ATE224705T1 - Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküle - Google Patents
Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküleInfo
- Publication number
- ATE224705T1 ATE224705T1 AT97929716T AT97929716T ATE224705T1 AT E224705 T1 ATE224705 T1 AT E224705T1 AT 97929716 T AT97929716 T AT 97929716T AT 97929716 T AT97929716 T AT 97929716T AT E224705 T1 ATE224705 T1 AT E224705T1
- Authority
- AT
- Austria
- Prior art keywords
- colipides
- amphiphils
- compositions containing
- therapeutic molecules
- containing cationic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/657,238 US5935936A (en) | 1996-06-03 | 1996-06-03 | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
PCT/US1997/009142 WO1997046223A1 (en) | 1996-06-03 | 1997-05-30 | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE224705T1 true ATE224705T1 (de) | 2002-10-15 |
Family
ID=24636394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97929716T ATE224705T1 (de) | 1996-06-03 | 1997-05-30 | Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküle |
Country Status (8)
Country | Link |
---|---|
US (1) | US5935936A (de) |
EP (1) | EP0845981B1 (de) |
JP (1) | JPH11511757A (de) |
AT (1) | ATE224705T1 (de) |
CA (1) | CA2228444A1 (de) |
DE (1) | DE69715786T2 (de) |
ES (1) | ES2187791T3 (de) |
WO (1) | WO1997046223A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5674908A (en) * | 1993-12-20 | 1997-10-07 | Life Technologies, Inc. | Highly packed polycationic ammonium, sulfonium and phosphonium lipids |
US6989434B1 (en) | 1994-02-11 | 2006-01-24 | Invitrogen Corporation | Reagents for intracellular delivery of macromolecules |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
WO1998044909A1 (en) * | 1997-04-04 | 1998-10-15 | Valentis Inc. | Improved methods of delivery using cationic lipids and helper lipids |
US6235310B1 (en) | 1997-04-04 | 2001-05-22 | Valentis, Inc. | Methods of delivery using cationic lipids and helper lipids |
EP1027033B1 (de) | 1997-05-14 | 2009-07-22 | The University Of British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
WO2000027795A1 (en) | 1998-11-12 | 2000-05-18 | Invitrogen Corporation | Transfection reagents |
US6521431B1 (en) * | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
IL131074A0 (en) | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
US6677445B1 (en) * | 1999-08-27 | 2004-01-13 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
ATE388226T1 (de) * | 1999-08-27 | 2008-03-15 | Novartis Vaccines & Diagnostic | Chimerische antisense-oligonukleotide und zelltransfektions-zusammensetzungen davon |
WO2001081408A2 (en) * | 2000-04-21 | 2001-11-01 | New England Medical Center | G-protein coupled receptor (gpcr) agonists and antagonists and methods of activating and inhibiting gpcr using the same |
US7696168B2 (en) * | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
US20020095135A1 (en) * | 2000-06-19 | 2002-07-18 | David Meeker | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
PT1404867E (pt) * | 2000-12-23 | 2008-06-05 | Novartis Vaccines & Diagnostic | Método de pesquisa da transfecção de oligonucleótidos |
IL140844A0 (en) * | 2001-01-10 | 2002-02-10 | Polygene Ltd | Cationic polysaccharide compositions |
US20030096414A1 (en) * | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
WO2002100317A2 (en) | 2001-05-25 | 2002-12-19 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
MXPA04003761A (es) * | 2001-10-22 | 2005-04-08 | Sterrenbeld Biotechnologie North America Inc | Lipidos cationicos anfofilos derivados del colesterol. |
DE60223950T2 (de) * | 2002-03-26 | 2008-11-13 | Council Of Scientific & Industrial Research | Katonische amphiphile zur intrazellulären verabreichung therapeutischer moleküle, zusammensetzung, verfahren sowie deren verwendung |
US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
AU2003266014B2 (en) * | 2002-05-06 | 2009-05-14 | Alnylam Pharmaceuticals, Inc. | Methods for delivery of nucleic acids |
US7183263B2 (en) | 2002-07-17 | 2007-02-27 | University Of Utah Research Foundation | Linear polyethylenimine-sterol conjugates for gene delivery |
EP1540004A4 (de) * | 2002-07-31 | 2007-10-03 | Nucleonics Inc | Doppelstrang-rna-strukturen und -konstrukte sowie verfahren zur erzeugung und verwendung davon |
EP1578193A4 (de) * | 2002-12-23 | 2011-06-15 | Vical Inc | Gefriertrocknungsverfahren für nukleinsäure-/blockcopolymer-/kationtensid-komplexe |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
EP1804835B9 (de) | 2004-09-13 | 2010-09-29 | Genzyme Corporation | Multimere konstrukte |
JP2008519039A (ja) * | 2004-11-04 | 2008-06-05 | ニュー イングランド メデカル センター ホスピタルズ インク | Gタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法 |
US7939505B2 (en) | 2007-05-04 | 2011-05-10 | Marina Biotech, Inc. | Amino acid lipids and uses thereof |
EP4212541A1 (de) | 2008-12-16 | 2023-07-19 | Genzyme Corporation | Oligosaccharid-protein-konjugate und zwischenprodukte davon |
ES2734973T3 (es) | 2009-12-01 | 2019-12-13 | Translate Bio Inc | Administración de ARNm para el aumento de proteínas y enzimas en enfermedades genéticas humanas |
EP2717893B1 (de) | 2011-06-08 | 2019-05-08 | Translate Bio, Inc. | Lipidnanoteilchenzusammensetzungen und verfahren zur mrna-freisetzung |
WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
EP3467108B1 (de) | 2013-03-14 | 2024-05-22 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
IL290953B2 (en) | 2013-03-14 | 2024-01-01 | Ethris Gmbh | CFTR mRNA Assemblies and Related Methods and Uses |
MX2016005237A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Terapia de acido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa. |
EP3060258A1 (de) | 2013-10-22 | 2016-08-31 | Shire Human Genetic Therapies, Inc. | Mrna-therapie für phenylketonurie |
WO2015093588A1 (ja) * | 2013-12-21 | 2015-06-25 | Ktnバイオテック株式会社 | 抗癌剤 |
CN117402871A (zh) | 2014-04-25 | 2024-01-16 | 川斯勒佰尔公司 | 信使rna的纯化方法 |
EP3169310A1 (de) | 2014-07-15 | 2017-05-24 | Life Technologies Corporation | Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen |
EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
CA3063531A1 (en) | 2017-05-16 | 2018-11-22 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
JPS617292A (ja) * | 1984-06-20 | 1986-01-13 | Japan Atom Energy Res Inst | 制癌剤を結合させたエストラサイト系化合物を製造する方法 |
US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4971803A (en) * | 1985-04-08 | 1990-11-20 | California Institute Of Technology | Lamellar vesicles formed of cholesterol derivatives |
EP0316345A1 (de) * | 1986-07-28 | 1989-05-24 | Liposome Technology, Inc. | Liposome mit verbesserter bindung an schleimgewebe |
US5043164A (en) * | 1989-01-17 | 1991-08-27 | The University Of Tennessee Research Corporation | Blood-stable, cholesterol-free liposomes |
FR2645866B1 (fr) * | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
US5004737A (en) * | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
CA2037478A1 (en) * | 1990-03-05 | 1991-09-06 | Richard Gregory | Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
EP0490379A3 (de) * | 1990-12-13 | 1992-06-24 | BERLIN-CHEMIE Aktiengesellschaft | Diaminosäurederivate und pharmazeutische Zusammensetzungen |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US5705655A (en) * | 1992-12-17 | 1998-01-06 | Megabios Corporation | Amphiphilic nitrogen containing imidazolinium derivative compounds and uses |
CA2157594A1 (en) * | 1993-03-10 | 1994-09-15 | Leah L. Frye | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
WO1995002698A1 (en) * | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
CA2176715A1 (en) * | 1993-11-24 | 1995-06-01 | Timothy D. Heath | Amphiphilic derivatives of guanidine |
EP0730568A4 (de) * | 1993-11-24 | 1997-02-19 | Megabios Corp | Amphile piperazin-derivate |
DE69430321T2 (de) * | 1993-12-20 | 2003-09-25 | Biotech Tools S.A., Bruessel/Bruxelles | Verbindung geeignet zur einführung von wenigstens einem molekül in eine zelle |
WO1995021812A1 (en) * | 1994-02-14 | 1995-08-17 | Indiana University Foundation | Aminophospholipid compositions and uses thereof |
WO1995024222A1 (en) * | 1994-03-07 | 1995-09-14 | University Of Medicine & Dentistry Of New Jersey | Cyclic polycationic polymer-oligonucleotide conjugates and methods for preparing same |
US5670347A (en) * | 1994-05-11 | 1997-09-23 | Amba Biosciences Llc | Peptide-mediated gene transfer |
US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
EP0748332B1 (de) * | 1994-12-28 | 1999-11-10 | Max-Delbrück-Centrum Für Molekulare Medizin | Neues cholesterolderivat für den liposomalen gentransfer |
FR2744453B1 (fr) * | 1996-02-05 | 1998-07-10 | Transgene Sa | Composes lipopolyamines, compositions pharmaceutiques en comprenant, vecteurs de transfert d'acide nucleique et procede de preparation |
-
1996
- 1996-06-03 US US08/657,238 patent/US5935936A/en not_active Expired - Fee Related
-
1997
- 1997-05-30 AT AT97929716T patent/ATE224705T1/de not_active IP Right Cessation
- 1997-05-30 WO PCT/US1997/009142 patent/WO1997046223A1/en active IP Right Grant
- 1997-05-30 DE DE69715786T patent/DE69715786T2/de not_active Expired - Fee Related
- 1997-05-30 CA CA002228444A patent/CA2228444A1/en not_active Abandoned
- 1997-05-30 ES ES97929716T patent/ES2187791T3/es not_active Expired - Lifetime
- 1997-05-30 EP EP97929716A patent/EP0845981B1/de not_active Expired - Lifetime
- 1997-05-30 JP JP10500678A patent/JPH11511757A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5935936A (en) | 1999-08-10 |
ES2187791T3 (es) | 2003-06-16 |
JPH11511757A (ja) | 1999-10-12 |
DE69715786T2 (de) | 2003-05-28 |
WO1997046223A1 (en) | 1997-12-11 |
CA2228444A1 (en) | 1997-12-11 |
DE69715786D1 (de) | 2002-10-31 |
EP0845981B1 (de) | 2002-09-25 |
EP0845981A1 (de) | 1998-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |