ATE266015T1 - Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel - Google Patents

Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel

Info

Publication number: ATE266015T1
Authority: AT; Austria
Prior art keywords: methyl carbonate; analogo; paclitaxel; preparing; deacetylbaccatin
Prior art date: 1999-08-11

Application number

AT00952478T

Other languages

English (en)

Inventor

Joydeep Kant

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-11

Filing date

2000-08-03

Publication date

2004-05-15

2000-08-03 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266015T1 publication Critical patent/ATE266015T1/de

Links

238000000034 method Methods 0.000 title abstract 2
229930012538 Paclitaxel Natural products 0.000 title 1
CXHHBNMLPJOKQD-UHFFFAOYSA-M methyl carbonate Chemical compound COC([O-])=O CXHHBNMLPJOKQD-UHFFFAOYSA-M 0.000 title 1
229960001592 paclitaxel Drugs 0.000 title 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
-1 C-4 methyl carbonate paclitaxel analog Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT00952478T 1999-08-11 2000-08-03 Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel ATE266015T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14839299P	1999-08-11	1999-08-11
PCT/US2000/021260 WO2001010856A1 (en)	1999-08-11	2000-08-03	Process for the preparation of a paclitaxel c-4 methyl carbonate analog

Publications (1)

Publication Number	Publication Date
ATE266015T1 true ATE266015T1 (de)	2004-05-15

Family

ID=22525581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00952478T ATE266015T1 (de)	1999-08-11	2000-08-03	Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel

Country Status (18)

Country	Link
US (2)	US6248908B1 (de)
EP (1)	EP1206461B8 (de)
JP (1)	JP2003506446A (de)
KR (1)	KR100634249B1 (de)
AT (1)	ATE266015T1 (de)
AU (1)	AU769858B2 (de)
CA (1)	CA2381401A1 (de)
DE (1)	DE60010476T2 (de)
DK (1)	DK1206461T3 (de)
ES (1)	ES2219372T3 (de)
HU (1)	HUP0202448A3 (de)
IL (2)	IL147851A0 (de)
MX (1)	MXPA02001396A (de)
PE (1)	PE20010493A1 (de)
PT (1)	PT1206461E (de)
TW (1)	TWI269792B (de)
UY (1)	UY26284A1 (de)
WO (1)	WO2001010856A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
US6916942B2 (en) *	2000-02-03	2005-07-12	Bristol-Myers Squibb Company	Process for the preparation of C-4 carbonate taxanes
EP1318794A2 (de) *	2000-09-22	2003-06-18	Bristol-Myers Squibb Company	Methode zur reduktion der toxizität von kombinationschemotherapien
KR20040066921A (ko) *	2001-12-20	2004-07-27	브리스톨-마이어스스퀴브컴파니	생체이용률이 향상된 경구 활성 탁산 유도체의 제약조성물
US20070105944A1 (en) *	2002-10-25	2007-05-10	Comezoglu S N	Taxane metabolites
WO2005070414A1 (en) *	2004-01-14	2005-08-04	Virginia Tech Intellectual Properties, Inc.	Conformationally constrained paclitaxel analogs and their use as anticancer and anti-alzheimers agents
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
PL217731B1 (pl)	2006-06-01	2014-08-29	Tomasz Byrski	Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
UY30639A1 (es)	2006-10-17	2008-05-31	Kudos Pharm Ltd	Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US20080280910A1 (en) *	2007-03-22	2008-11-13	Keith Allan Menear	Phthalazinone derivatives
CN102238945B (zh)	2008-10-07	2014-10-29	阿斯利康(英国)有限公司	药物制剂514

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE34277E (en)	1988-04-06	1993-06-08	Centre National De La Recherche Scientifique	Process for preparing taxol
US5990325A (en) *	1993-03-05	1999-11-23	Florida State University	Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5399726A (en) *	1993-01-29	1995-03-21	Florida State University	Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5274124A (en)	1991-09-23	1993-12-28	Florida State University	Metal alkoxides
SE470504B (sv) *	1992-10-27	1994-06-06	Ellemtel Utvecklings Ab	Sätt att i ett GSM-nät ta emot data för tilläggstjänster i MSC/VLR.
CZ292993B6 (cs) *	1992-12-23	2004-01-14	Bristol-Myers Squibb Company	Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený
CA2259977C (en) *	1996-07-15	2005-06-28	Kabushiki Kaisha Yakult Honsha	Taxane derivatives and drugs containing the same

2000
- 2000-08-03 CA CA002381401A patent/CA2381401A1/en not_active Abandoned
- 2000-08-03 IL IL14785100A patent/IL147851A0/xx not_active IP Right Cessation
- 2000-08-03 DE DE60010476T patent/DE60010476T2/de not_active Expired - Fee Related
- 2000-08-03 JP JP2001515665A patent/JP2003506446A/ja not_active Withdrawn
- 2000-08-03 AT AT00952478T patent/ATE266015T1/de not_active IP Right Cessation
- 2000-08-03 WO PCT/US2000/021260 patent/WO2001010856A1/en active IP Right Grant
- 2000-08-03 AU AU65169/00A patent/AU769858B2/en not_active Ceased
- 2000-08-03 MX MXPA02001396A patent/MXPA02001396A/es active IP Right Grant
- 2000-08-03 PT PT00952478T patent/PT1206461E/pt unknown
- 2000-08-03 ES ES00952478T patent/ES2219372T3/es not_active Expired - Lifetime
- 2000-08-03 DK DK00952478T patent/DK1206461T3/da active
- 2000-08-03 HU HU0202448A patent/HUP0202448A3/hu unknown
- 2000-08-03 KR KR1020027001746A patent/KR100634249B1/ko not_active IP Right Cessation
- 2000-08-03 EP EP00952478A patent/EP1206461B8/de not_active Expired - Lifetime
- 2000-08-07 TW TW089115879A patent/TWI269792B/zh not_active IP Right Cessation
- 2000-08-08 PE PE2000000802A patent/PE20010493A1/es not_active Application Discontinuation
- 2000-08-08 UY UY26284A patent/UY26284A1/es not_active Application Discontinuation
- 2000-08-10 US US09/635,553 patent/US6248908B1/en not_active Expired - Fee Related
2001
- 2001-03-20 US US09/813,085 patent/US6353120B2/en not_active Expired - Fee Related
2005
- 2005-05-11 IL IL168553A patent/IL168553A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU769858B2 (en)	2004-02-05
TWI269792B (en)	2007-01-01
HUP0202448A2 (hu)	2002-11-28
US6248908B1 (en)	2001-06-19
KR20020031405A (ko)	2002-05-01
WO2001010856A1 (en)	2001-02-15
UY26284A1 (es)	2001-03-16
EP1206461A1 (de)	2002-05-22
HUP0202448A3 (en)	2005-02-28
EP1206461A4 (de)	2003-03-26
IL147851A0 (en)	2002-08-14
DE60010476D1 (de)	2004-06-09
US20010044549A1 (en)	2001-11-22
DE60010476T2 (de)	2005-04-14
DK1206461T3 (da)	2004-08-16
EP1206461B8 (de)	2004-07-21
AU6516900A (en)	2001-03-05
MXPA02001396A (es)	2002-08-12
PT1206461E (pt)	2004-09-30
PE20010493A1 (es)	2001-07-06
KR100634249B1 (ko)	2006-10-17
EP1206461B1 (de)	2004-05-06
ES2219372T3 (es)	2004-12-01
CA2381401A1 (en)	2001-02-15
US6353120B2 (en)	2002-03-05
JP2003506446A (ja)	2003-02-18
IL168553A (en)	2007-07-04

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