ATE219142T1 - METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE - Google Patents
METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINEInfo
- Publication number
- ATE219142T1 ATE219142T1 AT96905024T AT96905024T ATE219142T1 AT E219142 T1 ATE219142 T1 AT E219142T1 AT 96905024 T AT96905024 T AT 96905024T AT 96905024 T AT96905024 T AT 96905024T AT E219142 T1 ATE219142 T1 AT E219142T1
- Authority
- AT
- Austria
- Prior art keywords
- proline
- hydroxy
- producing trans
- producing
- hydroxylases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
The present invention relates to industrial methods for producing trans-4-hydroxy-L-proline which is useful as a starting compound for medicines and an additive to foods, genes which code for L-proline 4-hydroxylases and which are useful for the above-mentioned process, recombinant DNA containing the gene, transformants containing the recombinant DNA, methods for producing L-proline 4-hydroxylases using the transformants and the enzyme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4698895 | 1995-03-07 | ||
PCT/JP1996/000559 WO1996027669A1 (en) | 1995-03-07 | 1996-03-07 | Process for producing trans-4-hydroxy-l-proline |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE219142T1 true ATE219142T1 (en) | 2002-06-15 |
Family
ID=12762595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96905024T ATE219142T1 (en) | 1995-03-07 | 1996-03-07 | METHOD FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0759472B1 (en) |
JP (1) | JP3440100B2 (en) |
KR (1) | KR100460579B1 (en) |
CN (1) | CN1132938C (en) |
AT (1) | ATE219142T1 (en) |
CA (1) | CA2189682C (en) |
DE (1) | DE69621714T2 (en) |
ES (1) | ES2176441T3 (en) |
HK (1) | HK1000712A1 (en) |
WO (1) | WO1996027669A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2143786B1 (en) | 2007-04-06 | 2014-12-10 | Kyowa Hakko Bio Co., Ltd. | Method for producing dipeptide |
US8623619B2 (en) | 2009-02-09 | 2014-01-07 | Kyowa Hakko Bio Co., Ltd. | Process for producing L-amino acid |
CN101864436B (en) * | 2010-05-26 | 2012-05-23 | 东北农业大学 | Biosynthesis method of isotope 13C labeling 4-oxyproline |
CN103275998B (en) * | 2013-06-14 | 2015-03-04 | 河北博伦特药业有限公司 | Gene segment with coded and highly-active trans-4-hydroxyl-L-prolyl hydroxylase and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374542A (en) * | 1991-08-26 | 1994-12-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing 4-hydroxy-L-proline |
JPH05236980A (en) * | 1991-12-17 | 1993-09-17 | Sankyo Co Ltd | Production of trans-4-hydroxy-l-proline |
KR100356926B1 (en) * | 1993-09-07 | 2003-01-10 | 교와 핫꼬 고교 가부시끼가이샤 | Process for producing trans-4-hydroxy-l-proline |
JPH07126297A (en) * | 1993-11-05 | 1995-05-16 | Sagami Chem Res Center | Calmodulin-fused protein |
-
1996
- 1996-03-07 KR KR1019960706294A patent/KR100460579B1/en not_active IP Right Cessation
- 1996-03-07 WO PCT/JP1996/000559 patent/WO1996027669A1/en active IP Right Grant
- 1996-03-07 CN CN96190335A patent/CN1132938C/en not_active Expired - Lifetime
- 1996-03-07 CA CA002189682A patent/CA2189682C/en not_active Expired - Lifetime
- 1996-03-07 AT AT96905024T patent/ATE219142T1/en not_active IP Right Cessation
- 1996-03-07 ES ES96905024T patent/ES2176441T3/en not_active Expired - Lifetime
- 1996-03-07 JP JP52677096A patent/JP3440100B2/en not_active Expired - Lifetime
- 1996-03-07 EP EP96905024A patent/EP0759472B1/en not_active Expired - Lifetime
- 1996-03-07 DE DE69621714T patent/DE69621714T2/en not_active Expired - Lifetime
-
1997
- 1997-11-28 HK HK97102278A patent/HK1000712A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0759472A1 (en) | 1997-02-26 |
CN1150821A (en) | 1997-05-28 |
DE69621714T2 (en) | 2003-01-30 |
KR970702921A (en) | 1997-06-10 |
ES2176441T3 (en) | 2002-12-01 |
CA2189682C (en) | 2001-12-04 |
EP0759472A4 (en) | 1999-05-19 |
HK1000712A1 (en) | 2002-09-27 |
JP3440100B2 (en) | 2003-08-25 |
CN1132938C (en) | 2003-12-31 |
CA2189682A1 (en) | 1996-09-12 |
DE69621714D1 (en) | 2002-07-18 |
KR100460579B1 (en) | 2005-01-15 |
WO1996027669A1 (en) | 1996-09-12 |
EP0759472B1 (en) | 2002-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |