ATE264846T1 - Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen - Google Patents
Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionenInfo
- Publication number
- ATE264846T1 ATE264846T1 AT98908758T AT98908758T ATE264846T1 AT E264846 T1 ATE264846 T1 AT E264846T1 AT 98908758 T AT98908758 T AT 98908758T AT 98908758 T AT98908758 T AT 98908758T AT E264846 T1 ATE264846 T1 AT E264846T1
- Authority
- AT
- Austria
- Prior art keywords
- benzimidazole derivatives
- substituted benzimidazole
- retroviral infections
- treating retroviral
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/808,321 US5935982A (en) | 1997-02-28 | 1997-02-28 | Methods of treating retroviral infection and compounds useful therefor |
PCT/US1998/003830 WO1998038170A1 (en) | 1997-02-28 | 1998-02-27 | Substituted benzimidazoles and their use for treating retroviral infection |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE264846T1 true ATE264846T1 (de) | 2004-05-15 |
Family
ID=25198455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98908758T ATE264846T1 (de) | 1997-02-28 | 1998-02-27 | Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5935982A (de) |
EP (1) | EP0973750B1 (de) |
JP (1) | JP2002513404A (de) |
AT (1) | ATE264846T1 (de) |
AU (1) | AU738975B2 (de) |
CA (1) | CA2282552A1 (de) |
DE (1) | DE69823344T2 (de) |
HK (1) | HK1026691A1 (de) |
WO (1) | WO1998038170A1 (de) |
Families Citing this family (66)
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US6142163A (en) * | 1996-03-29 | 2000-11-07 | Lam Research Corporation | Method and apparatus for pressure control in vacuum processors |
ATE504572T1 (de) * | 1999-09-02 | 2011-04-15 | Shionogi & Co | Derivate von aromatische heterocyclen enthaltende integraseinhibitoren |
US7115665B1 (en) | 2000-11-16 | 2006-10-03 | Onocozyme Pharma, Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
CA2388674C (en) * | 1999-11-16 | 2005-01-25 | Oncozyme Pharma Inc | Inhibitors of endo-exonuclease activity for treating cancer |
US6242461B1 (en) * | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
US20040039060A1 (en) * | 2000-06-14 | 2004-02-26 | Ryuichi Kiyama | Inhibitor for enzyme having two divalent metal ions as active centers |
WO2002002516A2 (en) * | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
US20020124843A1 (en) * | 2001-02-01 | 2002-09-12 | Skiba Jeffry B. | Eye medication delivery system |
US6710068B2 (en) | 2001-04-11 | 2004-03-23 | Idenix Pharmaceuticals, Inc. | Phenylindoles for the treatment of HIV |
US6958211B2 (en) * | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
IL160208A0 (en) * | 2001-08-31 | 2004-07-25 | Neurochem Int Ltd | Amidine derivatives for treating amyloidosis |
US7365090B2 (en) * | 2002-08-07 | 2008-04-29 | Idenix Pharmaceuticals, Inc. | Substituted phenylindoles for the treatment of HIV |
DE602004021211D1 (de) * | 2003-03-07 | 2009-07-09 | Merck Patent Gmbh | Fluorene und Arylgruppen enthaltende Mono-, Oligo- und Polymere |
US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
CA2561718A1 (en) | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
EP1799696B1 (de) | 2004-09-17 | 2008-11-12 | IDENIX Pharmaceuticals, Inc. | Phosphoindole als hiv-inhibitoren |
AU2007305447A1 (en) | 2006-09-29 | 2008-04-10 | Idenix Pharmaceuticals, Inc | Enantiomerically pure phosphoindoles as HIV inhibitors |
EP2367824B1 (de) * | 2008-12-23 | 2016-03-23 | AbbVie Inc. | Antivirale Pyrimidinderivate |
EP2367823A1 (de) * | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Antivirale verbindungen |
US8314135B2 (en) * | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8242156B2 (en) * | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8188132B2 (en) * | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
SG175144A1 (en) * | 2009-04-15 | 2011-11-28 | Abbott Lab | Anti-viral compounds |
EP2430015B1 (de) * | 2009-05-12 | 2015-06-17 | Merck Sharp & Dohme Corp. | Für die behandlung von viruserkrankungen geeignete kondensierte tricyclische arylverbindungen |
WO2010138791A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
JP2012528194A (ja) | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | C型肝炎などの疾患を処置するための3つの整列型アリール部分で構成された抗菌性化合物 |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
JP5530514B2 (ja) * | 2009-06-11 | 2014-06-25 | アッヴィ・バハマズ・リミテッド | Hcv感染を治療するための抗ウィルス化合物 |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
WO2010148006A1 (en) * | 2009-06-16 | 2010-12-23 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8759332B2 (en) * | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US9156818B2 (en) * | 2009-09-11 | 2015-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8822700B2 (en) * | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8927709B2 (en) * | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8703938B2 (en) * | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011081918A1 (en) * | 2009-12-14 | 2011-07-07 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
EA201201031A1 (ru) | 2010-01-25 | 2013-02-28 | Энанта Фармасьютиклз, Инк. | Ингибиторы вируса гепатита с |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8178531B2 (en) * | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
WO2011109037A1 (en) * | 2010-03-04 | 2011-09-09 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as inhibitors of hcv replication |
MA34147B1 (fr) * | 2010-03-09 | 2013-04-03 | Merck Sharp & Dohme | Composes tricycliques fusionnes de silyle et leurs methodes d'utilisation dans le cadre du traitement de maladies virales |
WO2011127350A1 (en) | 2010-04-09 | 2011-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
EP2575819A4 (de) | 2010-06-04 | 2013-11-27 | Enanta Pharm Inc | Hemmer des hepatitis-c-virus |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
WO2012021704A1 (en) | 2010-08-12 | 2012-02-16 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
CN103687489A (zh) | 2011-05-18 | 2014-03-26 | 埃南塔制药公司 | 制备5-氮杂螺[2.4]庚烷-6-甲酸及其衍生物的方法 |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
EP2749560B1 (de) | 2012-04-13 | 2019-10-02 | LG Chem, Ltd. | Neuartige stickstoffhaltige heterozyklische Verbindungen und deren Verwendung in organischen elektronischen Vorrichtungen |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
EP3089757A1 (de) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Feste antivirale darreichungsformen |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
WO2017223260A1 (en) | 2016-06-23 | 2017-12-28 | Albert Einstein College Of Medicine, Inc. | Pu.1 inhibitors |
CN109553608B (zh) * | 2017-09-26 | 2020-12-08 | 北京大学 | 一类五元六元杂环化合物及其制备方法和***的用途 |
CN113264925A (zh) * | 2020-02-14 | 2021-08-17 | 上海美悦生物科技发展有限公司 | 一种杂环化合物及其制备方法和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2839989A1 (de) * | 1978-09-14 | 1980-04-03 | Hoechst Ag | Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung |
US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
DE4212748A1 (de) * | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
WO1995008540A1 (en) * | 1993-09-22 | 1995-03-30 | The Wellcome Foundation Limited | Bis(amidinobenzimidazolyl)alkanes as antiviral agents |
US6815461B1 (en) * | 1994-01-20 | 2004-11-09 | The University Of North Carolina At Chapel Hill | Method of inhibiting retroviral integrase |
ES2157268T5 (es) * | 1994-02-24 | 2004-12-01 | SYMRISE GMBH & CO KG | Preparados cosmeticos y dermatologicos que contienen acidos fenilen-1,4-bisbencimidazolsulfonicos. |
US5602172A (en) * | 1994-05-06 | 1997-02-11 | The University Of North Carolina At Chapel Hill | Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor |
US5667975A (en) * | 1994-05-06 | 1997-09-16 | The University Of North Carolina | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans |
US5668167A (en) * | 1995-06-07 | 1997-09-16 | Duke University | Methods of treating microbial infections |
US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
-
1997
- 1997-02-28 US US08/808,321 patent/US5935982A/en not_active Expired - Fee Related
-
1998
- 1998-02-27 AT AT98908758T patent/ATE264846T1/de not_active IP Right Cessation
- 1998-02-27 EP EP98908758A patent/EP0973750B1/de not_active Expired - Lifetime
- 1998-02-27 CA CA002282552A patent/CA2282552A1/en not_active Abandoned
- 1998-02-27 AU AU66707/98A patent/AU738975B2/en not_active Ceased
- 1998-02-27 JP JP53787098A patent/JP2002513404A/ja not_active Ceased
- 1998-02-27 DE DE69823344T patent/DE69823344T2/de not_active Expired - Fee Related
- 1998-02-27 WO PCT/US1998/003830 patent/WO1998038170A1/en active IP Right Grant
-
2000
- 2000-07-24 HK HK00104566A patent/HK1026691A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU738975B2 (en) | 2001-10-04 |
AU6670798A (en) | 1998-09-18 |
CA2282552A1 (en) | 1998-09-03 |
EP0973750A1 (de) | 2000-01-26 |
US5935982A (en) | 1999-08-10 |
JP2002513404A (ja) | 2002-05-08 |
DE69823344T2 (de) | 2005-05-12 |
HK1026691A1 (en) | 2000-12-22 |
DE69823344D1 (de) | 2004-05-27 |
EP0973750B1 (de) | 2004-04-21 |
WO1998038170A1 (en) | 1998-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |