ATE247104T1 - Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren - Google Patents

Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren

Info

Publication number
ATE247104T1
ATE247104T1 AT98952578T AT98952578T ATE247104T1 AT E247104 T1 ATE247104 T1 AT E247104T1 AT 98952578 T AT98952578 T AT 98952578T AT 98952578 T AT98952578 T AT 98952578T AT E247104 T1 ATE247104 T1 AT E247104T1
Authority
AT
Austria
Prior art keywords
azaring
heterocyclic group
ach receptor
nicotinic ach
receptor modulators
Prior art date
Application number
AT98952578T
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Simon Feldbaek Nielsen
Elsebet Ostergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE247104T1 publication Critical patent/ATE247104T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98952578T 1997-11-05 1998-11-05 Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren ATE247104T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK125997 1997-11-05
DKPA199800850 1998-06-26
PCT/DK1998/000478 WO1999024422A1 (en) 1997-11-05 1998-11-05 Azaring-ether derivatives and their use as nicotinic ach receptor modulators

Publications (1)

Publication Number Publication Date
ATE247104T1 true ATE247104T1 (de) 2003-08-15

Family

ID=26064766

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952578T ATE247104T1 (de) 1997-11-05 1998-11-05 Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren

Country Status (12)

Country Link
US (3) US6756386B1 (de)
EP (2) EP1357121A1 (de)
JP (1) JP2001522846A (de)
CN (1) CN1173972C (de)
AT (1) ATE247104T1 (de)
AU (1) AU747419B2 (de)
CA (1) CA2306477A1 (de)
DE (1) DE69817214T2 (de)
DK (1) DK1034174T3 (de)
HK (1) HK1032234A1 (de)
NZ (1) NZ503626A (de)
WO (1) WO1999024422A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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PT1107965E (pt) * 1998-08-25 2004-10-29 Ortho Mcneil Pharm Inc Eteres e tioeteres de piridilo como ligantes para receptores de acetilcolina nicotinica e as suas aplicacoes terapeuticas
US6303638B1 (en) 1999-08-06 2001-10-16 The Regents Of The University Of California Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
MXPA02002115A (es) * 1999-09-14 2002-10-31 Abbott Lab Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. .
DE10117686A1 (de) * 2001-04-09 2002-10-24 Celanese Ventures Gmbh Protonenleitende Membran und deren Verwendung
NZ533158A (en) * 2001-11-19 2006-09-29 Elan Pharm Inc 3,4-Disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines and piperazines
WO2004113297A2 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2529790A1 (en) * 2003-06-27 2005-01-27 Banyu Pharmaceutical Co., Ltd. Heteroaryloxy nitrogenous saturated heterocyclic derivative
CN101812056A (zh) * 2004-06-18 2010-08-25 神经研究公司 作为单胺神经递质再摄取抑制剂的新颖烷基取代的哌啶衍生物
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
US20070134169A1 (en) * 2005-12-11 2007-06-14 Rabinoff Michael D Methods for smoking cessation or alcohol cessation or other addiction cessation
JP2010523587A (ja) 2007-04-02 2010-07-15 パーキンソンズ インスティテュート 治療処置の副作用の低減のための方法および組成物
CA2974324A1 (en) 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
JP6654960B2 (ja) * 2016-01-15 2020-02-26 日本曹達株式会社 ルテニウム錯体の製造方法
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
JP7420797B2 (ja) 2018-05-29 2024-01-23 モーニングサイド ベンチャー インベストメンツ リミテッド 薬剤送達の方法及びシステム

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FR829845A (fr) 1936-12-04 1938-07-07 Delle Atel Const Electr Coupe-circuit à basse tension à élément fusible rechargeable
FR2306697A1 (fr) * 1975-04-10 1976-11-05 Sogeras Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants
US4379161A (en) * 1979-06-07 1983-04-05 Michel Thominet Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
DE3227741A1 (de) * 1982-07-24 1984-01-26 Hoechst Ag, 6230 Frankfurt 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung
US4592866A (en) * 1982-09-30 1986-06-03 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
ZA848275B (en) * 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4667031A (en) * 1985-10-15 1987-05-19 Ethyl Corporation Process for preparing oxazepinones
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
FR2640266B2 (fr) 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
DE4208254A1 (de) 1992-03-14 1993-09-16 Hoechst Ag Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
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JP2003297848A (ja) 2002-04-01 2003-10-17 Matsushita Electric Ind Co Ltd 半導体装置の製造方法

Also Published As

Publication number Publication date
JP2001522846A (ja) 2001-11-20
CA2306477A1 (en) 1999-05-20
DE69817214T2 (de) 2004-06-09
US20040242558A1 (en) 2004-12-02
EP1357121A1 (de) 2003-10-29
CN1173972C (zh) 2004-11-03
EP1034174B1 (de) 2003-08-13
US6756386B1 (en) 2004-06-29
EP1034174A1 (de) 2000-09-13
AU747419B2 (en) 2002-05-16
NZ503626A (en) 2002-05-31
AU1022499A (en) 1999-05-31
DK1034174T3 (da) 2003-09-22
HK1032234A1 (en) 2001-07-13
CN1278258A (zh) 2000-12-27
US20070161614A1 (en) 2007-07-12
WO1999024422A1 (en) 1999-05-20
DE69817214D1 (de) 2003-09-18
US7202237B2 (en) 2007-04-10

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