ATE238429T1 - Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern - Google Patents

Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern

Info

Publication number
ATE238429T1
ATE238429T1 AT97925690T AT97925690T ATE238429T1 AT E238429 T1 ATE238429 T1 AT E238429T1 AT 97925690 T AT97925690 T AT 97925690T AT 97925690 T AT97925690 T AT 97925690T AT E238429 T1 ATE238429 T1 AT E238429T1
Authority
AT
Austria
Prior art keywords
keto
gulonic acid
acid
gulonic
enzymatic process
Prior art date
Application number
AT97925690T
Other languages
English (en)
Inventor
John Clark Hubbs
Original Assignee
Eastman Chem Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Chem Co filed Critical Eastman Chem Co
Application granted granted Critical
Publication of ATE238429T1 publication Critical patent/ATE238429T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/847—Erwinia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97925690T 1996-05-17 1997-05-16 Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern ATE238429T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1787996P 1996-05-17 1996-05-17
US08/845,295 US5817490A (en) 1996-05-17 1997-04-25 Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
PCT/US1997/008668 WO1997043433A1 (en) 1996-05-17 1997-05-16 Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid

Publications (1)

Publication Number Publication Date
ATE238429T1 true ATE238429T1 (de) 2003-05-15

Family

ID=26690448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97925690T ATE238429T1 (de) 1996-05-17 1997-05-16 Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern

Country Status (10)

Country Link
US (4) US5817490A (de)
EP (1) EP0938582B1 (de)
JP (1) JP3759621B2 (de)
CN (3) CN1181206C (de)
AT (1) ATE238429T1 (de)
AU (1) AU3075697A (de)
BR (1) BR9709099A (de)
DE (1) DE69721292T2 (de)
MY (1) MY134224A (de)
WO (1) WO1997043433A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
DE60027218D1 (de) * 1999-01-18 2006-05-24 Dsm Ip Assets Bv Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
EP1026257B1 (de) * 1999-01-18 2006-04-12 DSM IP Assets B.V. Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
DE19938980A1 (de) 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
WO2002012528A2 (en) * 2000-08-04 2002-02-14 Genencor International, Inc. Enhanced 2-keto-l-gulonic acid production
AU781277B2 (en) * 2000-08-23 2005-05-12 Dsm Ip Assets B.V. Microbial production of L-ascorbic acid and D-erythorbic acid
EP1182262A1 (de) * 2000-08-23 2002-02-27 Roche Vitamins AG Mikrobielle Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
US6642035B2 (en) * 2001-01-26 2003-11-04 The Scripps Research Institute Synthesis of B-keto esters
US7229811B2 (en) * 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
US20070298474A1 (en) * 2001-08-03 2007-12-27 Manoj Kumar Enhanced 2-Keto-L-Gulonic acid production
CN1318600C (zh) * 2001-11-09 2007-05-30 Dsmip资产有限公司 生产l－抗坏血酸和d－异抗坏血酸的酶方法
EP1562965B1 (de) * 2002-11-11 2006-04-05 Basf Aktiengesellschaft VERFAHREN ZUR HERSTELLUNG VON 2-KETO-L-GULONSÄURE-C-4 C-10 /sb -ALKYLESTERN
US9279138B2 (en) * 2005-02-11 2016-03-08 Dsm Assets B.V. Vitamin C production in a microorganism, gluconobacter
AT502990A1 (de) * 2005-12-27 2007-07-15 Dsm Fine Chem Austria Gmbh Neues polypeptid mit esteraseaktivität, und rekombinante esterase sowie deren verwendung
MX2008012009A (es) * 2006-03-20 2008-10-03 Duramed Pharmaceuticals Inc Anillos intravaginales comprimidos y flexibles, metodos de elaboracion y utilizacion de los mismos y apaato de elaboracion de los mismos.
JP5438259B2 (ja) * 2006-04-13 2014-03-12 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 カンジダ・アンタークティカ由来リパーゼｂを細胞表層に提示する酵母
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
CN103459607A (zh) * 2011-03-30 2013-12-18 诺维信公司 酯化反应法
CN103344719B (zh) * 2013-06-27 2015-04-15 东北制药集团股份有限公司 一种可同时检测古龙酸、古龙酸甲酯、甲醇和乙醇的高效液相方法
CN111377543A (zh) * 2018-12-27 2020-07-07 南京百斯杰生物工程有限公司 脂肪酶在降低黄水酸度中的应用
KR102357426B1 (ko) * 2019-12-10 2022-01-28 건국대학교 산학협력단 신규 에스터 가수분해효소를 이용한 베타 아미노산의 효소적 생산방법

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Publication number Priority date Publication date Assignee Title
ES135896A1 (es) * 1933-10-25 1934-12-16 Hoffmann La Roche PROCEDIMIENTO PARA LA FABRICACIoN DEL áCIDO 2-CETO-1-GULoNICO
GB466548A (en) * 1935-11-26 1937-05-31 Tadeus Reichstein Process for the manufacture of laevo-ascorbic acid (vitamin-c)
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4595659A (en) * 1983-10-20 1986-06-17 Kraft, Inc. Fermentation production of ascorbic acid from L-galactonic substrate
US5008193A (en) * 1984-06-14 1991-04-16 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5001059A (en) * 1985-07-01 1991-03-19 Bio-Technical Resources, Inc. L-ascorbic acid production in microorganisms
CN86105960A (zh) * 1985-08-09 1987-05-13 鲁布里佐尔公司 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
US5079153A (en) * 1989-06-03 1992-01-07 Mitsubishi Rayon Co., Ltd. Process for the preparation of organic esters of ascorbic acid or erythorbic acid using ester hydralases in organic solvents containing 100-10,000 ppm of water
JPH04141093A (ja) * 1990-10-03 1992-05-14 Mitsubishi Rayon Co Ltd 有機酸エステルの製造法
JPH04335893A (ja) * 1991-05-07 1992-11-24 Mitsubishi Rayon Co Ltd 固定化酵素を用いるエステル合成方法
EP0514694B1 (de) * 1991-05-18 1997-07-23 Mitsubishi Rayon Co., Ltd Verfahren zur Herstellung von Ascorbinsäure-Estern oder Erythorbinsäure-Estern
JPH061783A (ja) * 1992-06-17 1994-01-11 Mitsubishi Rayon Co Ltd 有機酸エステルの製造法
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid

Also Published As

Publication number Publication date
DE69721292D1 (de) 2003-05-28
US5817490A (en) 1998-10-06
BR9709099A (pt) 1999-08-03
US6271006B1 (en) 2001-08-07
CN1181206C (zh) 2004-12-22
CN1225686A (zh) 1999-08-11
JP3759621B2 (ja) 2006-03-29
AU3075697A (en) 1997-12-05
CN1182250C (zh) 2004-12-29
CN1412316A (zh) 2003-04-23
DE69721292T2 (de) 2003-11-13
US6136575A (en) 2000-10-24
EP0938582B1 (de) 2003-04-23
CN1113100C (zh) 2003-07-02
WO1997043433A1 (en) 1997-11-20
MY134224A (en) 2007-11-30
JP2001505042A (ja) 2001-04-17
CN1412315A (zh) 2003-04-23
EP0938582A1 (de) 1999-09-01
US6022719A (en) 2000-02-08

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