ATE253037T1 - Verfahren zur racematspaltung von tramadol - Google Patents

Verfahren zur racematspaltung von tramadol

Info

Publication number
ATE253037T1
ATE253037T1 AT99973014T AT99973014T ATE253037T1 AT E253037 T1 ATE253037 T1 AT E253037T1 AT 99973014 T AT99973014 T AT 99973014T AT 99973014 T AT99973014 T AT 99973014T AT E253037 T1 ATE253037 T1 AT E253037T1
Authority
AT
Austria
Prior art keywords
tramadol
racemat
cleaving
single enantiomer
substantially single
Prior art date
Application number
AT99973014T
Other languages
English (en)
Inventor
Graham Evans
Original Assignee
Arakis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arakis Ltd filed Critical Arakis Ltd
Application granted granted Critical
Publication of ATE253037T1 publication Critical patent/ATE253037T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Fertilizers (AREA)
AT99973014T 1998-12-02 1999-11-18 Verfahren zur racematspaltung von tramadol ATE253037T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9826540.8A GB9826540D0 (en) 1998-12-02 1998-12-02 Process
PCT/GB1999/003843 WO2000032554A1 (en) 1998-12-02 1999-11-18 Process for the resolution of tramadol

Publications (1)

Publication Number Publication Date
ATE253037T1 true ATE253037T1 (de) 2003-11-15

Family

ID=10843543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99973014T ATE253037T1 (de) 1998-12-02 1999-11-18 Verfahren zur racematspaltung von tramadol

Country Status (12)

Country Link
US (1) US6323368B1 (de)
EP (1) EP1135357B1 (de)
JP (1) JP2002531429A (de)
KR (1) KR20010112223A (de)
CN (1) CN1329587A (de)
AT (1) ATE253037T1 (de)
AU (1) AU747431B2 (de)
BR (1) BR9915868A (de)
CA (1) CA2353549A1 (de)
DE (1) DE69912474D1 (de)
GB (1) GB9826540D0 (de)
WO (1) WO2000032554A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0010437D0 (en) * 2000-04-28 2000-06-14 Darwin Discovery Ltd Process
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
JP4357848B2 (ja) 2003-02-12 2009-11-04 株式会社リコー スクアリリウム金属キレート化合物および光記録媒体
GB0325051D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
EP1678151A1 (de) * 2003-10-27 2006-07-12 Smithkline Beecham Corporation Dynamisches kinetisches verfahren zur optischen trennung von diastereomeren zur herstellung von (+)-(2s, 3s)-2-(3-chlorphenyl)-3,5,5-trimethyl-2-morpholinol und salzen und solvaten davon
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
BRPI0516132A (pt) * 2004-10-07 2007-12-04 Vitae Pharmaceuticals Inc compostos, composição destes, método de antagonização de uma ou mais proteases aspárticas e método para tratar ou melhorar um distúrbio mediado por protease aspártica
TWI411607B (zh) * 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
EP1785412A1 (de) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Verfahren zur Rückgewinnung von Tramadol
CL2007002689A1 (es) * 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
US20090318501A1 (en) * 2006-09-18 2009-12-24 Baldwin John J Piperidine derivatives as renin inhibitors
EP2167609A1 (de) * 2007-06-20 2010-03-31 Vitae Pharmaceuticals, Inc. Renin-inhibitoren
CN101434552B (zh) * 2007-11-16 2012-05-23 江苏恒瑞医药股份有限公司 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分
AR077692A1 (es) * 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830934A (en) 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
DE19601745C1 (de) 1996-01-19 1997-10-09 Gruenenthal Gmbh Verfahren zur Racematspaltung von Tramadol

Also Published As

Publication number Publication date
AU1170800A (en) 2000-06-19
CN1329587A (zh) 2002-01-02
GB9826540D0 (en) 1999-01-27
WO2000032554A1 (en) 2000-06-08
JP2002531429A (ja) 2002-09-24
BR9915868A (pt) 2001-08-21
AU747431B2 (en) 2002-05-16
KR20010112223A (ko) 2001-12-20
EP1135357A1 (de) 2001-09-26
CA2353549A1 (en) 2000-06-08
EP1135357B1 (de) 2003-10-29
DE69912474D1 (de) 2003-12-04
US6323368B1 (en) 2001-11-27

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties