ATE22692T1 - Phosphonamidate verbindungen. - Google Patents
Phosphonamidate verbindungen.Info
- Publication number
- ATE22692T1 ATE22692T1 AT82401459T AT82401459T ATE22692T1 AT E22692 T1 ATE22692 T1 AT E22692T1 AT 82401459 T AT82401459 T AT 82401459T AT 82401459 T AT82401459 T AT 82401459T AT E22692 T1 ATE22692 T1 AT E22692T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphonamidate
- phosphonamidate compounds
- compounds
- useful
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/44—Amides thereof
- C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1806—Stationary reactors having moving elements inside resulting in a turbulent flow of the reactants, such as in centrifugal-type reactors, or having a high Reynolds-number
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28967181A | 1981-08-03 | 1981-08-03 | |
EP82401459A EP0071544B1 (de) | 1981-08-03 | 1982-08-03 | Phosphonamidate Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE22692T1 true ATE22692T1 (de) | 1986-10-15 |
Family
ID=23112565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT82401459T ATE22692T1 (de) | 1981-08-03 | 1982-08-03 | Phosphonamidate verbindungen. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0071544B1 (de) |
JP (1) | JPS5838294A (de) |
AT (1) | ATE22692T1 (de) |
CA (1) | CA1276392C (de) |
DE (1) | DE3273628D1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0075895A3 (de) * | 1981-09-25 | 1984-05-02 | The Wellcome Foundation Limited | Pharmazeutisch wirksame Amide und ihre Herstellung, Formulierung und deren Verwendung |
JPS58217319A (ja) * | 1982-06-11 | 1983-12-17 | Idemitsu Petrochem Co Ltd | 非極性合成樹脂フイルムの溶着方法 |
NZ225757A (en) * | 1987-09-10 | 1989-12-21 | Squibb & Sons Inc | Phosphonate and phosphonamide endopeptidase inhibitors |
US4849525A (en) * | 1987-09-21 | 1989-07-18 | E. R. Squibb & Sons, Inc. | Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
IT1276161B1 (it) * | 1995-11-23 | 1997-10-27 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
AU2006332945C1 (en) | 2005-12-23 | 2013-02-28 | Wyeth | Modified lysine-mimetic compounds |
EP2074087A2 (de) | 2006-12-21 | 2009-07-01 | Wyeth | Synthese von pyrrolidinverbindungen |
DK3618847T3 (da) | 2017-05-05 | 2021-05-25 | Boston Medical Ct Corp | GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316896A (en) * | 1978-09-07 | 1982-02-23 | Merck & Co., Inc. | Aminoacid derivatives as antihypertensives |
US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
-
1982
- 1982-08-03 EP EP82401459A patent/EP0071544B1/de not_active Expired
- 1982-08-03 DE DE8282401459T patent/DE3273628D1/de not_active Expired
- 1982-08-03 JP JP57136206A patent/JPS5838294A/ja active Granted
- 1982-08-03 CA CA000408601A patent/CA1276392C/en not_active Expired - Lifetime
- 1982-08-03 AT AT82401459T patent/ATE22692T1/de active
Also Published As
Publication number | Publication date |
---|---|
DE3273628D1 (en) | 1986-11-13 |
CA1276392C (en) | 1990-11-13 |
EP0071544A1 (de) | 1983-02-09 |
JPH0354116B2 (de) | 1991-08-19 |
JPS5838294A (ja) | 1983-03-05 |
EP0071544B1 (de) | 1986-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0097534A3 (en) | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives | |
ES8802045A1 (es) | Procedimiento para la produccion de tiazoles | |
DE3881970T2 (de) | Heterocyclische Verbindungen. | |
DE3576339D1 (de) | Heterocyclische verbindungen. | |
DE3580221D1 (de) | Orale zusammensetzungen. | |
IE823045L (en) | Amino acid derivatives containing phosphorus | |
NO885337D0 (no) | D-cykloserin og dets promedikamenter for bedring av hukommelse. | |
ES2122145T3 (es) | Fosfiniloximetil-cetonas peptidicas como inhibidores de la enzima convertida de la interleuquina-1 beta. | |
ATE22692T1 (de) | Phosphonamidate verbindungen. | |
ATE94537T1 (de) | Arylpiperazinylalkylenphenylheterocyclische verbindungen. | |
IT1183423B (it) | Amplificatore video di uscita, non suscettibile di saturazione | |
ES546866A0 (es) | Procedimiento de preparar derivados antihipertensivos | |
IT8521235A0 (it) | Composti farmacologicamente attivi. | |
DE3578424D1 (de) | Quino-benzothiazin-antibakterielle verbindungen. | |
DE3768393D1 (de) | Alicyclische verbindungen. | |
IT8519903A0 (it) | Farmaceutiche che li contengono. composti ad attivita'antiaggregante piastrinica, procedimento per la loro preparazione e composizioni | |
IT8419413A0 (it) | Composti imidazopiridinici farmacologicamente attivi. | |
EP0127090A3 (de) | Inhibitoren für Angiotensin umwandelnde Enzyme | |
IT1197892B (it) | Composizioni farmaceutiche ad attivita' cicatrizzante | |
ATE49960T1 (de) | Heterocyclische verbindungen. | |
SU1432991A1 (ru) | 4-Метил-5-(4-метилфениламино)-1,2,3-триазол, обладающий противовоспалительной активностью | |
IT8620847A0 (it) | Composti ad attivita'anti-ipertenisiva. | |
IT8323995A0 (it) | Composto ad attivita'antiipertensiva. | |
IT8422446A0 (it) | Composti farmacologicamente attivi. | |
SU1441755A1 (ru) | 1-фосфонометил-1,3,4-гексагидротриазин-2-тион-5-он, обладающий гербицидной активностью |