ATE234626T1 - Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten - Google Patents
Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheitenInfo
- Publication number
- ATE234626T1 ATE234626T1 AT00946807T AT00946807T ATE234626T1 AT E234626 T1 ATE234626 T1 AT E234626T1 AT 00946807 T AT00946807 T AT 00946807T AT 00946807 T AT00946807 T AT 00946807T AT E234626 T1 ATE234626 T1 AT E234626T1
- Authority
- AT
- Austria
- Prior art keywords
- deoxynojirimycin
- treatment
- medication
- producing
- long chain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14556899P | 1999-07-26 | 1999-07-26 | |
PCT/US2000/016340 WO2001007078A1 (en) | 1999-07-26 | 2000-07-24 | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234626T1 true ATE234626T1 (de) | 2003-04-15 |
Family
ID=22513679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00946807T ATE234626T1 (de) | 1999-07-26 | 2000-07-24 | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
Country Status (8)
Country | Link |
---|---|
US (2) | US6495570B2 (de) |
EP (1) | EP1196190B1 (de) |
JP (1) | JP2003505430A (de) |
AT (1) | ATE234626T1 (de) |
AU (1) | AU6050600A (de) |
CA (1) | CA2378776A1 (de) |
DE (1) | DE60001745T2 (de) |
WO (1) | WO2001007078A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
GB9909064D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
AU2001269923A1 (en) * | 2000-06-19 | 2002-01-02 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
AU2007200154B2 (en) * | 2000-11-08 | 2009-01-29 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
JP4575156B2 (ja) * | 2002-07-17 | 2010-11-04 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
ES2393919T3 (es) * | 2002-07-17 | 2013-01-02 | Actelion Pharmaceuticals Ltd. | Derivados de PIPERIDINETRIOL como inhibidores de GLUCOSILCERAMIDA SINTASA |
WO2004037373A2 (en) * | 2002-10-21 | 2004-05-06 | The Scripps Research Institute | CHEMICAL CHAPERONES AND THEIR EFFECT UPON THE CELLULAR ACTIVITY OF β-GLUCOSIDASE |
CN102580066A (zh) * | 2003-01-31 | 2012-07-18 | 纽约大学西奈山医学院 | 酶和酶的活性部位特异性陪伴分子的组合 |
GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
GB0313677D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
AU2004289328B2 (en) * | 2003-11-12 | 2011-05-19 | Amicus Therapeutics, Inc. | Hydroxy piperidine derivatives to treat Gaucher disease |
US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
WO2006032039A2 (en) * | 2004-09-17 | 2006-03-23 | University Of Massachusetts | Compositions and their uses for lysosomal enzyme deficiencies |
EP2932982B1 (de) * | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | Verfahren zur Behandlung der Pompe-Krankheit mit 1-desoxynojirimycin und Derivaten |
ATE526991T1 (de) * | 2005-10-24 | 2011-10-15 | Univ Massachusetts | Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen |
JP5364382B2 (ja) | 2006-02-07 | 2013-12-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 遊離チオール部分を有するタンパク質の安定化された組成物 |
JP2011517279A (ja) * | 2007-10-29 | 2011-06-02 | ユニバーシティ オブ マサチューセッツ | 核酸(siRNA)送達用の酵母細胞壁粒子(YCWP)多層状ナノ粒子 |
WO2010056746A1 (en) * | 2008-11-11 | 2010-05-20 | Amicus Therapeutics, Inc. | Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease |
BRPI0923047B8 (pt) | 2008-12-16 | 2021-05-25 | Genzyme Corp | métodos para preparação de conjugados de proteínas- oligossacarídeos |
ES2579628T3 (es) | 2009-02-23 | 2016-08-12 | Emergent Virology Llc | Iminoazúcares y métodos de tratamiento de enfermedades virales |
WO2010099064A1 (en) * | 2009-02-24 | 2010-09-02 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
EP2440205B1 (de) | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminozucker zur verwendung in der behandlung von bunyaviralen und togaviralen erkrankungen |
CN105126086B (zh) | 2009-07-28 | 2019-05-14 | 夏尔人类遗传性治疗公司 | 用于治疗戈谢病的组合物和方法 |
CN102625801B (zh) * | 2009-09-04 | 2015-09-09 | 联合治疗公司 | 治疗痘病毒感染的方法 |
MX2012002486A (es) * | 2009-09-04 | 2012-09-07 | United Therapeutics Corp | Metodos para tratar infecciones ortomixovirales. |
EP2473046B1 (de) * | 2009-09-04 | 2014-10-22 | United Therapeutics Corporation | Iminozucker zur verwendung in der behandlung von filoviruserkrankungen |
WO2012001641A1 (en) * | 2010-06-30 | 2012-01-05 | Actelion Pharmaceuticals Ltd | Stable pharmaceutical compositions |
MX361231B (es) | 2012-03-02 | 2018-11-30 | Shire Human Genetic Therapies | Composiciones y usos de las mismas para tratar la enfermedad de gaucher tipo iii. |
KR20210062731A (ko) | 2012-03-07 | 2021-05-31 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물 |
WO2014179438A2 (en) * | 2013-05-02 | 2014-11-06 | The Chancellor, Masters And Scholars Of The University Of Oxford | Glycolipid inhibition using iminosugars |
CA2961762C (en) | 2014-09-30 | 2024-03-05 | Amicus Therapeutics, Inc. | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
SG11201804965SA (en) | 2015-12-30 | 2018-07-30 | Amicus Therapeutics Inc | Augmented acid alpha-glucosidase for the treatment of pompe disease |
KR20240001291A (ko) | 2016-03-30 | 2024-01-03 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 재조합 산 알파-글루코시다제를 포함하는 제형 |
JP7046003B2 (ja) | 2016-03-30 | 2022-04-01 | アミカス セラピューティックス インコーポレイテッド | 高m6p組換えタンパク質の選択方法 |
CN112294806B (zh) * | 2020-10-26 | 2022-11-29 | 西北农林科技大学 | 1-甲酰基-β-咔啉衍生物用于制备抗新城疫病毒药物的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3235111A1 (de) | 1982-09-22 | 1984-03-22 | Siemens AG, 1000 Berlin und 8000 München | Fernspeiseweiche fuer ein leitungsendgeraet eines analogen oder digitalen nachrichtenuebertragungssystems |
DE3507019A1 (de) | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
DE69331805T2 (de) | 1992-12-10 | 2002-11-28 | Enzon, Inc. | Glycolipid enzym-polymer konjugate |
US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
US5798366A (en) | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6291657B1 (en) * | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
EP0912179B1 (de) * | 1996-07-15 | 2006-04-12 | MacroZyme DNM B.V. | Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
-
2000
- 2000-07-24 JP JP2001511961A patent/JP2003505430A/ja active Pending
- 2000-07-24 DE DE60001745T patent/DE60001745T2/de not_active Expired - Fee Related
- 2000-07-24 EP EP00946807A patent/EP1196190B1/de not_active Expired - Lifetime
- 2000-07-24 CA CA002378776A patent/CA2378776A1/en not_active Abandoned
- 2000-07-24 AT AT00946807T patent/ATE234626T1/de not_active IP Right Cessation
- 2000-07-24 WO PCT/US2000/016340 patent/WO2001007078A1/en active IP Right Grant
- 2000-07-24 AU AU60506/00A patent/AU6050600A/en not_active Abandoned
-
2001
- 2001-05-17 US US09/859,928 patent/US6495570B2/en not_active Expired - Lifetime
-
2002
- 2002-01-22 US US10/054,802 patent/US6696059B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1196190B1 (de) | 2003-03-19 |
US20020127213A1 (en) | 2002-09-12 |
CA2378776A1 (en) | 2001-02-01 |
AU6050600A (en) | 2001-02-13 |
DE60001745T2 (de) | 2004-03-04 |
JP2003505430A (ja) | 2003-02-12 |
DE60001745D1 (de) | 2003-04-24 |
US6495570B2 (en) | 2002-12-17 |
WO2001007078A1 (en) | 2001-02-01 |
EP1196190A1 (de) | 2002-04-17 |
US6696059B2 (en) | 2004-02-24 |
US20010044453A1 (en) | 2001-11-22 |
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