ATE239510T1 - Verfahren zur herstellung von ioversol - Google Patents

Verfahren zur herstellung von ioversol

Info

Publication number
ATE239510T1
ATE239510T1 AT96922444T AT96922444T ATE239510T1 AT E239510 T1 ATE239510 T1 AT E239510T1 AT 96922444 T AT96922444 T AT 96922444T AT 96922444 T AT96922444 T AT 96922444T AT E239510 T1 ATE239510 T1 AT E239510T1
Authority
AT
Austria
Prior art keywords
bis
reacting
produce
product
triiodoisopthalamide
Prior art date
Application number
AT96922444T
Other languages
English (en)
Inventor
Thomas Jeffrey Dunn
David H White
Mills Thomas Kneller
Michelle M Jones
Narciso Ocampo Doran Iii
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE239510T1 publication Critical patent/ATE239510T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96922444T 1995-06-07 1996-06-06 Verfahren zur herstellung von ioversol ATE239510T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/482,380 US5648536A (en) 1995-06-07 1995-06-07 Process for producing ioversol
PCT/US1996/010097 WO1996040286A1 (en) 1995-06-07 1996-06-06 Process for producing ioversol

Publications (1)

Publication Number Publication Date
ATE239510T1 true ATE239510T1 (de) 2003-05-15

Family

ID=23915832

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96922444T ATE239510T1 (de) 1995-06-07 1996-06-06 Verfahren zur herstellung von ioversol

Country Status (9)

Country Link
US (1) US5648536A (de)
EP (1) EP0839056B1 (de)
AT (1) ATE239510T1 (de)
DE (1) DE69628015T2 (de)
DK (1) DK0839056T3 (de)
ES (1) ES2198492T3 (de)
NO (1) NO323216B1 (de)
PT (1) PT839056E (de)
WO (1) WO1996040286A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596904B1 (en) * 1996-01-29 2003-07-22 Mallinc Krodt Inc Process for producing ioversol
GB9725010D0 (en) * 1997-11-26 1998-01-28 Nycomed Imaging As Process
ITMI20011706A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
US8518373B2 (en) * 2001-08-03 2013-08-27 Bracco Imaging Spa Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics
CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
WO2008104853A1 (en) * 2007-02-26 2008-09-04 Wockhardt Research Centre Processes for the preparation of pure ioversol
WO2011041275A1 (en) 2009-09-30 2011-04-07 Mallinckrodt Inc. Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system
WO2011041276A1 (en) 2009-09-30 2011-04-07 Mallinckrodt Inc. Reduction of fused bicyclic impurities in triiodinated x-ray contrast media
CN105669488A (zh) * 2016-01-11 2016-06-15 浙江海洲制药有限公司 X-ct造影剂含碘中间体母液的预处理及中间体回收方法
CN106336362B (zh) * 2016-08-24 2018-01-26 江苏恒瑞医药股份有限公司 一种碘佛醇的制备方法
CN106496058B (zh) * 2016-10-12 2018-11-16 浙江海洲制药有限公司 非离子型造影剂碘佛醇中间体的制备方法
CN106749323B (zh) * 2016-10-19 2018-10-09 江苏恒瑞医药股份有限公司 一种碘佛醇杂质的制备方法
CN107698456A (zh) * 2017-05-22 2018-02-16 成都丽璟科技有限公司 一种碘佛醇及其合成方法
KR102079983B1 (ko) * 2018-04-12 2020-02-21 (주)유케이케미팜 X선 조영제 이오버솔의 제조방법
CN110028418A (zh) * 2019-03-26 2019-07-19 大道隆达（北京）医药科技发展有限公司 一种碘佛醇的制备方法
CN110156623B (zh) * 2019-05-17 2022-05-27 浙江海洲制药有限公司 一种制备碘佛醇的方法
CN114213273A (zh) * 2021-12-15 2022-03-22 兄弟科技股份有限公司 一种碘美普尔的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
US5177261A (en) * 1991-07-22 1993-01-05 Mallinckrodt Medical, Inc. Synthesis of ioversol using chloroacetyl chloride
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride

Also Published As

Publication number Publication date
ES2198492T3 (es) 2004-02-01
EP0839056B1 (de) 2003-05-07
NO975743L (no) 1998-02-06
WO1996040286A1 (en) 1996-12-19
EP0839056A1 (de) 1998-05-06
DK0839056T3 (da) 2003-09-01
EP0839056A4 (de) 2000-09-13
DE69628015T2 (de) 2003-12-04
PT839056E (pt) 2003-09-30
US5648536A (en) 1997-07-15
NO323216B1 (no) 2007-01-29
NO975743D0 (no) 1997-12-05
DE69628015D1 (de) 2003-06-12

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