ATE219142T1 - METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE - Google Patents

METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE

Info

Publication number
ATE219142T1
ATE219142T1 AT96905024T AT96905024T ATE219142T1 AT E219142 T1 ATE219142 T1 AT E219142T1 AT 96905024 T AT96905024 T AT 96905024T AT 96905024 T AT96905024 T AT 96905024T AT E219142 T1 ATE219142 T1 AT E219142T1
Authority
AT
Austria
Prior art keywords
proline
hydroxy
producing trans
producing
hydroxylases
Prior art date
Application number
AT96905024T
Other languages
German (de)
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE219142T1 publication Critical patent/ATE219142T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to industrial methods for producing trans-4-hydroxy-L-proline which is useful as a starting compound for medicines and an additive to foods, genes which code for L-proline 4-hydroxylases and which are useful for the above-mentioned process, recombinant DNA containing the gene, transformants containing the recombinant DNA, methods for producing L-proline 4-hydroxylases using the transformants and the enzyme.
AT96905024T 1995-03-07 1996-03-07 METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE ATE219142T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4698895 1995-03-07
PCT/JP1996/000559 WO1996027669A1 (en) 1995-03-07 1996-03-07 Process for producing trans-4-hydroxy-l-proline

Publications (1)

Publication Number Publication Date
ATE219142T1 true ATE219142T1 (en) 2002-06-15

Family

ID=12762595

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96905024T ATE219142T1 (en) 1995-03-07 1996-03-07 METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE

Country Status (10)

Country Link
EP (1) EP0759472B1 (en)
JP (1) JP3440100B2 (en)
KR (1) KR100460579B1 (en)
CN (1) CN1132938C (en)
AT (1) ATE219142T1 (en)
CA (1) CA2189682C (en)
DE (1) DE69621714T2 (en)
ES (1) ES2176441T3 (en)
HK (1) HK1000712A1 (en)
WO (1) WO1996027669A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2143786B1 (en) 2007-04-06 2014-12-10 Kyowa Hakko Bio Co., Ltd. Method for producing dipeptide
US8623619B2 (en) 2009-02-09 2014-01-07 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acid
CN101864436B (en) * 2010-05-26 2012-05-23 东北农业大学 Biosynthesis method of isotope 13C labeling 4-oxyproline
CN103275998B (en) * 2013-06-14 2015-03-04 河北博伦特药业有限公司 Gene segment with coded and highly-active trans-4-hydroxyl-L-prolyl hydroxylase and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374542A (en) * 1991-08-26 1994-12-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing 4-hydroxy-L-proline
JPH05236980A (en) * 1991-12-17 1993-09-17 Sankyo Co Ltd Production of trans-4-hydroxy-l-proline
KR100356926B1 (en) * 1993-09-07 2003-01-10 교와 핫꼬 고교 가부시끼가이샤 Process for producing trans-4-hydroxy-l-proline
JPH07126297A (en) * 1993-11-05 1995-05-16 Sagami Chem Res Center Calmodulin-fused protein

Also Published As

Publication number Publication date
EP0759472A1 (en) 1997-02-26
CN1150821A (en) 1997-05-28
DE69621714T2 (en) 2003-01-30
KR970702921A (en) 1997-06-10
ES2176441T3 (en) 2002-12-01
CA2189682C (en) 2001-12-04
EP0759472A4 (en) 1999-05-19
HK1000712A1 (en) 2002-09-27
JP3440100B2 (en) 2003-08-25
CN1132938C (en) 2003-12-31
CA2189682A1 (en) 1996-09-12
DE69621714D1 (en) 2002-07-18
KR100460579B1 (en) 2005-01-15
WO1996027669A1 (en) 1996-09-12
EP0759472B1 (en) 2002-06-12

Similar Documents

Publication Publication Date Title
DE69632887D1 (en) Process for the appropriate production of transglutaminase by recombinant DNA
DE60039080D1 (en) Process for the purification of proanthocyanidin oligomers
DE69939901D1 (en) METHOD AND MATERIALS FOR THE PRODUCTION OF GLUCOSAMINE
ATE273310T1 (en) METHOD FOR PRODUCING ALKOXYSILANES
DE69834452D1 (en) Process for the preparation of optically active compounds
ATE277999T1 (en) METHOD FOR PRODUCING AMINE REACTION PRODUCT PARTICLES
ATE103637T1 (en) PROCESS FOR THE PRODUCTION OF FOCUS RESTRICTION ENDONUCLEASE AND METHYLASE.
ATE219142T1 (en) METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE
ATE118817T1 (en) METHOD FOR PRODUCING XBAI RESTRICTION ENDONUCLEASE AND METHYLASE.
ATE261981T1 (en) METHOD FOR PRODUCING ALKYLPHOSPHONY ACIDS
ATE220419T1 (en) METHOD FOR PRODUCING CIS-3-HYDROXY-L-PROLINE
ATE103329T1 (en) PROCESS FOR PRODUCTION OF HGIAIRRESTRICTION ENDONUCLEASE AND METHYLASE.
ATE138934T1 (en) METHOD FOR THE ENZYMATIC PRODUCTION OF MACROLACTONE
ATE411978T1 (en) METHOD FOR PRODUCING ALPHA-AMINOKETONES
ATE360087T1 (en) METHOD FOR THE RACEMAT CLEAVING OF ARYLAKYLCARBOXIC ACID ESTERS
ATE235461T1 (en) METHOD FOR PRODUCING 3-CYANO-2,4-DIHALOGEN-5-FLUORO-BENZOIC ACIDS
ATE233732T1 (en) METHOD FOR PRODUCING AZETIDINE-2-CARBOXYLIC ACID AND INTERMEDIATE PRODUCTS THEREOF
DE68913055D1 (en) Process for the production of AseI restriction endonuclease and methylase.
ATE190653T1 (en) METHOD FOR PRODUCING RECOMBINANT AND SYNTHETIC PEPTIDES AND THEIR USE
ATE191508T1 (en) MICROBIOLOGICAL PROCESS FOR THE PRODUCTION OF 1-UNSATURATED, 17-BETA-CARBOXYSUBSTITUTED 3-OXO-4-AZAANDROSTAN-3-ONENES
ATA221292A (en) NEW METHOD FOR PRODUCING 3-VINYLCEPHALOSPORINE COMPOUNDS
ATE118816T1 (en) METHOD FOR PRODUCING ACCI-RESTRICTION ENDONUCLEASE AND METHYLASE.
DE69606679D1 (en) Process for the production of aryl and vinyl nitriles
DE59510916D1 (en) Improved, induction-free process for the genetic engineering of glutarylamidase

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee