ATE235520T1 - Phosphor ylide, herstellung und verwendung zu schwach-nukleophilen stark-basischen verbindungen - Google Patents

Phosphor ylide, herstellung und verwendung zu schwach-nukleophilen stark-basischen verbindungen

Info

Publication number
ATE235520T1
ATE235520T1 AT98925783T AT98925783T ATE235520T1 AT E235520 T1 ATE235520 T1 AT E235520T1 AT 98925783 T AT98925783 T AT 98925783T AT 98925783 T AT98925783 T AT 98925783T AT E235520 T1 ATE235520 T1 AT E235520T1
Authority
AT
Austria
Prior art keywords
ylides
nucleophils
phosphor
weak
strong
Prior art date
Application number
AT98925783T
Other languages
English (en)
Inventor
Guy Bertrand
Dennis Bigg
Jean-Bernard Cazaux
Stephanie Goumri
Olivier Guerret
Original Assignee
Sod Conseils Rech Applic
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic, Centre Nat Rech Scient filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of ATE235520T1 publication Critical patent/ATE235520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D227/08—Oxygen atoms
    • C07D227/087—One doubly-bound oxygen atom in position 2, e.g. lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/40—Introducing phosphorus atoms or phosphorus-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
AT98925783T 1997-05-26 1998-05-26 Phosphor ylide, herstellung und verwendung zu schwach-nukleophilen stark-basischen verbindungen ATE235520T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401142A EP0881235A1 (de) 1997-05-26 1997-05-26 Phosphor Ylide, Herstellung und Verwendung zu schwachnukleophilen starkbasischen Verbindungen
PCT/FR1998/001048 WO1998054229A1 (fr) 1997-05-26 1998-05-26 Utilisation d'ylures de phosphore en tant que bases fortes faiblement nucleophiles

Publications (1)

Publication Number Publication Date
ATE235520T1 true ATE235520T1 (de) 2003-04-15

Family

ID=8229758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98925783T ATE235520T1 (de) 1997-05-26 1998-05-26 Phosphor ylide, herstellung und verwendung zu schwach-nukleophilen stark-basischen verbindungen

Country Status (10)

Country Link
US (1) US6222032B1 (de)
EP (2) EP0881235A1 (de)
JP (1) JP2002504900A (de)
AT (1) ATE235520T1 (de)
AU (1) AU7776598A (de)
CA (1) CA2291345A1 (de)
DE (1) DE69812614D1 (de)
NO (1) NO995771L (de)
RU (1) RU2205842C2 (de)
WO (1) WO1998054229A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT984777E (pt) * 1997-05-12 2004-01-30 Ortho Mcneil Pharm Inc Piperazinas arilsubstituidas uteis no tratamento da hiperplasia benigna da prostata
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
FR2833602B1 (fr) * 2001-12-14 2004-03-12 Rhodia Chimie Sa Procede de preparation de polyorganosiloxanes (pos) par polycondensation/redistribution d'oligosiloxanes, en presence d'une superbase et superbases employees
KR20090045233A (ko) 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
EP2450039A1 (de) 2010-11-08 2012-05-09 PAION UK Ltd. Dosierschema zur Sedierung mit CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1003730B (de) * 1954-09-24 1957-03-07 Basf Ag Verfahren zur Herstellung von Yliden des Phosphors
US3274228A (en) * 1963-07-29 1966-09-20 Interchem Corp Triphenylphosphinemethylene compounds
GB1277736A (en) * 1968-09-30 1972-06-14 British Petroleum Co Catalyst support
US3681428A (en) * 1968-10-24 1972-08-01 Reynolds Tobacco Co R Synthesis of phosphorane compounds
GB1312611A (en) * 1969-05-09 1973-04-04 British Petroleum Co Catalyst supports
US3725365A (en) * 1971-04-08 1973-04-03 Dow Chemical Co Resins with phosphorane pendant groups and process for preparing same
US4043948A (en) * 1973-08-23 1977-08-23 The Dow Chemical Company Insoluble polyalkyl phosphonium salt resins having carbon-carbon crosslinked backbone
US3919126A (en) * 1973-08-23 1975-11-11 Dow Chemical Co Insoluble polyalkyl phosphonium salt resins having crosslinked backbone
US4092466A (en) * 1976-07-19 1978-05-30 Nasa Heat resistant polymers of oxidized styrylphosphine
CA1139318A (en) * 1979-12-03 1983-01-11 Dane K. Parker Process for preparing primary alkyl chlorides
GB2301104B (en) * 1995-05-23 1998-11-11 Ethyl Petroleum Additives Ltd Process for the preparation of polyalkene-substituted succinic acylating agents

Also Published As

Publication number Publication date
JP2002504900A (ja) 2002-02-12
CA2291345A1 (fr) 1998-12-03
AU7776598A (en) 1998-12-30
EP0881235A1 (de) 1998-12-02
WO1998054229A1 (fr) 1998-12-03
DE69812614D1 (de) 2003-04-30
EP0986585A1 (de) 2000-03-22
RU2205842C2 (ru) 2003-06-10
NO995771D0 (no) 1999-11-25
EP0986585B1 (de) 2003-03-26
US6222032B1 (en) 2001-04-24
NO995771L (no) 1999-11-25

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