ATE214093T1 - METHOD FOR THE CONTINUOUS ENZYMATIC PROCESS OF HYDROPHOBIC PRODUCTS AND APPARATUS SUITABLE THEREFOR - Google Patents

METHOD FOR THE CONTINUOUS ENZYMATIC PROCESS OF HYDROPHOBIC PRODUCTS AND APPARATUS SUITABLE THEREFOR

Info

Publication number
ATE214093T1
ATE214093T1 AT95935328T AT95935328T ATE214093T1 AT E214093 T1 ATE214093 T1 AT E214093T1 AT 95935328 T AT95935328 T AT 95935328T AT 95935328 T AT95935328 T AT 95935328T AT E214093 T1 ATE214093 T1 AT E214093T1
Authority
AT
Austria
Prior art keywords
product
apparatus suitable
enzymatic process
hydrophobic products
suitable therefor
Prior art date
Application number
AT95935328T
Other languages
German (de)
Inventor
Wolfgang Kruse
Udo Kragl
Christian Wandrey
Original Assignee
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh filed Critical Forschungszentrum Juelich Gmbh
Application granted granted Critical
Publication of ATE214093T1 publication Critical patent/ATE214093T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

In a process for the continuous enzyme-catalyticzed enzymatic production of hydrophobic products in an aqueous solution of a reaction mixture, the product is extracted from the product containing reaction mixture by way of a product-permeable microporous membrane into an organic solvent and the product-depleted reaction mixture is recycled.
AT95935328T 1994-10-11 1995-10-07 METHOD FOR THE CONTINUOUS ENZYMATIC PROCESS OF HYDROPHOBIC PRODUCTS AND APPARATUS SUITABLE THEREFOR ATE214093T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4436149A DE4436149A1 (en) 1994-10-11 1994-10-11 Process for the continuous enzyme catalytic extraction of hydrophobic products
PCT/DE1995/001399 WO1996011256A1 (en) 1994-10-11 1995-10-07 Process for the continuous enzymatic extraction of hydrophobic products and device suitable therefor

Publications (1)

Publication Number Publication Date
ATE214093T1 true ATE214093T1 (en) 2002-03-15

Family

ID=6530382

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95935328T ATE214093T1 (en) 1994-10-11 1995-10-07 METHOD FOR THE CONTINUOUS ENZYMATIC PROCESS OF HYDROPHOBIC PRODUCTS AND APPARATUS SUITABLE THEREFOR

Country Status (8)

Country Link
US (1) US5795750A (en)
EP (1) EP0785986B1 (en)
JP (1) JPH10506790A (en)
AT (1) ATE214093T1 (en)
AU (1) AU701750B2 (en)
DE (2) DE4436149A1 (en)
DK (1) DK0785986T3 (en)
WO (1) WO1996011256A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19913862C2 (en) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Process for the biocatalyzed conversion of poorly water-soluble substances
US6774243B2 (en) 1999-08-24 2004-08-10 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6355807B1 (en) 1999-08-24 2002-03-12 Agouron Pharmaceuticals, Inc. Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US20030064429A1 (en) * 1999-08-24 2003-04-03 Agouron Pharmaceuticals, Inc. Efficient methods for the preparation of rhinovirus protease inhibitors, key intermediates and a continuous membrane reactor useful for preparing the same
US6475382B2 (en) 2000-12-19 2002-11-05 Co2 Solution Inc. Treatment unit for treating a fluid and method thereof
EP1359948A1 (en) * 2001-01-30 2003-11-12 IsoTis S.A. A method for applying a bioactive coating on a medical device
CA2353307A1 (en) * 2001-07-13 2003-01-13 Carmen Parent Device and procedure for processing gaseous effluents
DE10208007A1 (en) * 2002-02-26 2003-09-18 Forschungszentrum Juelich Gmbh Process for the production of alcohols from substrates by means of oxidoreductases, two-phase system comprising an aqueous phase and an organic phase and device for carrying out the process
CA2405635A1 (en) * 2002-09-27 2004-03-27 C02 Solution Inc. A process and a plant for the production of useful carbonated species and for the recycling of carbon dioxide emissions from power plants
DE10313972A1 (en) * 2003-03-27 2004-10-21 Degussa Ag Coupled cofactor-dependent enzymatic reaction system
DE10313971A1 (en) * 2003-03-27 2004-10-21 Degussa Ag Coupled cofactor-dependent enzymatic reaction system
DE102004007029A1 (en) * 2004-02-12 2005-09-08 Consortium für elektrochemische Industrie GmbH Process for the enantioselective reduction of keto compounds by enzymes
US20060177913A1 (en) * 2005-02-08 2006-08-10 Consortium Fur Elektrochemische Industrie Gmbh Process for enantioselective enzymatic reduction of keto compounds
CN109943482B (en) * 2019-03-06 2022-03-29 江苏惠利生物科技有限公司 Method for preparing ethyl r-4-chloro-3-hydroxybutyrate by coupling extraction of enzyme membrane reactor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915802A (en) * 1974-08-19 1975-10-28 Upjohn Co Dialysis process and apparatus
JPS60232085A (en) * 1984-04-28 1985-11-18 Kanegafuchi Chem Ind Co Ltd Method for germ-free filtration
US4795704A (en) * 1985-10-11 1989-01-03 Sepracor, Inc. Multiphase asymmetric membrane reactor systems
US4939090A (en) * 1986-05-06 1990-07-03 United States Of America As Represented By The Secretary Of Agriculture Method of reacting immiscible liquids with a catalyst-impregnated membrane
US5336601A (en) * 1986-08-18 1994-08-09 The Coca-Cola Company Enzymatic membrane method for the snythesis and separation of peptides
EP0273679A2 (en) * 1986-12-29 1988-07-06 EASTMAN KODAK COMPANY (a New Jersey corporation) Improved method for effecting enzymatic reactions and an enzymatic reactor useful therein
US4956289A (en) * 1987-03-16 1990-09-11 Brunswick Corporation Thin film membrane enzyme reactor and method of using same
US5057421A (en) * 1987-03-16 1991-10-15 Brunswick Corporation Thin film membrane enzyme/coemzyme reactor and method of using same
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DE3850652T2 (en) * 1987-09-07 1994-10-27 Hitachi Ltd CELL GROWING METHOD AND DEVICE.
US5080795A (en) * 1990-05-23 1992-01-14 Research Corporation Technologies, Inc. Supported chiral liquid membrane for the separation of enantiomers
DE4016971A1 (en) * 1990-05-25 1991-11-28 Forschungszentrum Juelich Gmbh METHOD AND DEVICE FOR SEPARATING AMMONIUM FROM AQUEOUS LIQUIDS
DE4041896C1 (en) * 1990-12-27 1991-12-19 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De Enzymatic synthesis of organic cpds. e.g. for producing cyanohydrin(s) - by feeding reactants and enzyme catalyst to compartment contg. permeable membrane to allow diffusion

Also Published As

Publication number Publication date
DE59510095D1 (en) 2002-04-11
AU701750B2 (en) 1999-02-04
JPH10506790A (en) 1998-07-07
WO1996011256A1 (en) 1996-04-18
EP0785986A1 (en) 1997-07-30
DK0785986T3 (en) 2002-06-24
AU3740295A (en) 1996-05-02
EP0785986B1 (en) 2002-03-06
DE4436149A1 (en) 1996-04-18
US5795750A (en) 1998-08-18

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