ATE246673T1 - Inhibitoren der produktion von s-cd23 und der secretion von tnf - Google Patents

Inhibitoren der produktion von s-cd23 und der secretion von tnf

Info

Publication number
ATE246673T1
ATE246673T1 AT97923064T AT97923064T ATE246673T1 AT E246673 T1 ATE246673 T1 AT E246673T1 AT 97923064 T AT97923064 T AT 97923064T AT 97923064 T AT97923064 T AT 97923064T AT E246673 T1 ATE246673 T1 AT E246673T1
Authority
AT
Austria
Prior art keywords
inhibitors
production
tnf secretion
tnf
secretion
Prior art date
Application number
AT97923064T
Other languages
English (en)
Inventor
Stuart Bailey
Derek Richard Buckle
Andrew Faller
David Glynn Smith
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE246673T1 publication Critical patent/ATE246673T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AT97923064T 1996-05-10 1997-05-06 Inhibitoren der produktion von s-cd23 und der secretion von tnf ATE246673T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609794.4A GB9609794D0 (en) 1996-05-10 1996-05-10 Novel compounds
PCT/EP1997/002433 WO1997043249A1 (en) 1996-05-10 1997-05-06 INHIBITORS OF THE PRODUCTION OF s-CD23 AND THE SECRETION OF TNF

Publications (1)

Publication Number Publication Date
ATE246673T1 true ATE246673T1 (de) 2003-08-15

Family

ID=10793494

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97923064T ATE246673T1 (de) 1996-05-10 1997-05-06 Inhibitoren der produktion von s-cd23 und der secretion von tnf

Country Status (21)

Country Link
US (1) US6235753B1 (de)
EP (1) EP0918747B1 (de)
JP (1) JP2000510473A (de)
KR (1) KR20000010892A (de)
AR (1) AR007060A1 (de)
AT (1) ATE246673T1 (de)
AU (1) AU2897397A (de)
BR (1) BR9709450A (de)
CA (1) CA2253590A1 (de)
CO (1) CO4990945A1 (de)
CZ (1) CZ363198A3 (de)
DE (1) DE69723984T2 (de)
ES (1) ES2205218T3 (de)
GB (1) GB9609794D0 (de)
IL (1) IL126860A0 (de)
NO (1) NO985214L (de)
NZ (1) NZ332628A (de)
PL (1) PL329855A1 (de)
TR (1) TR199802271T2 (de)
WO (1) WO1997043249A1 (de)
ZA (1) ZA973964B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020082200A1 (en) * 1994-07-13 2002-06-27 Smithkline Beecham P.1.C. Use of inhibitors of human S-CD23
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
JP2001522843A (ja) 1997-11-12 2001-11-20 ダーウィン・ディスカバリー・リミテッド Ｍｍｐおよびｔｎｆ抑制作用を有するヒドロキサム酸およびカルボン酸誘導体
GB9813451D0 (en) * 1998-06-22 1998-08-19 Smithkline Beecham Plc Novel compounds
GB9922825D0 (en) * 1999-09-25 1999-11-24 Smithkline Beecham Biolog Medical use
AU783504C (en) 1999-11-23 2006-08-03 Methylgene Inc. Inhibitors of histone deacetylase
GB9930754D0 (en) * 1999-12-29 2000-02-16 Smithkline Beecham Plc Novel compounds
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
CN103896796B (zh) * 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
WO2011068853A2 (en) 2009-12-01 2011-06-09 Boston Medical Center Corporation TREATMENT OF IgE-MEDIATED DISEASE
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
AU2014216417B2 (en) 2013-02-14 2016-05-12 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
AR102687A1 (es) * 2014-11-19 2017-03-15 Actelion Pharmaceuticals Ltd Derivados de benzotiazol antibacterianos
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215665D0 (en) 1992-07-23 1992-09-09 British Bio Technology Compounds
BR9506535A (pt) * 1994-01-20 1997-09-16 British Biotech Pharm Inibidores de metaloproteinases
GB9414157D0 (en) 1994-07-13 1994-08-31 Smithkline Beecham Plc Medical use
US5562917A (en) 1994-12-23 1996-10-08 Pentech Pharmaceuticals, Inc. Transdermal administration of apomorphine
DE19506492C2 (de) 1995-02-24 2003-05-08 Focke & Co Einrichtung zum Speichern von Zigaretten oder dergleichen
US5570079A (en) 1995-04-24 1996-10-29 Dockery; Devan Home security system for detecting an intrusion into a monitored area by an infrared detector

Also Published As

Publication number Publication date
KR20000010892A (ko) 2000-02-25
BR9709450A (pt) 1999-08-10
ZA973964B (en) 1998-11-09
CZ363198A3 (cs) 1999-06-16
NO985214L (no) 1998-12-01
AR007060A1 (es) 1999-10-13
IL126860A0 (en) 1999-09-22
NO985214D0 (no) 1998-11-09
JP2000510473A (ja) 2000-08-15
TR199802271T2 (xx) 2000-08-21
CO4990945A1 (es) 2000-12-26
NZ332628A (en) 2000-06-23
GB9609794D0 (en) 1996-07-17
DE69723984D1 (de) 2003-09-11
EP0918747A1 (de) 1999-06-02
EP0918747B1 (de) 2003-08-06
PL329855A1 (en) 1999-04-12
WO1997043249A1 (en) 1997-11-20
AU2897397A (en) 1997-12-05
DE69723984T2 (de) 2004-06-09
CA2253590A1 (en) 1997-11-20
ES2205218T3 (es) 2004-05-01
US6235753B1 (en) 2001-05-22

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