ATE204022T1 - Verfahren zur herstellung/sekretion eines proteins durch einen transformiertenschimmelpilz unter verwendung von expressions-/sekretions- regulationsregionenaus aspergillus - Google Patents
Verfahren zur herstellung/sekretion eines proteins durch einen transformiertenschimmelpilz unter verwendung von expressions-/sekretions- regulationsregionenaus aspergillusInfo
- Publication number
- ATE204022T1 ATE204022T1 AT93900048T AT93900048T ATE204022T1 AT E204022 T1 ATE204022 T1 AT E204022T1 AT 93900048 T AT93900048 T AT 93900048T AT 93900048 T AT93900048 T AT 93900048T AT E204022 T1 ATE204022 T1 AT E204022T1
- Authority
- AT
- Austria
- Prior art keywords
- secretion
- expression
- aspergillus
- production
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01136—Glucuronoarabinoxylan endo-1,4-beta-xylanase (3.2.1.136), i.e. feraxanase or feraxan-endoxylanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
- C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01032—Xylan endo-1,3-beta-xylosidase (3.2.1.32), i.e. endo-1-3-beta-xylanase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9102051 | 1991-12-09 | ||
| PCT/EP1992/002896 WO1993012237A1 (en) | 1991-12-09 | 1992-12-09 | Process for producing/secreting a protein by a transformed mould using expression/secretion regulating regions derived from an aspergillus endoxylanase ii gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204022T1 true ATE204022T1 (de) | 2001-08-15 |
Family
ID=19860011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93900048T ATE204022T1 (de) | 1991-12-09 | 1992-12-09 | Verfahren zur herstellung/sekretion eines proteins durch einen transformiertenschimmelpilz unter verwendung von expressions-/sekretions- regulationsregionenaus aspergillus |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5705358A (de) |
| EP (1) | EP0672149B1 (de) |
| JP (1) | JP2866739B2 (de) |
| AT (1) | ATE204022T1 (de) |
| AU (1) | AU664223B2 (de) |
| CA (1) | CA2123416C (de) |
| DE (1) | DE69231995T2 (de) |
| DK (1) | DK0672149T3 (de) |
| ES (1) | ES2159519T3 (de) |
| FI (1) | FI111958B (de) |
| WO (1) | WO1993012237A1 (de) |
| ZA (1) | ZA929539B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US5610046A (en) * | 1992-12-24 | 1997-03-11 | Gist-Brocades, N.V. | Cloning and expression of xylanase B |
| DE69433499T2 (de) * | 1993-03-10 | 2004-12-02 | Novozymes A/S | Enzyme mit xylanaseaktivität aus aspergillus aculeatus |
| US5811381A (en) * | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
| US7883872B2 (en) * | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| EP0870835A1 (de) * | 1997-04-07 | 1998-10-14 | Unilever N.V. | Transformation von Schimmeln durch Agrobacterium, insbesondere von der Gattung Aspergillus |
| US6255115B1 (en) | 1997-04-07 | 2001-07-03 | Unilever Patent Holdings Bv | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus |
| US6015703A (en) * | 1998-03-10 | 2000-01-18 | Iogen Corporation | Genetic constructs and genetically modified microbes for enhanced production of beta-glucosidase |
| CA2345356C (en) * | 1998-10-06 | 2012-10-02 | Mark Aaron Emalfarb | Transformation system in the field of filamentous fungal hosts |
| CN101857867A (zh) * | 2003-11-06 | 2010-10-13 | 金克克国际有限公司 | 蛋白酶抑制剂及其变异体在丝状真菌中的表达 |
| WO2007087503A1 (en) | 2006-01-23 | 2007-08-02 | Novozymes A/S | Polypeptides having lipase activity and polynucleotides encoding same |
| DK2059590T3 (en) * | 2006-07-14 | 2015-02-23 | Novozymes Inc | Methods for preparation of secreted polypeptides having biological activity |
| US9862956B2 (en) | 2006-12-10 | 2018-01-09 | Danisco Us Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
| WO2008073914A2 (en) | 2006-12-10 | 2008-06-19 | Dyadic International Inc. | Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi |
| WO2009033071A2 (en) * | 2007-09-07 | 2009-03-12 | Dyadic International, Inc. | Novel fungal enzymes |
| KR20200026878A (ko) | 2017-06-06 | 2020-03-11 | 지머젠 인코포레이티드 | 균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼 |
| JP2021526799A (ja) | 2018-06-06 | 2021-10-11 | ザイマージェン インコーポレイテッド | 発酵および産生中の真菌の形態を制御するためのシグナル伝達に関与する遺伝子の操作 |
| US11479779B2 (en) | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341226C (en) * | 1988-08-16 | 2001-05-01 | Wim Van Hartingsveldt | Gene replacement as a tool for the construction of aspergillus strains |
| US5171672A (en) * | 1989-08-31 | 1992-12-15 | Allelix Biopharmaceuticals Inc. | Recombinant DNA system for Aspergillus |
| EP0421919A3 (en) * | 1989-09-02 | 1992-04-15 | Ciba-Geigy Ag | Polygalacturonase encoding fungal expression system |
| JP2995770B2 (ja) * | 1989-12-15 | 1999-12-27 | 吉富製薬株式会社 | 異種蛋白質の製造方法 |
| FI103206B (fi) * | 1990-01-29 | 1999-05-14 | Novartis Ag | Uusi ilmentämisjärjestelmä sieniä varten |
| NL9001388A (nl) * | 1990-06-19 | 1992-01-16 | Unilever Nv | Recombinant dna, cel die daarvan afgeleid dna bevat, enzym waarvoor het recombinant dna codeert en toepassingen daarvan. |
| IE912582A1 (en) * | 1990-07-24 | 1992-01-29 | Gist Brocades Nv | Cloning and expression of xylanase genes from fungal origin |
-
1992
- 1992-12-09 ES ES93900048T patent/ES2159519T3/es not_active Expired - Lifetime
- 1992-12-09 US US08/244,686 patent/US5705358A/en not_active Expired - Fee Related
- 1992-12-09 JP JP5510625A patent/JP2866739B2/ja not_active Expired - Fee Related
- 1992-12-09 CA CA002123416A patent/CA2123416C/en not_active Expired - Fee Related
- 1992-12-09 WO PCT/EP1992/002896 patent/WO1993012237A1/en active IP Right Grant
- 1992-12-09 DK DK93900048T patent/DK0672149T3/da active
- 1992-12-09 EP EP93900048A patent/EP0672149B1/de not_active Expired - Lifetime
- 1992-12-09 AU AU31583/93A patent/AU664223B2/en not_active Ceased
- 1992-12-09 DE DE69231995T patent/DE69231995T2/de not_active Expired - Fee Related
- 1992-12-09 AT AT93900048T patent/ATE204022T1/de not_active IP Right Cessation
- 1992-12-09 ZA ZA929539A patent/ZA929539B/xx unknown
-
1994
- 1994-06-08 FI FI942691A patent/FI111958B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI942691A0 (fi) | 1994-06-08 |
| EP0672149B1 (de) | 2001-08-08 |
| US5705358A (en) | 1998-01-06 |
| CA2123416A1 (en) | 1993-06-24 |
| DE69231995T2 (de) | 2002-04-04 |
| AU664223B2 (en) | 1995-11-09 |
| AU3158393A (en) | 1993-07-19 |
| DK0672149T3 (da) | 2001-11-05 |
| DE69231995D1 (de) | 2001-09-13 |
| ZA929539B (en) | 1994-06-09 |
| FI942691A (fi) | 1994-06-08 |
| CA2123416C (en) | 2003-05-20 |
| ES2159519T3 (es) | 2001-10-16 |
| EP0672149A1 (de) | 1995-09-20 |
| FI111958B (fi) | 2003-10-15 |
| WO1993012237A1 (en) | 1993-06-24 |
| JP2866739B2 (ja) | 1999-03-08 |
| JPH07501453A (ja) | 1995-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |