ATE247105T1 - Antipsychotische 4-(1h-indolyl-1-yl)-1- substituierte piperidine derivate - Google Patents

Antipsychotische 4-(1h-indolyl-1-yl)-1- substituierte piperidine derivate

Info

Publication number
ATE247105T1
ATE247105T1 AT96902258T AT96902258T ATE247105T1 AT E247105 T1 ATE247105 T1 AT E247105T1 AT 96902258 T AT96902258 T AT 96902258T AT 96902258 T AT96902258 T AT 96902258T AT E247105 T1 ATE247105 T1 AT E247105T1
Authority
AT
Austria
Prior art keywords
antipsychotic
indolyl
substituted piperidine
piperidine derivatives
derivatives
Prior art date
Application number
AT96902258T
Other languages
English (en)
Inventor
Jan Vandenberk
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE247105T1 publication Critical patent/ATE247105T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96902258T 1995-01-31 1996-01-23 Antipsychotische 4-(1h-indolyl-1-yl)-1- substituierte piperidine derivate ATE247105T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95200229 1995-01-31
PCT/EP1996/000363 WO1996023784A1 (en) 1995-01-31 1996-01-23 Antipsychotic 4-(1h-indolyl-1-yl)-1-substituted piperidine derivatives

Publications (1)

Publication Number Publication Date
ATE247105T1 true ATE247105T1 (de) 2003-08-15

Family

ID=8219983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96902258T ATE247105T1 (de) 1995-01-31 1996-01-23 Antipsychotische 4-(1h-indolyl-1-yl)-1- substituierte piperidine derivate

Country Status (21)

Country Link
US (1) US5919788A (de)
EP (1) EP0808313B1 (de)
JP (1) JP3980054B2 (de)
KR (1) KR100415391B1 (de)
CN (1) CN1152874C (de)
AR (1) AR002025A1 (de)
AT (1) ATE247105T1 (de)
AU (1) AU702931B2 (de)
BR (1) BR9606815A (de)
CA (1) CA2210913C (de)
DE (1) DE69629454T2 (de)
ES (1) ES2205015T3 (de)
FI (1) FI973164A0 (de)
IL (1) IL116930A (de)
MY (1) MY130950A (de)
NO (1) NO308537B1 (de)
NZ (1) NZ301264A (de)
PL (1) PL183291B1 (de)
TW (1) TW421649B (de)
WO (1) WO1996023784A1 (de)
ZA (1) ZA96702B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
TW528754B (en) * 1998-04-29 2003-04-21 Wyeth Corp Indolyl derivatibes as serotonergic agents
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
GB9810886D0 (en) * 1998-05-13 1998-07-22 Lilly Industries Ltd Pharmaceutical compounds
ES2546268T3 (es) * 2004-09-09 2015-09-22 Janssen Pharmaceutica Nv Preparación de 9-hidroxi-3-(2-hidroxietil)-2-metil-4H-pirido[1,2-a]pirimidin-4-ona y sus cristales
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
KR20090079189A (ko) * 2006-08-23 2009-07-21 테바 파마슈티컬 인더스트리즈 리미티드 Ｃｍｈｔｐ 및 이의 중간체의 합성 방법
US8071767B2 (en) * 2007-01-08 2011-12-06 Actavis Group Ptc Ehf Process for preparation of 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one hydrochloride
WO2008126886A1 (ja) * 2007-04-12 2008-10-23 Taisho Pharmaceutical Co., Ltd. インドール又はインドリン誘導体
WO2009010988A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
WO2012177708A1 (en) 2011-06-20 2012-12-27 Ratiopharm Gmbh Paliperidone oleate
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US5256659A (en) * 1989-01-09 1993-10-26 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
US5360807A (en) * 1990-07-19 1994-11-01 Janssen Pharmaceutica N.V. Substituted thiazolyl and substituted pyridinyl derivatives
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
IL116930A0 (en) 1996-05-14
PL321565A1 (en) 1997-12-08
AU702931B2 (en) 1999-03-11
ES2205015T3 (es) 2004-05-01
DE69629454T2 (de) 2004-06-17
CN1152874C (zh) 2004-06-09
MX9705821A (es) 1997-10-31
DE69629454D1 (en) 2003-09-18
PL183291B1 (pl) 2002-06-28
CA2210913A1 (en) 1996-08-08
TW421649B (en) 2001-02-11
KR19980701692A (ko) 1998-06-25
NZ301264A (en) 1998-07-28
JP3980054B2 (ja) 2007-09-19
AR002025A1 (es) 1998-01-07
EP0808313A1 (de) 1997-11-26
NO973508D0 (no) 1997-07-30
AU4664596A (en) 1996-08-21
FI973164A (fi) 1997-07-30
NO308537B1 (no) 2000-09-25
NO973508L (no) 1997-07-30
FI973164A0 (fi) 1997-07-30
JPH10512893A (ja) 1998-12-08
KR100415391B1 (ko) 2004-05-06
IL116930A (en) 2000-06-29
US5919788A (en) 1999-07-06
MY130950A (en) 2007-07-31
WO1996023784A1 (en) 1996-08-08
EP0808313B1 (de) 2003-08-13
CN1172482A (zh) 1998-02-04
CA2210913C (en) 2008-10-21
BR9606815A (pt) 1997-12-30
ZA96702B (en) 1997-07-30

Similar Documents

Publication Publication Date Title
ATE278695T1 (de) Piperidinderivate
DE69531331D1 (de) Phenylpiperidinderivate als neurokinin antagonists
DE69707782D1 (de) 4-Hydroxypiperidinderivate
MX209959B (es) 4-(3-heterociclil-1-benzoil)pirazoles
ATE353326T1 (de) Piperazin-derivate
DK0842143T5 (da) 2-(4-substituerede)-benzylamino-2-methyl-propanamid derivater
DK1131308T3 (da) Piperazin- og piperidinderivater
DK0842170T3 (da) Diphenylmethylen-piperidin-derivater
ATE247105T1 (de) Antipsychotische 4-(1h-indolyl-1-yl)-1- substituierte piperidine derivate
FI970110A (fi) Helico-bakteerin vastaisia heterosyklisiä atsolonijohdannaisia
DK0937458T3 (da) Pyrrolidin- og piperidinderivater
ATE315025T1 (de) Ethansulfonyl-piperidin-derivate
ATE205830T1 (de) 4-hydroxypiperidinderivate
NO992302L (no) Piperidin-derivater
ATE214063T1 (de) Heterocyclische substituierte pyrrolidinamid- derivate
NO20001778D0 (no) Substituerte piperidinderivater
TR199800596A3 (tr) Fenoksimetil piperidin türevleri
PT1131308E (pt) Novos compostos de piperazina e piperidina
BR1100219A (pt) Derivados de diidropiridina
DK1037892T3 (da) Piperidinderivater
DK0886645T3 (da) Nye 19-nor-pregnen-derivater

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties