ATE208380T1 - Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern - Google Patents

Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern

Info

Publication number
ATE208380T1
ATE208380T1 AT99302979T AT99302979T ATE208380T1 AT E208380 T1 ATE208380 T1 AT E208380T1 AT 99302979 T AT99302979 T AT 99302979T AT 99302979 T AT99302979 T AT 99302979T AT E208380 T1 ATE208380 T1 AT E208380T1
Authority
AT
Austria
Prior art keywords
chlorophenyl
phenylmethyl
piperazinyl
ethoxy
producing
Prior art date
Application number
AT99302979T
Other languages
English (en)
Inventor
Ori Lerman
Erez Gal
Joseph Kaspi
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Application granted granted Critical
Publication of ATE208380T1 publication Critical patent/ATE208380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99302979T 1998-04-23 1999-04-16 Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern ATE208380T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12419598A IL124195A (en) 1998-04-23 1998-04-23 Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid

Publications (1)

Publication Number Publication Date
ATE208380T1 true ATE208380T1 (de) 2001-11-15

Family

ID=11071431

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99302979T ATE208380T1 (de) 1998-04-23 1999-04-16 Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern

Country Status (14)

Country Link
US (1) US6100400A (de)
EP (1) EP0952153B1 (de)
KR (1) KR19990081747A (de)
AT (1) ATE208380T1 (de)
CA (1) CA2269394C (de)
CZ (1) CZ141599A3 (de)
DE (1) DE69900424T2 (de)
DK (1) DK0952153T3 (de)
ES (1) ES2165223T3 (de)
HU (1) HUP9901337A3 (de)
IL (1) IL124195A (de)
PL (1) PL332521A1 (de)
SI (1) SI9900098A (de)
SK (1) SK282710B6 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239277B1 (en) * 1999-10-20 2001-05-29 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
KR100503443B1 (ko) * 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
KR100669824B1 (ko) 2005-04-18 2007-01-16 경동제약 주식회사 (-)-2-[2-[4-[(4-클로로페닐)페닐메틸]-1-피페라지닐]에톡시]-아세트산의 제조방법
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
WO2009022327A2 (en) * 2007-08-15 2009-02-19 Chemagis Ltd. Novel process for preparing highly pure levocetirizine and salts thereof
CN101928263A (zh) * 2010-07-06 2010-12-29 四川大学 一种制备盐酸乙氟利嗪的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4233963A1 (de) * 1992-10-08 1994-04-14 Schwabe Willmar Gmbh & Co Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.

Also Published As

Publication number Publication date
EP0952153B1 (de) 2001-11-07
HUP9901337A2 (hu) 2000-04-28
HU9901337D0 (en) 1999-07-28
KR19990081747A (ko) 1999-11-15
DE69900424T2 (de) 2002-07-18
HUP9901337A3 (en) 2001-02-28
DK0952153T3 (da) 2003-04-14
CA2269394C (en) 2003-12-09
SK282710B6 (sk) 2002-11-06
SI9900098A (sl) 1999-12-31
EP0952153A2 (de) 1999-10-27
CA2269394A1 (en) 1999-10-23
US6100400A (en) 2000-08-08
CZ141599A3 (cs) 1999-11-17
PL332521A1 (en) 1999-10-25
DE69900424D1 (de) 2001-12-13
SK52299A3 (en) 2000-02-14
ES2165223T3 (es) 2002-03-01
IL124195A (en) 2000-08-31
EP0952153A3 (de) 2000-01-12

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee