ATE203249T1 - Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie - Google Patents

Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Info

Publication number
ATE203249T1
ATE203249T1 AT93902233T AT93902233T ATE203249T1 AT E203249 T1 ATE203249 T1 AT E203249T1 AT 93902233 T AT93902233 T AT 93902233T AT 93902233 T AT93902233 T AT 93902233T AT E203249 T1 ATE203249 T1 AT E203249T1
Authority
AT
Austria
Prior art keywords
pct
obtaining
anion exchange
exchange chromatography
von willebrand
Prior art date
Application number
AT93902233T
Other languages
English (en)
Inventor
Monika Stadler
Horst Schwinn
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6451895&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE203249(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma Ag filed Critical Octapharma Ag
Application granted granted Critical
Publication of ATE203249T1 publication Critical patent/ATE203249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT93902233T 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie ATE203249T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4204694A DE4204694C3 (de) 1992-02-01 1992-02-01 Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie
PCT/EP1993/000114 WO1993015105A1 (en) 1992-02-01 1993-01-20 Process for recovering a high-purity virus-inactivated factor viii by anion exchanger chromatography

Publications (1)

Publication Number Publication Date
ATE203249T1 true ATE203249T1 (de) 2001-08-15

Family

ID=6451895

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902233T ATE203249T1 (de) 1992-02-01 1993-01-20 Verfahren zur gewinnung eines hochreinen factor viii/von willebrand faktor komplexes durch anionenaustauschchromatographie

Country Status (16)

Country Link
US (1) US5714590A (de)
EP (1) EP0625161B9 (de)
JP (1) JP3556947B2 (de)
KR (1) KR100240310B1 (de)
AT (1) ATE203249T1 (de)
AU (1) AU670776B2 (de)
DE (2) DE4204694C3 (de)
DK (1) DK0625161T4 (de)
ES (1) ES2157920T5 (de)
FI (1) FI109908B (de)
GR (1) GR3036849T3 (de)
NO (1) NO315426B1 (de)
PT (1) PT625161E (de)
RU (1) RU2096414C1 (de)
TW (1) TW362099B (de)
WO (1) WO1993015105A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2887329B2 (ja) * 1991-09-05 1999-04-26 バクスター インターナショナル インク 局所用フィブリノーゲン複合体
DE4342132C1 (de) * 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
FR2874216B1 (fr) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
PL2499165T3 (pl) * 2009-11-13 2017-04-28 Grifols Therapeutics Inc. Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
DE3878227D1 (de) * 1988-05-27 1993-03-18 Centre Regional De Transfusion Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie.
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
ES2053684T3 (es) * 1988-11-05 1994-08-01 Octapharma Ag Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia.
GB8913183D0 (en) * 1989-06-08 1989-07-26 Central Blood Lab Authority Chemical products
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.

Also Published As

Publication number Publication date
JP3556947B2 (ja) 2004-08-25
DE4204694A1 (de) 1993-08-12
DK0625161T4 (da) 2007-09-03
ES2157920T5 (es) 2007-12-16
DE69330458T2 (de) 2002-05-29
DE69330458T3 (de) 2008-01-17
FI943545A0 (fi) 1994-07-28
GR3036849T3 (en) 2002-01-31
EP0625161B2 (de) 2007-05-16
AU670776B2 (en) 1996-08-01
NO942832D0 (no) 1994-07-29
AU3351793A (en) 1993-09-01
ES2157920T3 (es) 2001-09-01
KR950700925A (ko) 1995-02-20
DE4204694C2 (de) 1994-02-10
DE4204694C3 (de) 1995-10-12
NO942832L (no) 1994-07-29
PT625161E (pt) 2001-10-31
EP0625161B9 (de) 2007-09-19
EP0625161A1 (de) 1994-11-23
WO1993015105A1 (en) 1993-08-05
DE69330458D1 (de) 2001-08-23
TW362099B (en) 1999-06-21
FI109908B (fi) 2002-10-31
KR100240310B1 (ko) 2000-01-15
DK0625161T3 (da) 2001-09-24
NO315426B1 (no) 2003-09-01
US5714590A (en) 1998-02-03
RU2096414C1 (ru) 1997-11-20
EP0625161B1 (de) 2001-07-18
JPH07503241A (ja) 1995-04-06
FI943545A (fi) 1994-07-28

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