ATE203248T1 - Proteinsynthese mittels nativer chemischer ligation (07.01.97) - Google Patents

Proteinsynthese mittels nativer chemischer ligation (07.01.97)

Info

Publication number
ATE203248T1
ATE203248T1 AT95919029T AT95919029T ATE203248T1 AT E203248 T1 ATE203248 T1 AT E203248T1 AT 95919029 T AT95919029 T AT 95919029T AT 95919029 T AT95919029 T AT 95919029T AT E203248 T1 ATE203248 T1 AT E203248T1
Authority
AT
Austria
Prior art keywords
ligation
native
full length
native chemical
chemical ligation
Prior art date
Application number
AT95919029T
Other languages
English (en)
Inventor
Stephen B H Kent
Tom W Muir
Philip E Dawson
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE203248T1 publication Critical patent/ATE203248T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
AT95919029T 1995-05-04 1995-05-04 Proteinsynthese mittels nativer chemischer ligation (07.01.97) ATE203248T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/005668 WO1996034878A1 (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation
CA002218620A CA2218620C (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation

Publications (1)

Publication Number Publication Date
ATE203248T1 true ATE203248T1 (de) 2001-08-15

Family

ID=25679740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95919029T ATE203248T1 (de) 1995-05-04 1995-05-04 Proteinsynthese mittels nativer chemischer ligation (07.01.97)

Country Status (13)

Country Link
EP (1) EP0832096B1 (de)
JP (1) JP3599346B2 (de)
AT (1) ATE203248T1 (de)
AU (1) AU711451B2 (de)
CA (1) CA2218620C (de)
DE (1) DE69521815T2 (de)
DK (1) DK0832096T3 (de)
ES (1) ES2161885T3 (de)
GR (1) GR3036895T3 (de)
MX (1) MX9708500A (de)
PT (1) PT832096E (de)
SI (1) SI0832096T1 (de)
WO (1) WO1996034878A1 (de)

Families Citing this family (65)

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US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
AU6020998A (en) 1997-01-08 1998-08-03 Life Technologies, Inc. Methods for production of proteins
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WO1998056807A1 (en) 1997-06-13 1998-12-17 Gryphon Sciences Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
US6168784B1 (en) 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
WO1999011655A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
US6875594B2 (en) * 1997-11-13 2005-04-05 The Rockefeller University Methods of ligating expressed proteins
JP2002527358A (ja) 1998-08-31 2002-08-27 グリフォン サイエンシーズ 脂質マトリックス介助化学連結方法および膜ポリペプチドの合成
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US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
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GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
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DE10335584B4 (de) * 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
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WO2007120614A2 (en) 2006-04-11 2007-10-25 Sloan-Kettering Institute For Cancer Research Homogeneous erythropoietin and other peptides and proteins, methods and intermediates for their preparation
EP2089426B1 (de) * 2006-06-20 2016-04-20 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Antimikrobielle kinocidinzusammensetzungen und anwendungsverfahren
CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3301108A1 (de) 2007-02-23 2018-04-04 Aileron Therapeutics, Inc. Makrocyclische systeme von triazol
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
EP2184290B1 (de) 2007-07-31 2015-02-18 Glytech, Inc. Verfahren zur peptidherstellung
WO2010011313A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
KR20110067097A (ko) 2008-08-19 2011-06-21 오츠카 가가쿠 가부시키가이샤 당단백질의 제조방법 및 스크리닝 방법
CN104961795A (zh) 2008-09-22 2015-10-07 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
EP2450364B1 (de) * 2009-06-26 2016-11-09 Glytech, Inc. Verfahren zur produktion eines peptidthioesters
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
WO2011007747A1 (ja) 2009-07-16 2011-01-20 大塚化学株式会社 糖鎖付加ａｉｌｉｍ細胞外ドメイン及びその製造方法
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
FR2971509B1 (fr) 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
RU2586524C2 (ru) 2011-03-10 2016-06-10 Глитек, Инк. Способ получения гликопептида, имеющего сиалированную сахарную цепь, и способ получения производного сиалилгликоаспарагина
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
IN2014CN02854A (de) 2011-09-26 2015-07-03 Glytech Inc
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JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
AU2013221433B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
FR2988392B1 (fr) 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native
HUE054444T2 (hu) 2012-09-26 2021-09-28 Harvard College Prolinnal lezárt kapcsos peptidek és felhasználásuk
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
JP6759109B2 (ja) 2014-05-21 2020-09-23 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｒａｓ抑制性ペプチドおよびその使用
CN112245565A (zh) 2014-09-24 2021-01-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
AU2018228182B2 (en) 2017-03-02 2024-04-11 Glytech, Inc. Production method for amino-acid polymer

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IT1228537B (it) * 1987-07-30 1991-06-20 Magis Farmaceutici Derivati della cisteina ad azione espettorante
EP0396116B1 (de) * 1989-05-02 1997-02-05 Abbott Laboratories Kovalente Kupplung von spezifischen Bindungspartnern an einer Festphase

Also Published As

Publication number Publication date
JP3599346B2 (ja) 2004-12-08
EP0832096B1 (de) 2001-07-18
DE69521815T2 (de) 2002-04-04
CA2218620C (en) 2007-02-27
WO1996034878A1 (en) 1996-11-07
ES2161885T3 (es) 2001-12-16
JPH11508874A (ja) 1999-08-03
SI0832096T1 (en) 2001-12-31
AU2474095A (en) 1996-11-21
PT832096E (pt) 2002-01-30
DK0832096T3 (da) 2001-10-01
GR3036895T3 (en) 2002-01-31
EP0832096A4 (de) 1998-08-05
AU711451B2 (en) 1999-10-14
DE69521815D1 (de) 2001-08-23
EP0832096A1 (de) 1998-04-01
CA2218620A1 (en) 1996-11-07
MX9708500A (es) 1998-02-28

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