ATE215949T1 - Hydroisochinolinderivate - Google Patents

Hydroisochinolinderivate

Info

Publication number
ATE215949T1
ATE215949T1 AT94924764T AT94924764T ATE215949T1 AT E215949 T1 ATE215949 T1 AT E215949T1 AT 94924764 T AT94924764 T AT 94924764T AT 94924764 T AT94924764 T AT 94924764T AT E215949 T1 ATE215949 T1 AT E215949T1
Authority
AT
Austria
Prior art keywords
pct
derivatives
sec
nitrogen
zero
Prior art date
Application number
AT94924764T
Other languages
English (en)
Inventor
Giulio Dondio
Silvano Ronzoni
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT93MI001788A external-priority patent/IT1265043B1/it
Priority claimed from ITMI940202A external-priority patent/IT1274008B/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Application granted granted Critical
Publication of ATE215949T1 publication Critical patent/ATE215949T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT94924764T 1993-08-06 1994-07-14 Hydroisochinolinderivate ATE215949T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT93MI001788A IT1265043B1 (it) 1993-08-06 1993-08-06 Derivati di idroisochinolina
ITMI940202A IT1274008B (it) 1994-02-04 1994-02-04 Derivati di idroisochinolina
PCT/EP1994/002325 WO1995004734A1 (en) 1993-08-06 1994-07-14 Hydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE215949T1 true ATE215949T1 (de) 2002-04-15

Family

ID=26331034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94924764T ATE215949T1 (de) 1993-08-06 1994-07-14 Hydroisochinolinderivate

Country Status (11)

Country Link
US (1) US5731322A (de)
EP (1) EP0712402B1 (de)
JP (1) JPH09505030A (de)
CN (1) CN1043641C (de)
AT (1) ATE215949T1 (de)
AU (1) AU690576B2 (de)
CA (1) CA2168853A1 (de)
DE (1) DE69430373T2 (de)
ES (1) ES2173921T3 (de)
NZ (1) NZ271338A (de)
WO (1) WO1995004734A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AU2002346994B2 (en) 2001-10-15 2007-09-06 Janssen Pharmaceutica N.V. Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
CN100549004C (zh) 2003-10-01 2009-10-14 阿得罗公司 螺环杂环衍生物及其应用方法
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP3827747A1 (de) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharmainformatiksystem
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
AU2007294968A1 (en) 2006-09-12 2008-03-20 Adolor Corporation Use of N-containing spirocompounds for the enhancement of cognitive function
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
US7645801B2 (en) * 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
IL295075A (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
AU2012204232A1 (en) 2011-01-07 2013-06-27 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
EP3560493B1 (de) 2013-11-25 2021-03-31 Corcept Therapeutics Incorporated Oktahydro-kondensierte azadecalin-glucocorticoid-rezeptor-modulatoren
UA127409C2 (uk) 2017-03-31 2023-08-16 Корцепт Терап'Ютікс, Інк. Модулятори глюкокортикоїдного рецептора для лікування раку шийки матки
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
MX2021007322A (es) 2018-12-19 2021-07-07 Corcept Therapeutics Inc Formulaciones farmaceuticas que contienen relacorilant, un compuesto de azadecalina fusionado con heteroaril-cetona.
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
SG11202108964YA (en) 2019-02-22 2021-09-29 Corcept Therapeutics Inc Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
CN110330465B (zh) * 2019-06-28 2021-05-11 深圳市三启药物开发有限公司 腙酰胺类衍生物及其在制备防治脱发药物中的应用
AU2020400061A1 (en) 2019-12-11 2022-04-14 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260762A (en) * 1979-09-10 1981-04-07 Hoffmann-La Roche Inc. Octahydro-1H-pyrrolo[2,3-g]isoquinolines
ES2173866T3 (es) * 1991-07-05 2002-11-01 Glaxosmithkline Spa Derivados de hidroisoquinolina.

Also Published As

Publication number Publication date
JPH09505030A (ja) 1997-05-20
CN1132510A (zh) 1996-10-02
CA2168853A1 (en) 1995-02-16
WO1995004734A1 (en) 1995-02-16
AU690576B2 (en) 1998-04-30
AU7493794A (en) 1995-02-28
NZ271338A (en) 1998-06-26
DE69430373D1 (de) 2002-05-16
US5731322A (en) 1998-03-24
EP0712402B1 (de) 2002-04-10
DE69430373T2 (de) 2002-12-12
ES2173921T3 (es) 2002-11-01
CN1043641C (zh) 1999-06-16
EP0712402A1 (de) 1996-05-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties