ATE209204T1 - Piperidinderivate. - Google Patents

Piperidinderivate.

Info

Publication number: ATE209204T1
Authority: AT; Austria
Prior art keywords: piperidine derivatives; represents hydrogen; lower alkyl; antagonism; vomiting
Prior art date: 1995-03-27

Application number

AT96907664T

Other languages

English (en)

Inventor

Yoshihiro Tanoue

Koichi Beppu

Akira Okayama

Osami Sakamoto

Original Assignee

Hisamitsu Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-27

Filing date

1996-03-27

Publication date

2001-12-15

1996-03-27 Application filed by Hisamitsu Pharmaceutical Co filed Critical Hisamitsu Pharmaceutical Co

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209204T1 publication Critical patent/ATE209204T1/de

Links

NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000003053 piperidines Chemical class 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000008673 vomiting Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT96907664T 1995-03-27 1996-03-27 Piperidinderivate. ATE209204T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9315095		1995-03-27
PCT/JP1996/000796 WO1996030367A1 (fr)	1995-03-27	1996-03-27	Derives de piperidine

Publications (1)

Publication Number	Publication Date
ATE209204T1 true ATE209204T1 (de)	2001-12-15

Family

ID=14074519

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96907664T ATE209204T1 (de)	1995-03-27	1996-03-27	Piperidinderivate.

Country Status (9)

Country	Link
US (1)	US5886011A (de)
EP (1)	EP0826684B1 (de)
JP (1)	JP3992733B2 (de)
KR (1)	KR19980703354A (de)
AT (1)	ATE209204T1 (de)
AU (1)	AU696948B2 (de)
CA (1)	CA2216701A1 (de)
DE (1)	DE69617226T2 (de)
WO (1)	WO1996030367A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW426667B (en) *	1997-11-19	2001-03-21	Pfizer	Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
AR018376A1 (es) *	1998-05-26	2001-11-14	Novartis Ag	Composiciones farmaceuticas que se pueden dispersar de una manera espontanea y el uso de las mismas para la manufactura de un medicamento
ATE308898T1 (de) *	1998-09-09	2005-11-15	Q P Corp	Brechreizunterdrueckende nahrungsmittel
AP1396A (en) *	1999-05-21	2005-04-19	Pfizer Prod Inc	1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives.
WO2001025233A1 (fr) *	1999-10-07	2001-04-12	Hisamitsu Pharmaceutical Co., Inc.	Derives de piperidine
US7235257B1 (en) *	1999-12-14	2007-06-26	Rohto Pharmaceutical Co., Ltd.	Drugs for relieving hemicrania comprising 1-menthol and essential oils
US7728155B2 (en)	2003-10-24	2010-06-01	Wyeth Llc	Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
US20070218143A1 (en) *	2006-03-20	2007-09-20	Chong Mok T M	Topical preparation
ES2672099T3 (es)	2011-07-04	2018-06-12	Irbm - Science Park S.P.A.	Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP3758688B1 (de)	2018-02-26	2024-03-27	Ospedale San Raffaele S.r.l.	Nk-1-antagonisten zur verwendung bei der behandlung von augenschmerzen
WO2021180885A1 (en)	2020-03-11	2021-09-16	Ospedale San Raffaele S.R.L.	Treatment of stem cell deficiency

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5232929A (en) *	1990-11-28	1993-08-03	Pfizer Inc.	3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
JPH0794440B2 (ja) *	1991-03-26	1995-10-11	フアイザー・インコーポレイテツド	置換ピペリジンの立体選択的製造
CA2150123C (en) *	1992-12-10	2004-12-07	Harry R. Howard	Aminomethylene substituted non-aromatic heterocycles
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis

1996
- 1996-03-27 CA CA002216701A patent/CA2216701A1/en not_active Abandoned
- 1996-03-27 US US08/913,824 patent/US5886011A/en not_active Expired - Fee Related
- 1996-03-27 DE DE69617226T patent/DE69617226T2/de not_active Expired - Fee Related
- 1996-03-27 AU AU51202/96A patent/AU696948B2/en not_active Ceased
- 1996-03-27 WO PCT/JP1996/000796 patent/WO1996030367A1/ja not_active Application Discontinuation
- 1996-03-27 JP JP52916796A patent/JP3992733B2/ja not_active Expired - Fee Related
- 1996-03-27 KR KR1019970706759A patent/KR19980703354A/ko not_active Application Discontinuation
- 1996-03-27 EP EP96907664A patent/EP0826684B1/de not_active Expired - Lifetime
- 1996-03-27 AT AT96907664T patent/ATE209204T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0826684A4 (de)	1998-07-08
CA2216701A1 (en)	1996-10-03
EP0826684A1 (de)	1998-03-04
DE69617226T2 (de)	2002-07-25
AU5120296A (en)	1996-10-16
KR19980703354A (ko)	1998-10-15
EP0826684B1 (de)	2001-11-21
WO1996030367A1 (fr)	1996-10-03
JP3992733B2 (ja)	2007-10-17
DE69617226D1 (de)	2002-01-03
US5886011A (en)	1999-03-23
AU696948B2 (en)	1998-09-24

Legal Events

Date	Code	Title	Description
2002-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
CA2124680A1 (en)	1993-06-10	Piperazine derivatives as 5-ht1a antagonists
FI943142A (fi)	1994-12-31	Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
AU9281198A (en)	1999-04-23	Benzofuran derivatives
DE69122941D1 (de)	1996-12-05	Piperazinderivate
ES2123873T3 (es)	1999-01-16	Pirrolocarbazol.
ATE209204T1 (de)	2001-12-15	Piperidinderivate.
DK0916651T3 (da)	2003-12-01	Phenylalkylcarboxylsyrederivater
DE69621469D1 (de)	2002-07-04	Phenylpiperidin-derivate
DE69810960D1 (de)	2003-02-27	2-phenoxyanilin-derivate
DE69926776D1 (de)	2005-09-22	Quinalozinon-derivate
AU4370489A (en)	1990-05-03	The use of oxidized polyamines, especially nn'-bis-(3- propionaldehyde)-1-4-diaminobutane (sperminedialdehyde) as immunosuppressive agents
DE60103732D1 (de)	2004-07-15	Pyrimidinderivate mit antitumor-wirkung