ATE264683T1 - Verfahren zur herstellung wasserdispergierbare sterol formulierungen - Google Patents
Verfahren zur herstellung wasserdispergierbare sterol formulierungenInfo
- Publication number
- ATE264683T1 ATE264683T1 AT99301209T AT99301209T ATE264683T1 AT E264683 T1 ATE264683 T1 AT E264683T1 AT 99301209 T AT99301209 T AT 99301209T AT 99301209 T AT99301209 T AT 99301209T AT E264683 T1 ATE264683 T1 AT E264683T1
- Authority
- AT
- Austria
- Prior art keywords
- disppersible
- producing water
- sterol
- sterol formulations
- sitosterol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Seeds, Soups, And Other Foods (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/025,952 US6110502A (en) | 1998-02-19 | 1998-02-19 | Method for producing water dispersible sterol formulations |
US09/185,788 US6054144A (en) | 1998-02-19 | 1998-11-04 | Method for producing water dispersible sterol formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE264683T1 true ATE264683T1 (de) | 2004-05-15 |
Family
ID=26700515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99301209T ATE264683T1 (de) | 1998-02-19 | 1999-02-18 | Verfahren zur herstellung wasserdispergierbare sterol formulierungen |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0947197B1 (de) |
JP (1) | JPH11313644A (de) |
CN (1) | CN1161123C (de) |
AT (1) | ATE264683T1 (de) |
AU (1) | AU760314B2 (de) |
BR (1) | BR9902325A (de) |
CZ (1) | CZ298506B6 (de) |
DE (1) | DE69916522T2 (de) |
DK (1) | DK0947197T3 (de) |
ES (1) | ES2216439T3 (de) |
HU (1) | HUP9900434A2 (de) |
IN (1) | IN185730B (de) |
NO (1) | NO990747L (de) |
NZ (1) | NZ334189A (de) |
PL (1) | PL192906B1 (de) |
PT (1) | PT947197E (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE512958C2 (sv) * | 1998-04-30 | 2000-06-12 | Triple Crown Ab | Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning |
US6123978A (en) * | 1998-08-31 | 2000-09-26 | Mcneil-Ppc, Inc. | Stable salad dressings |
US6376481B2 (en) * | 1998-09-02 | 2002-04-23 | Mcneil-Ppc, Inc. | Sterol esters in tableted solid dosage forms |
US6677327B1 (en) | 1999-11-24 | 2004-01-13 | Archer-Daniels-Midland Company | Phytosterol and phytostanol compositions |
GB0021498D0 (en) * | 2000-09-01 | 2000-10-18 | Novartis Nutrition Ag | New formulation |
AU2005234649B2 (en) * | 2000-09-01 | 2008-01-17 | Forbes Medi-Tech, Inc. | Water-dispersible encapsulated sterols |
KR20020026053A (ko) * | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
GB0104074D0 (en) * | 2001-02-19 | 2001-04-04 | Novartis Ag | New composition |
US20030003131A1 (en) * | 2001-06-22 | 2003-01-02 | Matthew Dyer | Method for manufacture of free-flowing powder containing water-dispersible sterols |
CN1556699B (zh) | 2001-07-24 | 2010-05-12 | 嘉吉有限公司 | 分离酚类化合物的方法 |
WO2003077680A1 (en) * | 2002-03-20 | 2003-09-25 | Eugene Science Inc. | Mixing powder of plant sterol and emulsifier, and method for preparing the same |
US6623780B1 (en) | 2002-03-26 | 2003-09-23 | Cargill, Inc. | Aqueous dispersible sterol product |
AU2003226031A1 (en) * | 2002-04-10 | 2003-10-27 | Thomas P Binder | Hydrothermically processed compositions containing phytosterols |
US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
ATE413820T1 (de) | 2002-06-12 | 2008-11-15 | Coca Cola Co | Pflanzliches sterol enthaltende getränke |
US7732000B2 (en) * | 2002-06-20 | 2010-06-08 | General Mills, Inc. | Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix |
US20060035009A1 (en) * | 2004-08-10 | 2006-02-16 | Kraft Foods Holdings, Inc. | Compositions and processes for water-dispersible phytosterols and phytostanols |
EP1835819A1 (de) * | 2005-01-14 | 2007-09-26 | Unilever N.V. | Beutel, die pflanzensterol enthalten |
DE102005008445A1 (de) | 2005-02-24 | 2006-08-31 | Cognis Ip Management Gmbh | Zuckerhaltige Sterolfeststoffdispersionen |
DE102005039835A1 (de) * | 2005-08-23 | 2007-03-01 | Cognis Ip Management Gmbh | Pulverförmige Sterolformulierungen mit Kolloidbildnern |
CN111529500B (zh) * | 2020-06-28 | 2021-09-24 | 江西谷物源食品有限公司 | 一种提高谷维素溶解度的药物组合物及其制备方法 |
CN112618665B (zh) * | 2020-12-19 | 2022-06-14 | 杭州益品新五丰药业有限公司 | 一种提高免疫反应的糠甾醇-谷维素联合用药制剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3881005A (en) * | 1973-08-13 | 1975-04-29 | Lilly Co Eli | Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof |
US4195084A (en) * | 1977-01-07 | 1980-03-25 | Eli Lilly And Company | Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof |
DE3829643A1 (de) * | 1988-09-01 | 1990-03-15 | Roecar Holdings Nv | Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit |
JP2656997B2 (ja) * | 1989-07-21 | 1997-09-24 | マリゲン ソシエテ アノニム | ステロールの脂肪酸エステルの抗腫瘍剤のための自発的分散性濃縮物及びそれを含む医薬組成物 |
CH681153A5 (de) * | 1991-01-28 | 1993-01-29 | Marigen S.A. | Neue sterolester- und sterolphosphorverbindungen. |
US5502045A (en) * | 1991-05-03 | 1996-03-26 | Raision Tehtaat Oy Ab | Use of a stanol fatty acid ester for reducing serum cholesterol level |
-
1999
- 1999-02-10 IN IN101CA1999 patent/IN185730B/en unknown
- 1999-02-15 NZ NZ334189A patent/NZ334189A/xx unknown
- 1999-02-16 JP JP11036991A patent/JPH11313644A/ja active Pending
- 1999-02-17 AU AU17358/99A patent/AU760314B2/en not_active Ceased
- 1999-02-18 ES ES99301209T patent/ES2216439T3/es not_active Expired - Lifetime
- 1999-02-18 EP EP99301209A patent/EP0947197B1/de not_active Expired - Lifetime
- 1999-02-18 AT AT99301209T patent/ATE264683T1/de active
- 1999-02-18 PL PL331546A patent/PL192906B1/pl not_active IP Right Cessation
- 1999-02-18 PT PT99301209T patent/PT947197E/pt unknown
- 1999-02-18 CZ CZ0054799A patent/CZ298506B6/cs not_active IP Right Cessation
- 1999-02-18 BR BR9902325-3A patent/BR9902325A/pt not_active Application Discontinuation
- 1999-02-18 DK DK99301209T patent/DK0947197T3/da active
- 1999-02-18 NO NO990747A patent/NO990747L/no not_active Application Discontinuation
- 1999-02-18 DE DE69916522T patent/DE69916522T2/de not_active Expired - Lifetime
- 1999-02-19 CN CNB991030001A patent/CN1161123C/zh not_active Expired - Fee Related
- 1999-02-19 HU HU9900434A patent/HUP9900434A2/hu unknown
Also Published As
Publication number | Publication date |
---|---|
NO990747L (no) | 1999-08-20 |
IN185730B (de) | 2001-04-14 |
CN1161123C (zh) | 2004-08-11 |
DE69916522T2 (de) | 2005-07-21 |
PL192906B1 (pl) | 2006-12-29 |
AU760314B2 (en) | 2003-05-15 |
NO990747D0 (no) | 1999-02-18 |
BR9902325A (pt) | 2000-04-11 |
CN1232668A (zh) | 1999-10-27 |
HU9900434D0 (en) | 1999-04-28 |
HUP9900434A2 (hu) | 2001-06-28 |
DE69916522D1 (de) | 2004-05-27 |
NZ334189A (en) | 1999-07-29 |
AU1735899A (en) | 2000-06-08 |
EP0947197A1 (de) | 1999-10-06 |
DK0947197T3 (da) | 2004-07-26 |
JPH11313644A (ja) | 1999-11-16 |
EP0947197B1 (de) | 2004-04-21 |
ES2216439T3 (es) | 2004-10-16 |
CZ54799A3 (cs) | 1999-09-15 |
PL331546A1 (en) | 1999-08-30 |
CZ298506B6 (cs) | 2007-10-24 |
PT947197E (pt) | 2004-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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