de) 1996-10-25 1997-10-24 Radicicolderivate

Country Status (12)

Country Link
US (4) US6316491B1 (de)
EP (1) EP0889042B1 (de)
KR (1) KR19990076764A (de)
CN (1) CN1211244A (de)
AT (1) ATE266017T1 (de)
AU (1) AU727722B2 (de)
CA (1) CA2241624A1 (de)
DE (1) DE69728974T2 (de)
ES (1) ES2216130T3 (de)
NO (1) NO982960L (de)
NZ (1) NZ331062A (de)
WO (1) WO1998018780A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838810B1 (en) * 1997-03-21 2005-01-04 Chunghwa Picture Tubes, Ltd. Flat-panel display mounting system for portable computer
WO1998051702A1 (en) 1997-05-14 1998-11-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins
WO1999055689A1 (fr) * 1998-04-24 1999-11-04 Kyowa Hakko Kogyo Co., Ltd. Derives de radicicol
AU779438B2 (en) 1998-12-24 2005-01-27 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
WO2000045805A2 (en) * 1999-02-08 2000-08-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of inhibiting the hgf-met-upa-plasmin network with geldanamycin derivates
CA2370007A1 (en) 1999-04-09 2000-10-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
US7238682B1 (en) 1999-04-09 2007-07-03 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of HER-family tyrosine kinases
US6979574B1 (en) * 1999-08-06 2005-12-27 Institut Fuer Diagnostik Forshung Gmbh Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
AU2001292548B2 (en) * 2000-07-28 2005-06-16 Sloan-Kettering Institute For Cancer Research Methods for treating cell proliferative disorders and viral infections
WO2002016369A2 (en) * 2000-08-25 2002-02-28 Sloan-Kettering Institute For Cancer Research Novel macrocycles and uses thereof
WO2002094196A2 (en) * 2001-05-23 2002-11-28 Sloan Kettering Institute For Cancer Research Method of treatment for cancers associated with elevated
JP4750360B2 (ja) 2001-10-22 2011-08-17 ザ スクリプス リサーチ インスティチュート 抗体ターゲッティング化合物
AU2002337954C1 (en) * 2001-10-22 2008-10-23 The Scripps Research Institute Integrin targeting compounds
AU2004251949B2 (en) 2003-06-27 2009-05-07 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
WO2005061481A1 (en) * 2003-12-19 2005-07-07 Sloan-Kettering Institute For Cancer Research Novel ma crocycles and uses thereof
EP2583678A3 (de) 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner Moleküle und Assays für deren Nachweis
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
GB0526615D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
EP2136799B1 (de) * 2006-08-11 2017-10-04 Universite De Strasbourg Makrocyclische verbindungen als hemmer von kinase und hsp90
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
AU2009206097B2 (en) * 2008-01-15 2014-08-14 Sofia Barluenga Synthesis of resorcylic acid lactones useful as therapeutic agents
AU2009217315B2 (en) * 2008-02-21 2014-09-04 Oncosynergy, Inc. Macrocyclic prodrug compounds useful as therapeutics
LT5623B (lt) 2008-04-30 2010-01-25 Biotechnologijos Institutas, , 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650430A (en) 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
KR920000763A (ko) 1990-06-06 1992-01-29 가와무라 요시부미 라디시콜 유도체, 그 제조방법 및 그의 항종양 활성
JP3055967B2 (ja) 1990-06-06 2000-06-26 三共株式会社 ラディシコール誘導体
JPH06279279A (ja) * 1993-03-26 1994-10-04 Tsumura & Co 血管新生阻害剤
JPH06298764A (ja) 1993-04-15 1994-10-25 Kyowa Hakko Kogyo Co Ltd 免疫抑制剤
JPH0840893A (ja) * 1993-08-31 1996-02-13 Takeda Chem Ind Ltd インターロイキン−1産生抑制剤
US5731343A (en) * 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
HUP9901344A3 (en) 1995-04-26 2001-05-28 Kyowa Hakko Kogyo Kk Radicicol derivatives and pharmaceutical compositions thereof
JPH09202781A (ja) * 1996-01-25 1997-08-05 Sankyo Co Ltd ラディシコール誘導体

Also Published As

Publication number Publication date
EP0889042A4 (de) 1999-10-06
CN1211244A (zh) 1999-03-17
DE69728974T2 (de) 2005-03-31
AU4723997A (en) 1998-05-22
US20040053990A1 (en) 2004-03-18
US6239168B1 (en) 2001-05-29
WO1998018780A1 (fr) 1998-05-07
US6635662B2 (en) 2003-10-21
NZ331062A (en) 2000-05-26
US6316491B1 (en) 2001-11-13
KR19990076764A (ko) 1999-10-15
EP0889042A1 (de) 1999-01-07
AU727722B2 (en) 2000-12-21
ES2216130T3 (es) 2004-10-16
EP0889042B1 (de) 2004-05-06
US20010027208A1 (en) 2001-10-04
CA2241624A1 (en) 1998-05-07
DE69728974D1 (de) 2004-06-09
NO982960D0 (no) 1998-06-25
NO982960L (no) 1998-08-25

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties