ATE259376T1 - Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren - Google Patents

Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren

Info

Publication number
ATE259376T1
ATE259376T1 AT00905282T AT00905282T ATE259376T1 AT E259376 T1 ATE259376 T1 AT E259376T1 AT 00905282 T AT00905282 T AT 00905282T AT 00905282 T AT00905282 T AT 00905282T AT E259376 T1 ATE259376 T1 AT E259376T1
Authority
AT
Austria
Prior art keywords
group
different
same
heterocyclic compounds
intermediate products
Prior art date
Application number
AT00905282T
Other languages
English (en)
Inventor
Fuminori Sato
Yasunao Inoue
Tomoki Omodani
Ryotaro Shiratake
Seiji Honda
Masanobu Komiya
Tadashi Takemura
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of ATE259376T1 publication Critical patent/ATE259376T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT00905282T 1999-03-03 2000-02-23 Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren ATE259376T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11056052A JP2000256396A (ja) 1999-03-03 1999-03-03 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
PCT/JP2000/001022 WO2000052032A1 (fr) 1999-03-03 2000-02-23 Composes heterocycliques, leurs intermediaires, et inhibiteurs d'elastase

Publications (1)

Publication Number Publication Date
ATE259376T1 true ATE259376T1 (de) 2004-02-15

Family

ID=13016323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00905282T ATE259376T1 (de) 1999-03-03 2000-02-23 Heterozyklische verbindungen, ihre zwischenprodukte und elastase-inhibitoren

Country Status (23)

Country Link
US (1) US6835714B1 (de)
EP (1) EP1157998B1 (de)
JP (1) JP2000256396A (de)
KR (1) KR100622709B1 (de)
CN (1) CN1183156C (de)
AT (1) ATE259376T1 (de)
AU (1) AU758739B2 (de)
CA (1) CA2362911A1 (de)
DE (1) DE60008218T2 (de)
DK (1) DK1157998T3 (de)
ES (1) ES2215608T3 (de)
HK (1) HK1044955B (de)
HU (1) HUP0200608A3 (de)
IL (2) IL144813A0 (de)
MX (1) MXPA01008836A (de)
NZ (1) NZ513594A (de)
PL (1) PL199136B1 (de)
PT (1) PT1157998E (de)
RU (1) RU2222539C2 (de)
TR (1) TR200102540T2 (de)
TW (1) TW534905B (de)
WO (1) WO2000052032A1 (de)
ZA (1) ZA200106514B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001267886A1 (en) 2000-06-30 2002-01-14 Seikagaku Corporation Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US7012066B2 (en) 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
CZ2003195A3 (cs) 2000-07-21 2003-04-16 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek
GB0021315D0 (en) * 2000-08-30 2000-10-18 Dainippon Pharmaceutical Co Heterocyclic compounds and intermediates thereof
CA2423945A1 (en) * 2000-09-29 2003-03-27 Atsushi Nagai Restrainers of airway mucus secretion
CA2473706A1 (en) 2002-02-05 2003-08-14 Dainippon Pharmaceutical Co., Ltd. Heterocyclic compounds having elastase-inhibitory activity and intermediates thereof
ATE438622T1 (de) 2004-02-27 2009-08-15 Schering Corp 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
MX2008014838A (es) * 2006-05-23 2008-12-05 Irm Llc Metodos y composiciones como inhibidores de proteasa de activacion de canal.
BRPI0712021A2 (pt) 2006-05-23 2012-01-03 Irm Llc composto e composiÇÕes como inibidores da protease ativadora de canal
US8142818B2 (en) * 2006-09-12 2012-03-27 Himalaya Global Holdings Limited Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof
MX2009008493A (es) * 2007-02-09 2009-08-20 Irm Llc Compuestos y composiciones como inhibidores de la proteasa activadora de canal.
CN101600428A (zh) * 2007-02-09 2009-12-09 Irm责任有限公司 作为通道活化蛋白酶抑制剂的化合物和组合物
TW201309698A (zh) 2011-03-18 2013-03-01 Ono Pharmaceutical Co 四氫咔啉衍生物
CN104031014B (zh) * 2013-03-08 2016-05-11 华中师范大学 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒
CN104165869B (zh) * 2013-05-17 2016-12-28 华中师范大学 一种检测蛋白水解酶活性的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
GB8600263D0 (en) 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
GB8809316D0 (en) 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
CA1340191C (en) 1988-06-13 1998-12-15 Katsuhiro Imaki Derivatives of p-substituted phenyl ester of pivalic acid
US5565568A (en) 1995-04-06 1996-10-15 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists

Also Published As

Publication number Publication date
ZA200106514B (en) 2002-05-10
CN1349542A (zh) 2002-05-15
EP1157998B1 (de) 2004-02-11
TR200102540T2 (tr) 2002-01-21
KR100622709B1 (ko) 2006-09-13
TW534905B (en) 2003-06-01
MXPA01008836A (es) 2002-05-14
CN1183156C (zh) 2005-01-05
US6835714B1 (en) 2004-12-28
IL144813A0 (en) 2002-06-30
NZ513594A (en) 2003-04-29
CA2362911A1 (en) 2000-09-08
HK1044955B (zh) 2005-07-08
DE60008218D1 (de) 2004-03-18
JP2000256396A (ja) 2000-09-19
DK1157998T3 (da) 2004-06-14
RU2222539C2 (ru) 2004-01-27
HK1044955A1 (en) 2002-11-08
WO2000052032A1 (fr) 2000-09-08
PT1157998E (pt) 2004-06-30
IL144813A (en) 2006-12-10
AU2690200A (en) 2000-09-21
HUP0200608A2 (en) 2002-08-28
ES2215608T3 (es) 2004-10-16
DE60008218T2 (de) 2004-12-09
KR20020002396A (ko) 2002-01-09
HUP0200608A3 (en) 2002-09-30
EP1157998A4 (de) 2003-01-29
PL199136B1 (pl) 2008-08-29
EP1157998A1 (de) 2001-11-28
AU758739B2 (en) 2003-03-27

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